Plasma N-glycome composition associates with chronic low back pain

• Published in: Biochimica et biophysica acta. General subjects Vol. 1862; no. 10; pp. 2124 - 2133
• Main Authors: Trbojević-Akmačić, Irena, Vučković, Frano, Vilaj, Marija, Skelin, Andrea, Karssen, Lennart C., Krištić, Jasminka, Jurić, Julija, Momčilović, Ana, Šimunović, Jelena, Mangino, Massimo, De Gregori, Manuela, Marchesini, Maurizio, Dagostino, Concetta, Štambuk, Jerko, Novokmet, Mislav, Rauck, Richard, Aulchenko, Yurii S., Primorac, Dragan, Kapural, Leonardo, Buyse, Klaas, Mesotten, Dieter, Williams, Frances M.K., van Zundert, Jan, Allegri, Massimo, Lauc, Gordan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2018
• Subjects: Belgium; Croatia; fluorescent labeling; gender; Glycan biomarker; glycomics; glycoproteins; glycosylation; inflammation; Italy; Low back pain; N-acetylglucosamine; pain; patients; Plasma N-glycosylation; polysaccharides; prognosis; psychosocial factors; Retrospective study; ultra-performance liquid chromatography; Belgium; Italy; Croatia; S3; CRO; S4; B; DMSO; HM; Low back pain; IgG; G0; Retrospective study; G1; 2-AB; G2; G3; G4; LDD; AbSur; ANCOVA; FDR; GlcNAc; LBP; ADCC; PBS; META; ACE; SDS; HILIC-SPE; MS; BEL; CLBP; Glycan biomarker; GPs; GU; Area; Plasma N-glycosylation; UPLC; LB; ITA; HILIC-UPLC; 2-PB; HB; FA; S0; S1; S2

Low back pain (LBP) is the symptom of a group of syndromes with heterogeneous underlying mechanisms and molecular pathologies, making treatment selection and patient prognosis very challenging. Moreover, symptoms and prognosis of LBP are influenced by age, gender, occupation, habits, and psychologic...