Preclinical evaluation of (S)-[18F]GE387, a novel 18-kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971 - Ramakrishnan, Nisha K.; Hird, Matthew; Thompson, Stephen; Williamson, David J.; Qiao, Luxi; Owen, David R.; Brooks, Allen F.; Scott, Peter J. H.; Bacallado, Sergio; O’Brien, John T.; Aigbirhio, Franklin I. (European journal of nuclear medicine and molecular imaging, 2021)
Keywords: Affinity; Animal models; Animals; Binding; Brain; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Carrier Proteins; Emission analysis; Enantiomers; Evaluation; Female; Fluorine isotopes; Gene polymorphism; Humans; Imaging; In vivo methods and tests; Inflammation; Lipopolysaccharides; Macaca mulatta - genetics; Male; Medicine; Medicine & Public Health; Neostriatum; Nuclear Medicine; Olfactory bulb; Oncology; Original; Original Article; Orthopedics; Polymorphism; Polymorphism, Genetic; Positron emission; Positron emission tomography; Proteins; Radioisotopes; Radiology; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, GABA - genetics; Receptors, GABA - metabolism; Receptors, GABA-A; Rodents; Tomography; TspO gene; Brain; Neuroinflammation; TSPO; GE387; Positron emission tomography; Polymorphism