Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 316; no. 3; pp. L487 - L497
• Main Authors: Zhang, Jie, Wang, Dan, Wang, Lei, Wang, Shaohua, Roden, Anja C., Zhao, Hao, Li, Xiujuan, Prakash, Y. S., Matteson, Eric L., Tschumperlin, Daniel J., Vassallo, Robert
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2019
• Subjects: Animal models; Arthritis; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - metabolism; Autoimmune diseases; Autoimmune Diseases - drug therapy; Biopsy; Cell proliferation; Extracellular matrix; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Human behavior; Humans; Idiopathic Pulmonary Fibrosis - drug therapy; Idiopathic Pulmonary Fibrosis - pathology; Inhibitors; Interleukin-17 - pharmacology; Interleukins; Janus kinase; Kinases; Lung - pathology; Lung diseases; Lung Diseases, Interstitial - drug therapy; Lung Diseases, Interstitial - pathology; NF-κB protein; Pathogenesis; Patients; Pharmacology; Proteins; Pulmonary fibrosis; Receptors, Interleukin-17 - drug effects; Receptors, Interleukin-17 - metabolism; Rheumatoid arthritis; Ribonucleic acid; RNA; RNA-mediated interference; siRNA; NF-κB; IL-17A; RA-ILD; IL-17RA; STAT3; human lung fibroblast; rheumatoid arthritis; IPF; JAK inhibitors

Interleukin (IL)-17 is a T helper 17 cytokine implicated in the pathogenesis of many autoimmune diseases, including rheumatoid arthritis (RA). Although IL-17A has a well-established role in murine pulmonary fibrosis models, its role in the tissue remodeling and fibrosis occurring in idiopathic pulmo...