Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease - Zhang, Jie; Wang, Dan; Wang, Lei; Wang, Shaohua; Roden, Anja C.; Zhao, Hao; Li, Xiujuan; Prakash, Y. S.; Matteson, Eric L.; Tschumperlin, Daniel J.; Vassallo, Robert (American journal of physiology. Lung cellular and molecular physiology, 2019)
Keywords: Animal models; Arthritis; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - metabolism; Autoimmune diseases; Autoimmune Diseases - drug therapy; Biopsy; Cell proliferation; Extracellular matrix; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Human behavior; Humans; Idiopathic Pulmonary Fibrosis - drug therapy; Idiopathic Pulmonary Fibrosis - pathology; Inhibitors; Interleukin-17 - pharmacology; Interleukins; Janus kinase; Kinases; Lung - pathology; Lung diseases; Lung Diseases, Interstitial - drug therapy; Lung Diseases, Interstitial - pathology; NF-κB protein; Pathogenesis; Patients; Pharmacology; Proteins; Pulmonary fibrosis; Receptors, Interleukin-17 - drug effects; Receptors, Interleukin-17 - metabolism; Rheumatoid arthritis; Ribonucleic acid; RNA; RNA-mediated interference; siRNA; NF-κB; IL-17A; RA-ILD; IL-17RA; STAT3; human lung fibroblast; rheumatoid arthritis; IPF; JAK inhibitors