Phase separation of RNA-binding protein promotes polymerase binding and transcription

An RNA-involved phase-separation model has been proposed for transcription control. However, the molecular links that connect RNA to the transcription machinery remain missing. Here we find that RNA-binding proteins (RBPs) constitute half of the chromatin proteome in embryonic stem cells (ESCs), som...

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Published inNature chemical biology Vol. 18; no. 1; pp. 70 - 80
Main Authors Shao, Wen, Bi, Xianju, Pan, Yixuan, Gao, Boyang, Wu, Jun, Yin, Yafei, Liu, Zhimin, Peng, Mengyuan, Zhang, Wenhao, Jiang, Xu, Ren, Wenlin, Xu, Yanhui, Wu, Zhongyang, Wang, Kaili, Zhan, Ge, Lu, J. Yuyang, Han, Xue, Li, Tong, Wang, Jianlong, Li, Guohong, Deng, Haiteng, Li, Bing, Shen, Xiaohua
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2022
Nature Publishing Group
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