Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure

• Published in: Cardiovascular diabetology Vol. 23; no. 1; pp. 223 - 17
• Main Authors: Kasperova, Barbora Judita, Mraz, Milos, Svoboda, Petr, Hlavacek, Daniel, Kratochvilova, Helena, Modos, Istvan, Vrzackova, Nikola, Ivak, Peter, Janovska, Petra, Kobets, Tatyana, Mahrik, Jakub, Riecan, Martin, Steiner Mrazova, Lenka, Stranecky, Viktor, Netuka, Ivan, Cajka, Tomas, Kuda, Ondrej, Melenovsky, Vojtech, Stemberkova Hubackova, Sona, Haluzik, Martin
• Format: Journal Article
• Language: English
• Published: England BioMed Central 28.06.2024; BMC
• Subjects: Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Architects; Biomarkers - blood; Body fat; Body mass index; Cardiovascular disease; Cardiovascular diseases; Congestive heart failure; Coronary vessels; Cytokines; Data analysis; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Ejection fraction; Epicardial Adipose Tissue; Ether lipids; Female; Ferroptosis; Flow cytometry; Gene expression; Glucose; Health risks; Heart diseases; Heart failure; Heart Failure - drug therapy; Heart Failure - metabolism; Heart Failure - physiopathology; Heart transplantation; Heart transplants; Humans; Inflammation; Inflammation Mediators - metabolism; Lipid metabolism; Lymphocytes; Male; Metabolomics; Middle Aged; Mortality; Obesity; Oleic acid; Oxidative stress; Patients; Pericardium - drug effects; Pericardium - metabolism; Severity of Illness Index; Sodium; Sodium-glucose cotransporter; Sodium-glucose cotransporter 2 inhibitors; Sodium-Glucose Transporter 2 Inhibitors - adverse effects; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use; Stroke Volume - drug effects; Treatment Outcome; Ventricular Function, Left - drug effects; United States > US; Germany; Heart failure; Ether lipids; Inflammation; Adipose tissue; Sodium-glucose cotransporter 2 inhibitors

Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are glucose-lowering agents used for the treatment of type 2 diabetes mellitus, which also improve heart failure and decrease the risk of cardiovascular complications. Epicardial adipose tissue (EAT) dysfunction was suggested to contribute to the d...