TPH and suicidal behavior: a study in suicide completers

• Published in: Molecular psychiatry Vol. 6; no. 1; pp. 98 - 102
• Main Authors: Turecki, G, Zhu, Z, Tzenova, J, Lesage, A, Séguin, M, Tousignant, M, Chawky, N, Vanier, C, Lipp, O, Alda, M, Joober, R, Benkelfat, C, Rouleau, G A
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.01.2001
• Subjects: Adult and adolescent clinical studies; Biological and medical sciences; Causes of; Genetic analysis; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetic variation; Haplotypes; Humans; Hydroxylases; Impulsive Behavior - genetics; Medical sciences; Nervous system; Neurosciences; Physiological aspects; Polymorphism, Genetic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Serotonin; Suicidal behavior; Suicide; Suicides & suicide attempts; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Canada; Human; Polymerase chain reaction; Allele; Completion; Gene; Exploration; Molecular biology; Locus; Suicide; Haplotype

An association between the gene that codes for tryptophan hydroxylase (TPH)-the rate-limiting enzyme in the synthesis of serotonin-and suicidal behavior has been investigated with some detail in samples of living subjects who attempted suicide. In this study, we investigated TPH and suicide completi...