Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

• Published in: Science translational medicine Vol. 9; no. 378
• Main Authors: Nakatsuji, Teruaki, Chen, Tiffany H, Narala, Saisindhu, Chun, Kimberly A, Two, Aimee M, Yun, Tong, Shafiq, Faiza, Kotol, Paul F, Bouslimani, Amina, Melnik, Alexey V, Latif, Haythem, Kim, Ji-Nu, Lockhart, Alexandre, Artis, Keli, David, Gloria, Taylor, Patricia, Streib, Joanne, Dorrestein, Pieter C, Grier, Alex, Gill, Steven R, Zengler, Karsten, Hata, Tissa R, Leung, Donald Y M, Gallo, Richard L
• Format: Journal Article
• Language: English
• Published: United States 22.02.2017
• Subjects: Amino Acid Sequence; Animals; Anti-Infective Agents - pharmacology; Anti-Infective Agents - therapeutic use; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - pharmacology; Bacteria - drug effects; Coagulase - metabolism; Colony Count, Microbial; Dermatitis, Atopic - drug therapy; Dermatitis, Atopic - microbiology; Dysbiosis - drug therapy; Dysbiosis - microbiology; Humans; Mice; Microbiota - drug effects; Skin - microbiology; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Sus scrofa

The microbiome can promote or disrupt human health by influencing both adaptive and innate immune functions. We tested whether bacteria that normally reside on human skin participate in host defense by killing , a pathogen commonly found in patients with atopic dermatitis (AD) and an important facto...