dual role for IQGAP1 in regulating exocytosis

• Published in: Journal of cell science Vol. 121; no. 3; pp. 391 - 403
• Main Authors: Rittmeyer, Eric N, Daniel, Samira, Hsu, Shu-Chan, Osman, Mahasin A
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.02.2008
• Subjects: Animals; Base Sequence; cdc42 GTP-Binding Protein - metabolism; Cell Line; Cell Polarity; Cytoskeletal Proteins - genetics; Cytoskeletal Proteins - metabolism; Exocytosis - physiology; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; HeLa Cells; Humans; Insulin-Secreting Cells - cytology; Insulin-Secreting Cells - physiology; Insulin-Secreting Cells - secretion; Mice; Models, Biological; Multiprotein Complexes; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; Protein Structure, Tertiary; ras GTPase-Activating Proteins - antagonists & inhibitors; ras GTPase-Activating Proteins - chemistry; ras GTPase-Activating Proteins - genetics; ras GTPase-Activating Proteins - physiology; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; RNA Interference; RNA, Small Interfering - genetics; Septins; Vesicular Transport Proteins - genetics; Vesicular Transport Proteins - metabolism

Polarized secretion is a tightly regulated event generated by conserved, asymmetrically localized multiprotein complexes, and the mechanism(s) underlying its temporal and spatial regulation are only beginning to emerge. Although yeast Iqg1p has been identified as a positional marker linking polarity...