Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

• Published in: Molecular neurodegeneration Vol. 19; no. 1; pp. 6 - 18
• Main Authors: Calvo-Rodriguez, Maria, Kharitonova, Elizabeth K., Snyder, Austin C., Hou, Steven S., Sanchez-Mico, Maria Virtudes, Das, Sudeshna, Fan, Zhanyun, Shirani, Hamid, Nilsson, K. Peter R., Serrano-Pozo, Alberto, Bacskai, Brian J.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 18.01.2024; BMC
• Subjects: Age; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal models; Animals; Antibodies; Antioxidants; Antioxidants - metabolism; Antioxidants - pharmacology; Axon guidance; Calcium influx; Disease Models, Animal; Embryos; Laboratories; Mice; Mitochondria; Mitochondria - metabolism; Mutation; Neurodegeneration; Neurodegenerative diseases; Neuroimaging; Neurons; Neuropathology; Neuroprotection; Neurotoxicity; Oxidation-Reduction; Oxidative stress; Oxidative Stress - physiology; Pathophysiology; Penicillin; Plasmids; Proteins; Reactive oxygen species; ROS; Senile plaques; SS31; Tau protein; Toxicity; β-Amyloid; Oxidative stress; Mitochondria; Alzheimer’s disease; Neurodegeneration; ROS; SS31; Multiphoton microscopy

Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer's disease (AD). Damaged mitochondria are one of the main sources of reactive oxygen species and accumulate in Aβ plaque-associated dystrophic neurites in the AD br...