Expression of glioma-associated oncogene homolog 1 is associated with invasion and postoperative liver metastasis in colon cancer

• Published in: International journal of medical sciences Vol. 9; no. 5; pp. 334 - 338
• Main Authors: Ding, Yin-lu, Zhou, Yong, Xiang, Lei, Ji, Zhi-peng, Luo, Zhou-hong
• Format: Journal Article
• Language: English
• Published: Australia Ivyspring International Publisher 01.01.2012
• Subjects: Colonic Neoplasms - complications; Colonic Neoplasms - metabolism; Female; Humans; Immunohistochemistry; In Vitro Techniques; Liver Neoplasms - metabolism; Liver Neoplasms - secondary; Lymphatic Metastasis; Male; Middle Aged; Proportional Hazards Models; Research Paper; Tissue Array Analysis; Transcription Factors - metabolism; Zinc Finger Protein GLI1; Colon neoplasm; Glioma-associated oncogene 1; Liver metastasis
• ISSN: 1449-1907; 1449-1907
• DOI: 10.7150/ijms.4553

To investigate the expression of glioma-associated oncogene homolog 1(Gli-1) in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis. Expression of Gli-1 was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between Gli-1 expression and clinicopathological parameters, postoperative liver metastasis were analyzed. Gli-1 protein expression was significantly increased in colon cancer tissues compared to normal colon tissues (P=0.037). Gli-1 expression in colon tissues was increased in patients with lymph node metastases (P=0.022) and higher T stages (P=0.030). Postoperative live metastasis-free survival period was significantly longer in low Gli-1 expression group than that of high Gli-1 expression group (48.22±10.03 months vs 20.46±6.32 months, P=0.001). Multivariate analysis showed that Gli-1 expression level is an independent prognostic factor for postoperative live metastasis-free survival. Colon cancer is associated with an upregulation of Gli-1 protein expression in colon tissues. In patients with colon cancer, Gli-1 expression level is closely related to lymph node metastases, T stages and postoperative live metastasis-free survival periods, indicative of a possible role of Gli-1 expression in colon cancer progression.