Galactose in human metabolism, glycosylation and congenital metabolic diseases: Time for a closer look

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 8; p. 129898
• Main Authors: Conte, Federica, van Buuringen, Nicole, Voermans, Nicol C., Lefeber, Dirk J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2021
• Subjects: cell adhesion; Collagen glycosylation; Congenital disorders of glycosylation; energy; Galactose; Galactosemia; glycolipids; glycosylation; homeostasis; humans; Keratan sulfate; Lysosomal disorders; proteoglycans; Lysosomal disorders; Congenital disorders of glycosylation; Galactose; Collagen glycosylation; Keratan sulfate; Galactosemia

Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy production and storage in several human tissues while also being a precursor for glycosylation. Galactosylated glycoconjugates, such as glycoproteins, keratan sulfate-containing proteoglycans and glycolipids,...