Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway - Tang, Yang-Shuo; Zhao, Yan-Hua; Zhong, Yong; Li, Xiao-Zhao; Pu, Jia-Xi; Luo, Yan-Cheng; Zhou, Qiao-Ling (Inflammation research, 2019)
Keywords: Adenosine Triphosphate - pharmacology; Allergology; Antioxidants; Benzylisoquinolines - pharmacology; Biomedical and Life Sciences; Biomedicine; Caspase; Caspase 1 - metabolism; Caspase-1; Cell proliferation; Cell Survival; Cell viability; Dermatology; Disease Progression; Embryos; Endothelial cells; Endothelial Cells - drug effects; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells - drug effects; Humans; IL-1β; Immunology; Inflammasomes; Inflammation; Interleukin 18; Kidney diseases; Kinases; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Malondialdehyde - metabolism; Neurology; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Original Research Paper; Overexpression; Oxidation; Oxidative Stress; Pharmacology/Toxicology; Polymerase chain reaction; Pyroptosis; Reactive Oxygen Species - metabolism; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - metabolism; Rheumatology; RNA, Small Interfering - metabolism; Signal Transduction; Signaling; siRNA; Superoxide Dismutase - metabolism; Neferine; ROS/NLRP3/Caspase-1 signaling pathway; Cell pyroptosis; NLRP3 inflammasome; Chronic kidney disease (CKD)