Rho Rocks PTEN

Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the...

Full description

Saved in:
Bibliographic Details
Published inNature cell biology Vol. 7; no. 4; pp. 334 - 335
Main Authors Meili, Ruedi, Sasaki, Atsuo T, Firtel, Richard A
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.04.2005
Subjects
Animals
cdc42 GTP-Binding Protein - metabolism
Chemotaxis
Chemotaxis - physiology
Dictyostelium
Dictyostelium - enzymology
Humans
Intracellular Signaling Peptides and Proteins
Leukocytes - metabolism
Mice
Models, Biological
Neutrophils - metabolism
Phosphatidylinositol
Phosphoric Monoester Hydrolases - metabolism
Phosphorylation
Physiological aspects
Protein-Serine-Threonine Kinases - metabolism
PTEN Phosphohydrolase
rho-Associated Kinases
rhoA GTP-Binding Protein - metabolism
Tumor Suppressor Proteins - metabolism
United States
Online AccessGet full text

Cover

More Information
Summary:Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the rear of chemotaxing neutrophils is mediated by the small GTPase RhoA.
Bibliography:SourceType-Other Sources-1
ObjectType-News-1
ObjectType-Commentary-2
content type line 66
ISSN:1465-7392
1476-4679
DOI:10.1038/ncb0405-334