HIV-1 Tat Interactions with p300 and PCAF Transcriptional Coactivators Inhibit Histone Acetylation and Neurotrophin Signaling through CREB

• Published in: The Journal of biological chemistry Vol. 280; no. 10; pp. 9390 - 9399
• Main Authors: Wong, Kasuen, Sharma, Anima, Awasthi, Soumya, Matlock, Elizabeth F., Rogers, Lowery, Van Lint, Carine, Skiest, Daniel J., Burns, Dennis K., Harrod, Robert
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.03.2005; American Society for Biochemistry and Molecular Biology
• Subjects: Acetylation; Acetyltransferases - metabolism; Amino Acid Sequence; Animals; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein - physiology; Fluorescence Resonance Energy Transfer; Gene Products, tat - metabolism; Histone Acetyltransferases; Histones - metabolism; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; Microscopy, Confocal; Molecular Sequence Data; Nerve Growth Factors - physiology; Neuroblastoma; p300-CBP Transcription Factors; PC12 Cells; Pheochromocytoma; Rats; Recombinant Fusion Proteins - isolation & purification; Recombinant Fusion Proteins - metabolism; Signal Transduction; tat Gene Products, Human Immunodeficiency Virus; Transcription Factors - metabolism; Transfection; Virus Replication

The human immunodeficiency virus type-1 (HIV-1) infects microglia, macrophages, and astrocytes in the central nervous system (CNS) and may cause severe neurological diseases, such as AIDS-related dementias or progressive encephalopathies, as a result of CNS inflammation and neurotrophin signaling de...