Distinct “Immunoallertypes” of Disease and High Frequencies of Sensitization in Non–Cystic Fibrosis Bronchiectasis

• Published in: American journal of respiratory and critical care medicine Vol. 199; no. 7; pp. 842 - 853
• Main Authors: Mac Aogáin, Micheál, Tiew, Pei Yee, Lim, Albert Yick Hou, Low, Teck Boon, Tan, Gan Liang, Hassan, Tidi, Ong, Thun How, Pang, Sze Lei, Lee, Zi Yang, Gwee, Xiao Wei, Martinus, Christopher, Sio, Yang Yie, Matta, Sri Anusha, Ong, Tan Ching, Tiong, Yuen Seng, Wong, Kang Ning, Narayanan, Sriram, Au, Veonice Bijin, Marlier, Damien, Keir, Holly R., Tee, Augustine, Abisheganaden, John Arputhan, Koh, Mariko Siyue, Wang, De Yun, Connolly, John E., Chew, Fook Tim, Chalmers, James D., Chotirmall, Sanjay H.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.04.2019
• Subjects: Adult; Aged; Aged, 80 and over; Allergens - adverse effects; Allergens - immunology; Allergies; Animals; Aspergillus; Asthma; Asthma - etiology; Asthma - immunology; Bronchiectasis - complications; Bronchiectasis - immunology; Cell adhesion & migration; Chronic obstructive pulmonary disease; Clinical outcomes; Cohort Studies; Cystic fibrosis; Cytokines; Female; Hospitals; Humans; Hypersensitivity - immunology; Immunization; Infections; Male; Middle Aged; Neutrophils; Outpatient care facilities; Patients; Pyroglyphidae; Kuala Lumpur Malaysia; Malaysia; Singapore; United Kingdom > UK; allergy; sensitization; house dust mite; bronchiectasis

Allergic sensitization is associated with poor clinical outcomes in asthma, chronic obstructive pulmonary disease, and cystic fibrosis; however, its presence, frequency, and clinical significance in non-cystic fibrosis bronchiectasis remain unclear. To determine the frequency and geographic variabil...