Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS MND: Report on the 142nd ENMC international workshop

• Published in: Amyotrophic lateral sclerosis Vol. 8; no. 4; pp. 217 - 223
• Main Authors: Ludolph, Albert C., Bendotti, Caterina, Blaugrund, Eran, Hengerer, Bastian, Löffler, Jean-Philippe, Martin, Joanne, Meininger, Vincent, Meyer, Thomas, Moussaoui, Saliha, Robberecht, Wim, Scott, Sean, Silani, Vincenzo, Van Den Berg, Leonard H., ENMC GROUP FOR THE ESTABLISHMENT OF GUIDELINES FOR THE CONDUCT OF PRECLINICAL AND PROOF OF CONCEPT STUDIES IN ALS MND MODELS
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 2007; Taylor & Francis
• Subjects: Amyotrophic Lateral Sclerosis - drug therapy; Animals; Disease Models, Animal; Drug Evaluation, Preclinical - methods; Humans; Mice; Mice, Transgenic; Superoxide Dismutase - genetics

A transgenic animal model for anterior horn cell loss was established in 1994. This model is based on the insertion of a high copy number of disease-causing human Cu Zn SOD mutations into the intact mouse genome. It serves to establish hypotheses for the pathogenesis of anterior horn cell death, but...