Unfolding the Role of BDNF as a Biomarker for Treatment of Depression

Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals’ quality of life. The exact pa...

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Published inJournal of molecular neuroscience Vol. 71; no. 10; pp. 2008 - 2021
Main Authors Rana, Tarapati, Behl, Tapan, Sehgal, Aayush, Srivastava, Pranay, Bungau, Simona
Format Journal Article
LanguageEnglish
Published New York Springer US 01.10.2021
Springer Nature B.V
Subjects
Abnormalities
Animals
Antidepressants
Antidepressive Agents - therapeutic use
Biomarkers
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Brain
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cell Biology
Depression - drug therapy
Depression - metabolism
Humans
Mental depression
Mental disorders
Neurochemistry
Neurogenesis
Neurology
Neuroplasticity
Neurosciences
Neurotransmission
Pathogenesis
Pathophysiology
Proteomics
Quality of life
Synaptic plasticity
Neuroplasticity
Antidepressant
Depression
Brain-derived neurotrophic factor
Mental illness
Neurogenesis
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Abstract Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals’ quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal growth and proliferation, synaptic neurotransmission, and neuroplasticity. The neurotrophic theory of depression proposes that depression results from reduced BDNF levels in the brain, which can be treated with antidepressants to alleviate depressive behavior and increase BDNF levels. The aim of this review is to provide broad insight into the role of BDNF in the pathogenesis of depression and in antidepressant therapy. The studies mentioned in this review article greatly support the role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants. Since abnormalities in BDNF levels lead to the production of diverse insults that amplify the development or progression of depression, it is important to study and explore BDNF impairment in relation to depression, neuroplasticity, and neurogenesis, and increasing BDNF levels through antidepressant therapy, showing positive response in the management of depression.
AbstractList Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals' quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal growth and proliferation, synaptic neurotransmission, and neuroplasticity. The neurotrophic theory of depression proposes that depression results from reduced BDNF levels in the brain, which can be treated with antidepressants to alleviate depressive behavior and increase BDNF levels. The aim of this review is to provide broad insight into the role of BDNF in the pathogenesis of depression and in antidepressant therapy. The studies mentioned in this review article greatly support the role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants. Since abnormalities in BDNF levels lead to the production of diverse insults that amplify the development or progression of depression, it is important to study and explore BDNF impairment in relation to depression, neuroplasticity, and neurogenesis, and increasing BDNF levels through antidepressant therapy, showing positive response in the management of depression.Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals' quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal growth and proliferation, synaptic neurotransmission, and neuroplasticity. The neurotrophic theory of depression proposes that depression results from reduced BDNF levels in the brain, which can be treated with antidepressants to alleviate depressive behavior and increase BDNF levels. The aim of this review is to provide broad insight into the role of BDNF in the pathogenesis of depression and in antidepressant therapy. The studies mentioned in this review article greatly support the role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants. Since abnormalities in BDNF levels lead to the production of diverse insults that amplify the development or progression of depression, it is important to study and explore BDNF impairment in relation to depression, neuroplasticity, and neurogenesis, and increasing BDNF levels through antidepressant therapy, showing positive response in the management of depression.
Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals' quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal growth and proliferation, synaptic neurotransmission, and neuroplasticity. The neurotrophic theory of depression proposes that depression results from reduced BDNF levels in the brain, which can be treated with antidepressants to alleviate depressive behavior and increase BDNF levels. The aim of this review is to provide broad insight into the role of BDNF in the pathogenesis of depression and in antidepressant therapy. The studies mentioned in this review article greatly support the role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants. Since abnormalities in BDNF levels lead to the production of diverse insults that amplify the development or progression of depression, it is important to study and explore BDNF impairment in relation to depression, neuroplasticity, and neurogenesis, and increasing BDNF levels through antidepressant therapy, showing positive response in the management of depression.
Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression are usually recurrent in vulnerable individuals, and persistence of symptoms significantly impairs individuals’ quality of life. The exact pathophysiology of depression remains ambiguous, though many hypotheses have been proposed. Brain-derived neurotrophic factor (BDNF) has recently been reported to play a vital role in the pathophysiology of depression. BDNF is an important neurotrophic factor found in the human brain and is involved in neuronal growth and proliferation, synaptic neurotransmission, and neuroplasticity. The neurotrophic theory of depression proposes that depression results from reduced BDNF levels in the brain, which can be treated with antidepressants to alleviate depressive behavior and increase BDNF levels. The aim of this review is to provide broad insight into the role of BDNF in the pathogenesis of depression and in antidepressant therapy. The studies mentioned in this review article greatly support the role of BDNF in the pathogenesis of depression and treatment of this disorder with antidepressants. Since abnormalities in BDNF levels lead to the production of diverse insults that amplify the development or progression of depression, it is important to study and explore BDNF impairment in relation to depression, neuroplasticity, and neurogenesis, and increasing BDNF levels through antidepressant therapy, showing positive response in the management of depression.
Author Sehgal, Aayush
Behl, Tapan
Bungau, Simona
Rana, Tarapati
Srivastava, Pranay
Author_xml – sequence: 1
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  surname: Rana
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  surname: Behl
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  surname: Sehgal
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  givenname: Simona
  surname: Bungau
  fullname: Bungau, Simona
  organization: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea
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Copyright Springer Science+Business Media, LLC, part of Springer Nature 2020
2020. Springer Science+Business Media, LLC, part of Springer Nature.
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ID FETCH-LOGICAL-c441t-d2847bfaade808c067c24dab82b99fc48463e1faab4f211933e64c1bc008b31e3
IEDL.DBID U2A
ISSN 0895-8696
1559-1166
IngestDate Fri Jul 11 15:32:52 EDT 2025
Fri Jul 25 22:40:46 EDT 2025
Wed Feb 19 02:28:08 EST 2025
Tue Jul 01 03:06:29 EDT 2025
Thu Apr 24 22:56:50 EDT 2025
Fri Feb 21 02:47:10 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 10
Keywords Neuroplasticity
Antidepressant
Depression
Brain-derived neurotrophic factor
Mental illness
Neurogenesis
Language English
License 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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MergedId FETCHMERGED-LOGICAL-c441t-d2847bfaade808c067c24dab82b99fc48463e1faab4f211933e64c1bc008b31e3
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PMID 33230708
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crossref_primary_10_1007_s12031_020_01754_x
crossref_citationtrail_10_1007_s12031_020_01754_x
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PublicationDate 2021-10-01
PublicationDateYYYYMMDD 2021-10-01
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  year: 2021
  text: 2021-10-01
  day: 01
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PublicationPlace New York
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PublicationTitle Journal of molecular neuroscience
PublicationTitleAbbrev J Mol Neurosci
PublicationTitleAlternate J Mol Neurosci
PublicationYear 2021
Publisher Springer US
Springer Nature B.V
Publisher_xml – name: Springer US
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Snippet Depression is a well-known disabling mental illness characterized by sadness, loss of interest in activities, and decreased energy. The symptoms of depression...
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SubjectTerms Abnormalities
Animals
Antidepressants
Antidepressive Agents - therapeutic use
Biomarkers
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Brain
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Cell Biology
Depression - drug therapy
Depression - metabolism
Humans
Mental depression
Mental disorders
Neurochemistry
Neurogenesis
Neurology
Neuroplasticity
Neurosciences
Neurotransmission
Pathogenesis
Pathophysiology
Proteomics
Quality of life
Synaptic plasticity
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Title Unfolding the Role of BDNF as a Biomarker for Treatment of Depression
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