Functional alterations and transcriptomic changes during zebrafish cardiac aging
Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafi...
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| Published in | Biogerontology (Dordrecht) Vol. 21; no. 5; pp. 637 - 652 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.10.2020
Springer Nature B.V |
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| Abstract | Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets. |
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| AbstractList | Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets. Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets. Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets.Aging dramatically increases the risk of cardiovascular diseases in human. Animal models are of great value to study cardiac aging, and zebrafish have become a popular model for aging study recently. However, there is limited knowledge about the progression and regulation of cardiac aging in zebrafish. In this study we first validated the effectiveness of a panel of aging-related markers and revealed their spatial-temporal specificity. Using these markers, we discovered that cardiac aging in zebrafish initiated at mid-age around 24 months, followed by a gradual progression marked with increased DNA damage, inflammatory response and reduced mitochondrial function. Furthermore, we showed aging-related expression profile change in zebrafish hearts was similar to that in rat hearts. Overall, our results provide a deeper insight into the cardiac aging process in zebrafish, which will set up foundation for generating novel cardiac aging models suitable for large scale screening of pharmaceutical targets. |
| Author | Ma, Jinmin Li, Xueyu Lu, Chenqi Zhang, Ruilin Shao, Xuelian Fu, Yu |
| Author_xml | – sequence: 1 givenname: Xuelian surname: Shao fullname: Shao, Xuelian organization: Department of Genetics and Genetic Engineering, School of Life Sciences, Fudan University – sequence: 2 givenname: Yu surname: Fu fullname: Fu, Yu organization: Department of Genetics and Genetic Engineering, School of Life Sciences, Fudan University – sequence: 3 givenname: Jinmin surname: Ma fullname: Ma, Jinmin organization: Department of Genetics and Genetic Engineering, School of Life Sciences, Fudan University – sequence: 4 givenname: Xueyu surname: Li fullname: Li, Xueyu organization: Department of Genetics and Genetic Engineering, School of Life Sciences, Fudan University – sequence: 5 givenname: Chenqi surname: Lu fullname: Lu, Chenqi email: luchenqi@fudan.edu.cn organization: Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University – sequence: 6 givenname: Ruilin orcidid: 0000-0002-6594-450X surname: Zhang fullname: Zhang, Ruilin email: zhangruilin@whu.edu.cn organization: School of Basic Medical Sciences, Wuhan University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32372324$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Aging Animal models Biomedical and Life Sciences Cardiovascular diseases Cell Biology Danio rerio Developmental Biology DNA damage Geriatrics/Gerontology Inflammation Life Sciences Mitochondria Research Article |
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| Title | Functional alterations and transcriptomic changes during zebrafish cardiac aging |
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