Insights into the Substrate Specificity, Inhibitors, Regulation, and Polymorphisms and the Clinical Impact of Human Cytochrome P450 1A2

• Published in: The AAPS journal Vol. 11; no. 3; pp. 481 - 494
• Main Authors: Zhou, Shu-Feng, Yang, Li-Ping, Zhou, Zhi-Wei, Liu, Ya-He, Chan, Eli
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.09.2009
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors - pharmacology; Gene Expression Regulation, Enzymologic; Humans; Mice; Mice, Knockout; Models, Molecular; Pharmacology/Toxicology; Pharmacy; Polymorphism, Single Nucleotide; Review; Review Article; Signal Transduction; Substrate Specificity; inducer; single nuclear polymorphism; inhibitor; substrate; CYP1A2

Human CYP1A2 is one of the major CYPs in human liver and metabolizes a variety of clinically important drugs (e.g., clozapine, tacrine, tizanidine, and theophylline), a number of procarcinogens (e.g. benzo[ a ]pyrene and aflatoxin B 1 ), and several important endogenous compounds (e.g. steroids and...