Smilax China L. Rhizome Extract Inhibits Nuclear Factor-κ B and Induces Apoptosis in Ovarian Cancer Cells

• Published in: Chinese journal of integrative medicine Vol. 21; no. 12; pp. 907 - 915
• Main Author: 胡丽玲 陈东生 王燕燕 秦铀 黄璞 于丽秀 廖婧 华小黎
• Format: Journal Article
• Language: English
• Published: Beijing Chinese Association of Traditional and Western Medicine 01.12.2015
• Subjects: Apoptosis - drug effects; caspase-3; Cell Line, Tumor; Cell Survival - drug effects; Female; Humans; Medicine; Medicine & Public Health; NF-kappa B - antagonists & inhibitors; Original Article; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Plant Extracts - pharmacology; Smilax; 卵巢癌细胞; 提取物; 核因子-κB; 根茎; 细胞凋亡; 菝葜; 诱导; nuclear factor-κB; G; A2780 cells; apoptosis; M arrest; L. rhizome; chemosensitivity; G2/M arrest; Smilax china L. rhizome

Objective： To study the antitumor effects and associated mechanisms of extract of the Smilax china L. rhizome （SCR） on ovarian cancer cells. Methods： Ovarian cancer cells A2780 were treated with different concentrations of SCR extract （SCRE）, and compared with controls. Effects on cell growth were e...