Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway - Wang, Ning; Nie, Huan; Zhang, Yueyue; Han, Huiying; Wang, Shan; Liu, Wenjuan; Tian, Kuo (Inflammation research, 2022)
Keywords: Adaptor Proteins, Signal Transducing - metabolism; Allergology; Animals; Apoptosis Regulatory Proteins; Biomedical and Life Sciences; Biomedicine; Brain injury; Brain Ischemia - drug therapy; Brain Ischemia - prevention & control; Cerebral blood flow; Cerebral infarction; Deprivation; Dermatology; Dexmedetomidine - pharmacology; Dexmedetomidine - therapeutic use; Heme Oxygenase-1; Immunology; Inflammasomes; Inflammation; Inhibitors; Injuries; Ischemia; Membrane Proteins; Mice; Microglia; Microglia - metabolism; Moisture content; Neurology; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NF-E2-Related Factor 2 - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Nuclear transport; Occlusion; Original Resarch Article; Oxidative stress; Pharmacology/Toxicology; Polarization; Reperfusion; Reperfusion Injury - metabolism; Rheumatology; Signal Transduction; Water content; Oxidative stress; Nrf2; Cerebral ischemic injury; Microglia polarization; Dexmedetomidine; Inflammatory injury; NLRP3; HO-1