Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain

Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors’ quality of life and prevents them from restoring their pre-cancer life. This review is intended to address th...

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Published inCancer chemotherapy and pharmacology Vol. 84; no. 1; pp. 1 - 14
Main Authors El-Agamy, Sara Emad, Abdel-Aziz, Amal Kamal, Esmat, Ahmed, Azab, Samar S.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2019
Springer Nature B.V
Subjects
Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - adverse effects
Brain - physiopathology
Cancer
Cancer Research
Chemotherapy
Cognition - drug effects
Cognition Disorders - chemically induced
Cognition Disorders - physiopathology
Cognitive ability
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Drug therapy
Humans
Medicine
Medicine & Public Health
Neoplasms - drug therapy
Neurotoxicity
Oncology
Pharmacology/Toxicology
Quality of Life
Review Article
Chemobrain
Neuropsychological tests
Doxorubicin
Memory
Hippocampus
Online AccessGet full text
ISSN0344-5704
1432-0843
1432-0843
DOI10.1007/s00280-019-03827-0

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Abstract Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors’ quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ‘’doxorubicin’’, which has been shown to be implicated in strenuous central neurotoxicity despite being—almost entirely—peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.
AbstractList Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors' quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ''doxorubicin'', which has been shown to be implicated in strenuous central neurotoxicity despite being-almost entirely-peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors' quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ''doxorubicin'', which has been shown to be implicated in strenuous central neurotoxicity despite being-almost entirely-peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.
Chemobrain refers to a common sequela experienced by a substantial subset of cancer patients exposed to chemotherapeutic treatment, a phenomenon that dramatically deteriorates the survivors' quality of life and prevents them from restoring their pre-cancer life. This review is intended to address the current knowledge regarding the mechanisms underlying the pathophysiology of the chemobrain phenomenon, with special focus on the antineoplastic agent ''doxorubicin'', which has been shown to be implicated in strenuous central neurotoxicity despite being-almost entirely-peripherally confined. Moreover, the assessment of the post-chemotherapy cognitive impairment in both human and animal subjects, and the potential pharmacotherapy and behavioral intervention strategies are reviewed.
Author Abdel-Aziz, Amal Kamal
Esmat, Ahmed
Azab, Samar S.
El-Agamy, Sara Emad
Author_xml – sequence: 1
  givenname: Sara Emad
  surname: El-Agamy
  fullname: El-Agamy, Sara Emad
  organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University
– sequence: 2
  givenname: Amal Kamal
  surname: Abdel-Aziz
  fullname: Abdel-Aziz, Amal Kamal
  organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University
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  givenname: Ahmed
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  fullname: Esmat, Ahmed
  organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University
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  givenname: Samar S.
  orcidid: 0000-0002-0253-8280
  surname: Azab
  fullname: Azab, Samar S.
  email: samar_saad_azab@pharma.asu.edu.eg
  organization: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30955080$$D View this record in MEDLINE/PubMed
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Cites_doi 10.2147/DDDT.S103511
10.1007/BF00685379
10.1002/pon.742
10.1097/00012272-199503000-00003
10.1016/j.soncn.2013.08.005
10.1159/000442726
10.1111/jgs.12607
10.1158/0008-5472.CAN-10-1854
10.3816/CBC.2008.n.006
10.1523/JNEUROSCI.0538-14.2014
10.1016/j.bbr.2015.06.028
10.1016/j.freeradbiomed.2008.08.008
10.18632/aging.101144
10.1200/JCO.2001.19.6.1802
10.1016/j.neuroscience.2003.11.040
10.1152/physrev.00049.2005
10.1176/ajp.137.5.597
10.1002/hbm.21033
10.1002/pon.1133
10.1007/s12035-017-0797-7
10.1139/apnm-2013-0380
10.1007/s11064-016-1949-2
10.1002/cncr.25685
10.1016/j.bbr.2016.04.017
10.1016/j.neuroscience.2010.11.007
10.2174/092986709788803312
10.2478/s13380-012-0027-8
10.1038/nrclinonc.2015.152
10.1016/j.jconrel.2016.01.046
10.1016/j.cyto.2013.11.003
10.1111/j.1471-4159.2006.04179.x
10.1016/j.bbi.2012.09.003
10.1007/s11764-015-0463-x
10.1007/s00213-013-3394-0
10.1007/s11682-013-9243-2
10.1038/npp.2016.134
10.1007/s11920-004-0023-y
10.1007/s11011-008-9100-y
10.1007/s10549-012-2385-x
10.1111/j.1527-3458.2008.00040.x
10.1016/j.cnr.2006.09.004
10.1016/j.freeradbiomed.2011.03.009
10.1182/blood.V97.8.2381
10.1016/j.mpmed.2007.10.012
10.1016/j.ejcsup.2013.07.007
10.1007/978-1-4419-6306-2_19
10.1016/0166-2236(93)90016-F
10.3390/ijms14047542
10.1007/s10549-005-7093-3
10.1093/jnci/dju186
10.1016/j.bbr.2009.11.017
10.1188/09.onf.e1-e10
10.1081/CNV-100103136
10.1089/jpm.2008.0230
10.3109/09638288.2015.1038364
10.1038/s41598-017-04634-4
10.1016/j.clbc.2013.02.004
10.1016/j.cyto.2014.12.006
10.1007/s00210-016-1338-z
10.3109/10428194.2014.915546
10.1523/JNEUROSCI.2723-06.2006
10.1007/s11764-009-0098-x
10.1016/j.nurt.2010.07.006
10.1016/j.jpainsymman.2013.02.014
10.1177/0269216309106872
10.1200/JCO.2000.18.14.2695
10.1188/07.onf.981-994
10.1002/acn3.121
10.1371/journal.pone.0030010
10.1158/1078-0432.CCR-11-2000
10.1016/j.mcn.2017.11.014
10.1002/cncr.20272
10.1016/j.neuroscience.2010.01.021
10.1155/2016/6945415
10.1016/j.bbr.2015.06.007
10.3816/CBC.2002.s.018
10.1200/jco.2000.18.6.1301
10.1016/j.pbb.2009.09.001
10.3109/10715762.2012.678841
10.1023/A:1013337209957
10.18632/oncotarget.19835
10.1111/j.1460-9568.2008.06325.x
10.1615/JEnvironPatholToxicolOncol.2017017087
10.1124/pr.56.2.6
10.1097/00012272-199703000-00003
10.1371/journal.pone.0124988
10.1016/j.ctrv.2014.03.003
10.1016/j.nlm.2003.07.003
10.1371/journal.pone.0108002
10.1016/j.ncl.2007.04.001
10.1080/10715760500143478
10.1254/jphs.09292SC
10.1007/s10549-007-9686-5
10.1016/j.freeradbiomed.2014.06.006
10.1002/cncr.24287
10.1016/j.neuropharm.2011.07.013
10.1002/jnr.21158
10.1038/nrn2822
10.1016/j.clbc.2013.10.010
10.1002/pon.1878
10.1007/s00520-007-0341-9
10.1089/ars.2007.1957
10.1523/JNEUROSCI.2721-09.2010
10.1016/j.bbi.2011.07.225
10.1016/S1470-2045(10)70294-1
10.1038/clpt.2011.112
10.1093/jnci/90.3.210
10.1200/jco.2015.33.15_suppl.9504
10.1016/j.nbd.2006.02.013
10.1523/JNEUROSCI.23-19-07317.2003
10.1007/s00467-004-1538-5
10.1007/s11682-017-9674-2
10.1200/jco.2012.43.0116
10.1016/j.neuro.2009.04.009
10.14694/EdBook_AM.2015.35.e553
10.18632/oncotarget.25718
10.1016/0165-0270(84)90007-4
10.1037/0033-295X.99.2.195
ContentType Journal Article
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Cancer Chemotherapy and Pharmacology is a copyright of Springer, (2019). All Rights Reserved.
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Thu Apr 24 23:10:21 EDT 2025
Fri Feb 21 02:33:15 EST 2025
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Issue 1
Keywords Chemobrain
Neuropsychological tests
Doxorubicin
Memory
Hippocampus
Language English
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PublicationDate 2019-07-01
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PublicationTitle Cancer chemotherapy and pharmacology
PublicationTitleAbbrev Cancer Chemother Pharmacol
PublicationTitleAlternate Cancer Chemother Pharmacol
PublicationYear 2019
Publisher Springer Berlin Heidelberg
Springer Nature B.V
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References Minotti, Menna, Salvatorelli, Cairo, Gianni (CR13) 2004; 56
Pomykala, Ganz, Bower, Kwan, Castellon, Mallam, Cheng, Ahn, Breen, Irwin, Silverman (CR92) 2013; 7
Kohli, Fisher, Tra, Adams, Mapstone, Wesnes, Roscoe, Morrow (CR108) 2009; 115
Hurria, Patel, Mortimer, Luu, Somlo, Katheria, Ramani, Hansen, Feng, Chuang, Geist, Silverman (CR91) 2014; 14
Daiber, Daub, Bachschmid, Schildknecht, Oelze, Steven, Schmidt, Megner, Wada, Tanabe, Munzel, Bottari, Ullrich (CR24) 2013; 14
Lenz, Pugh, Milligan, Gift, Suppe (CR80) 1997; 19
Barry, Byun, Tantawy, Mackey, Wilson, Stark, Flom, Gee, Quarles (CR95) 2018; 12
Lenz, Suppe, Gift, Pugh, Milligan (CR79) 1995; 17
Lange, Rigal, Clarisse, Giffard, Sevin, Barillet, Eustache, Joly (CR78) 2014; 40
Kesler, Hadi Hosseini, Heckler, Janelsins, Palesh, Mustian, Morrow (CR103) 2013; 13
Joshi, Sultana, Tangpong, Cole, St Clair, Vore, Estus, Butterfield (CR21) 2005; 39
Ki Moore, Hockenberry, Krull (CR76) 2013; 29
Silberfarb, Philibert, Levine (CR3) 1980; 137
Kimelberg, Nedergaard (CR34) 2010; 7
Ramalingayya, Cheruku, Nayak, Kishore, Shenoy, Rao, Krishnadas (CR122) 2017; 11
Usta, Ismailoglu, Bakkaloglu, Orhan, Besbas, Sahin-Erdemli, Ozen (CR58) 2004; 19
Merriman, Aouizerat, Cataldo, Dunn, Cooper, West, Paul, Baggott, Dhruva, Kober, Langford, Leutwyler, Ritchie, Abrams, Dodd, Elboim, Hamolsky, Melisko, Miaskowski (CR70) 2014; 65
Geschwind, Haman, Miller (CR10) 2007; 25
Hensley, Peterson, Silver, Larson, Schiffer, Szatrowski (CR71) 2000; 18
Moruno-Manchon, Uzor, Kesler, Wefel, Townley, Nagaraja, Pradeep, Mangala, Sood, Tsvetkov (CR60) 2018; 86
Ahles, Saykin, Noll, Furstenberg, Guerin, Cole, Mott (CR61) 2003; 12
Wang, Walitt, Saligan, Tiwari, Cheung, Zhang (CR65) 2015; 72
Seguin, Brennan, Mangano, Hayley (CR49) 2009; 5
Ahles, Saykin, McDonald, Furstenberg, Cole, Hanscom, Mulrooney, Schwartz, Kaufman (CR73) 2008; 110
Castellino, Ullrich, Whelen, Lange (CR77) 2014
Goedendorp, Knoop, Gielissen, Verhagen, Bleijenberg (CR101) 2014; 47
Hayslip, Dressler, Weiss, Taylor, Chambers, Noel, Miriyala, Keeney, Ren, Sultana, Vore, Butterfield, St Clair, Moscow (CR4) 2015; 10
Aluise, Sultana, Tangpong, Vore, St Clair, Moscow, Butterfield (CR11) 2010; 678
Kreukels, Schagen, Ridderinkhof, Boogerd, Hamburger, van Dam (CR87) 2005; 94
Lundorff, Jonsson, Sjogren (CR109) 2009; 23
Joshi, Hardas, Sultana, St Clair, Vore, Butterfield (CR22) 2007; 85
Moruno-Manchon, Uzor, Kesler, Wefel, Townley, Nagaraja, Pradeep, Mangala, Sood, Tsvetkov (CR59) 2016; 8
Tangpong, Cole, Sultana, Joshi, Estus, Vore, St Clair, Ratanachaiyavong, St Clair, Butterfield (CR15) 2006; 23
ElBeltagy, Mustafa, Umka, Lyons, Salman, Chur-yoe, Bhalla, Bennett, Wigmore (CR117) 2010; 208
Morris (CR96) 1984; 11
Belarbi, Arellano, Ferguson, Jopson, Rosi (CR51) 2012; 26
Tangpong, Miriyala, Noel, Sinthupibulyakit, Jungsuwadee, St Clair (CR57) 2011; 175
Cardoso, Santos, Carvalho, Correia, Pereira, Pereira, Oliveira, Santos, Proenca, Moreira (CR56) 2008; 45
Mostert, Koch, Heerings, Heersema, De Keyser (CR115) 2008; 14
Wefel, Vardy, Ahles, Schagen (CR85) 2011; 12
Stone, DeAngelis (CR9) 2016; 13
Kohman, Rhodes (CR48) 2013; 27
Schagen, Wefel (CR6) 2013; 11
Bigotte, Arvidson, Olsson (CR14) 1982; 57
Baune, Eyre, Jawahar, Anscomb, Körner (CR35) 2012; 3
Ferguson, McDonald, Rocque, Furstenberg, Horrigan, Ahles, Saykin (CR100) 2012; 21
Winocur, Wojtowicz, Huang, Tannock (CR105) 2014; 231
Haydon, Carmignoto (CR33) 2006; 86
Myers (CR81) 2009; 36
Squire (CR43) 1992; 99
Liedke, Reolon, Kilpp, Brunetto, Roesler, Schwartsmann (CR93) 2009; 94
Wong-Goodrich, Pfau, Flores, Fraser, Williams, Jones (CR104) 2010; 70
Byeon, le Thao, Lee, Min, Lee, Shin, Choi, Youn (CR16) 2016; 225
Mar Fan, Clemons, Xu, Chemerynsky, Breunis, Braganza, Tannock (CR111) 2008; 16
Fardell, Vardy, Johnston, Winocur (CR119) 2011; 90
Kitamura, Kanemoto, Sugimoto, Machida, Nakamura, Naito, Kanzaki, Miyazaki, Asanuma, Sendo (CR47) 2017; 390
Conroy, McDonald, Smith, Moser, West, Kamendulis, Klaunig, Champion, Unverzagt, Saykin (CR83) 2013; 137
Lawrence, Griffin, Balcueva, Groteluschen, Samuel, Lesser, Naughton, Case, Shaw, Rapp (CR114) 2016; 10
Butler, O’Connor, Moynagh (CR31) 2004; 124
Christie, Acharya, Parihar, Nguyen, Martirosian, Limoli (CR45) 2012; 18
Gold (CR36) 2003; 80
Hyka, Dayer, Modoux, Kohno, Edwards, Roux-Lombard, Burger (CR28) 2001; 97
Mustian, Peppone (CR106) 2015; 33
Brezden, Phillips, Abdolell, Bunston, Tannock (CR8) 2000; 18
Carson, Thrash, Walter (CR32) 2006; 6
Thompson, Leigh, Christensen, Xiong, Kun, Heideman, Reddick, Gajjar, Merchant, Pui, Hudson, Mulhern (CR112) 2001; 19
Tangpong, Cole, Sultana, Estus, Vore, St Clair, Ratanachaiyavong, St Clair, Butterfield (CR23) 2007; 100
Konat, Kraszpulski, James, Zhang, Abraham (CR120) 2008; 23
Ahles, Saykin (CR7) 2002; 3
Butterfield (CR26) 2014; 74
Kreukels, van Dam, Ridderinkhof, Boogerd, Schagen (CR82) 2008; 8
Blackhall, Petroni, Shu, Baum, Farace (CR110) 2009; 12
Small, Rawson, Walsh, Jim, Hughes, Iser, Andrykowski, Jacobsen (CR62) 2011; 117
Keeney, Ren, Warrier, Noel, Powell, Brelsfoard, Sultana, Saatman, Clair, Butterfield (CR27) 2018; 9
Pal, Ahir, Sil (CR37) 2012; 46
Lakshminarasimhan, Coughlin, Darr, Byrne (CR55) 2017; 7
Carvalho, Santos, Cardoso, Correia, Oliveira, Santos, Moreira (CR12) 2009; 16
Nishioku, Matsumoto, Dohgu, Sumi, Miyao, Takata, Shuto, Yamauchi, Kataoka (CR30) 2010; 112
Squire (CR44) 1993; 16
Kovalchuk, Ilnytskyy, Rodriguez-Juarez, Katz, Sidransky, Kolb, Kovalchuk (CR66) 2017; 8
McAllister, Ahles, Saykin, Ferguson, McDonald, Lewis, Flashman, Rhodes (CR64) 2004; 6
Bethus, Tse, Morris (CR41) 2010; 30
Salas-Ramirez, Bagnall, Frias, Abdali, Ahles, Hubbard (CR53) 2015; 292
Horky, Gerbaudo, Zaitsev, Plesniak, Hainer, Govindarajulu, Kikinis, Dietrich (CR90) 2014; 1
Crowgey, Peters, Hornsby, Lane, McSherry, Herndon, West, Williams, Jones (CR107) 2014; 39
Mustafa, Walker, Bennett, Wigmore (CR116) 2008; 28
Kwatra, Jangra, Mishra, Sharma, Ahmed, Ghosh, Kumar, Vohora, Khanam (CR39) 2016; 41
Moore (CR86) 2014; 28
Van Calsteren, Hartmann, Van Aerschot, Verbesselt, Van Bree, D'Hooge, Amant (CR94) 2009; 30
Ramalingayya, Sonawane, Cheruku, Kishore, Nayak, Kumar, Shenoy, Nandakumar (CR121) 2017; 36
Rebok, Ball, Guey, Jones, Kim, King, Marsiske, Morris, Tennstedt, Unverzagt, Willis (CR102) 2014; 62
Sleight (CR98) 2016; 38
Selamat, Loh, Mackenzie, Vardy (CR75) 2014; 9
Trachootham, Lu, Ogasawara, Nilsa, Huang (CR25) 2008; 10
Hess, Insel (CR68) 2007; 34
Deprez, Amant, Yigit, Porke, Verhoeven, Van den Stock, Smeets, Christiaens, Leemans, Van Hecke, Vandenberghe, Vandenbulcke, Sunaert (CR84) 2011; 32
Zimmer, Mierau, Bloch, Struder, Hulsdunker, Schenk, Fiebig, Baumann, Hahn, Reinart, Hallek, Elter (CR88) 2015; 56
Guan, Kim, Lomvardas, Holick, Xu, Kandel, Schwartz (CR54) 2003; 23
Joshi, Aluise, Cole, Sultana, Pierce, Vore, St Clair, Butterfield (CR20) 2010; 166
Winocur, Binns, Tannock (CR113) 2011; 61
Fernandez, Muzerelle, Scotto-Lomassese, Barik, Gruart, Delgado-Garcia, Gaspar (CR40) 2017; 42
Boykoff, Moieni, Subramanian (CR67) 2009; 3
Deng, Aimone, Gage (CR42) 2010; 11
Green, Rose (CR19) 2006; 1
Morley, Montgomery (CR63) 2001; 31
Gabizon (CR18) 2001; 19
Lim, Joung, Yu, Shim, Kim (CR89) 2016; 2016
Iosif, Ekdahl, Ahlenius, Pronk, Bonde, Kokaia, Jacobsen, Lindvall (CR50) 2006; 26
Wagner, Butt, Lai, Cella (CR74) 2009; 7
Ferguson, Ahles, Saykin, McDonald, Furstenberg, Cole, Mott (CR99) 2007; 16
Schmidt (CR17) 2016; 11
Kitamura, Hattori, Yoneda, Watanabe, Kanemoto, Sugimoto, Kawai, Machida, Kanzaki, Miyazaki, Asanuma, Sendo (CR46) 2015; 292
Philpot, Ficken, Wecker (CR97) 2016; 307
Cavaletti, Alberti, Marmiroli (CR1) 2015
Wefel, Lenzi, Theriault, Davis, Meyers (CR5) 2004; 100
Ahles, Root, Ryan (CR69) 2012; 30
Lyons, ElBeltagy, Bennett, Wigmore (CR118) 2012; 7
Liu, Zhang, Coughlin, Cleary, Byrne (CR52) 2014; 34
Corrie (CR2) 2008; 36
Aluise, Miriyala, Noel, Sultana, Jungsuwadee, Taylor, Cai, Pierce, Vore, Moscow, St Clair, Butterfield (CR29) 2011; 50
El-Agamy, Abdel-Aziz, Wahdan, Esmat, Azab (CR38) 2018; 55
van Dam, Schagen, Muller, Boogerd, vd Wall, Droogleever Fortuyn, Rodenhuis (CR72) 1998; 90
A Kovalchuk (3827_CR66) 2017; 8
D Trachootham (3827_CR25) 2008; 10
LM Hess (3827_CR68) 2007; 34
GW Konat (3827_CR120) 2008; 23
J Hayslip (3827_CR4) 2015; 10
C Carvalho (3827_CR12) 2009; 16
AA Gabizon (3827_CR18) 2001; 19
G Joshi (3827_CR22) 2007; 85
SM Castellino (3827_CR77) 2014
JA Lawrence (3827_CR114) 2016; 10
G Winocur (3827_CR105) 2014; 231
S Cardoso (3827_CR56) 2008; 45
G Cavaletti (3827_CR1) 2015
MD Geschwind (3827_CR10) 2007; 25
J Tangpong (3827_CR57) 2011; 175
LSJ Wagner (3827_CR74) 2009; 7
Y Kitamura (3827_CR46) 2015; 292
M Kwatra (3827_CR39) 2016; 41
SJ Thompson (3827_CR112) 2001; 19
L Blackhall (3827_CR110) 2009; 12
JF Moruno-Manchon (3827_CR59) 2016; 8
HJ Byeon (3827_CR16) 2016; 225
TA Ahles (3827_CR69) 2012; 30
XM Wang (3827_CR65) 2015; 72
ER Lenz (3827_CR79) 1995; 17
LR Squire (3827_CR43) 1992; 99
N Boykoff (3827_CR67) 2009; 3
R Morris (3827_CR96) 1984; 11
A Daiber (3827_CR24) 2013; 14
GV Ramalingayya (3827_CR122) 2017; 11
GW Rebok (3827_CR102) 2014; 62
KY Salas-Ramirez (3827_CR53) 2015; 292
JS Wefel (3827_CR85) 2011; 12
MM Goedendorp (3827_CR101) 2014; 47
K Belarbi (3827_CR51) 2012; 26
S Kohli (3827_CR108) 2009; 115
JS Myers (3827_CR81) 2009; 36
JP Mostert (3827_CR115) 2008; 14
KL Pomykala (3827_CR92) 2013; 7
G Winocur (3827_CR113) 2011; 61
M Lange (3827_CR78) 2014; 40
JTR Keeney (3827_CR27) 2018; 9
PG Haydon (3827_CR33) 2006; 86
BTCM-L Baune (3827_CR35) 2012; 3
RA Kohman (3827_CR48) 2013; 27
CD Aluise (3827_CR29) 2011; 50
DA Butterfield (3827_CR26) 2014; 74
MP Butler (3827_CR31) 2004; 124
SB Schagen (3827_CR6) 2013; 11
RJ Ferguson (3827_CR99) 2007; 16
S Mustafa (3827_CR116) 2008; 28
T Nishioku (3827_CR30) 2010; 112
Z Guan (3827_CR54) 2003; 23
CB Brezden (3827_CR8) 2000; 18
CD Aluise (3827_CR11) 2010; 678
J Tangpong (3827_CR23) 2007; 100
RE Iosif (3827_CR50) 2006; 26
HC Moore (3827_CR86) 2014; 28
PG Corrie (3827_CR2) 2008; 36
W Deng (3827_CR42) 2010; 11
PM Silberfarb (3827_CR3) 1980; 137
TW McAllister (3827_CR64) 2004; 6
A Sleight (3827_CR98) 2016; 38
A Hurria (3827_CR91) 2014; 14
RJ Ferguson (3827_CR100) 2012; 21
J Tangpong (3827_CR15) 2006; 23
JS Wefel (3827_CR5) 2004; 100
LA Christie (3827_CR45) 2012; 18
TA Ahles (3827_CR61) 2003; 12
T Crowgey (3827_CR107) 2014; 39
M ElBeltagy (3827_CR117) 2010; 208
BP Kreukels (3827_CR87) 2005; 94
K Calsteren Van (3827_CR94) 2009; 30
G Minotti (3827_CR13) 2004; 56
H Lakshminarasimhan (3827_CR55) 2017; 7
HG Mar Fan (3827_CR111) 2008; 16
HK Kimelberg (3827_CR34) 2010; 7
ER Lenz (3827_CR80) 1997; 19
KMJMC Mustian (3827_CR106) 2015; 33
BP Kreukels (3827_CR82) 2008; 8
RM Philpot (3827_CR97) 2016; 307
I Lim (3827_CR89) 2016; 2016
JE Fardell (3827_CR119) 2011; 90
S Pal (3827_CR37) 2012; 46
S Kesler (3827_CR103) 2013; 13
SJ Wong-Goodrich (3827_CR104) 2010; 70
L Lyons (3827_CR118) 2012; 7
LL Horky (3827_CR90) 2014; 1
L Bigotte (3827_CR14) 1982; 57
MH Selamat (3827_CR75) 2014; 9
P Zimmer (3827_CR88) 2015; 56
FS Dam van (3827_CR72) 1998; 90
BJ Small (3827_CR62) 2011; 117
ML Hensley (3827_CR71) 2000; 18
IM Ki Moore (3827_CR76) 2013; 29
JF Moruno-Manchon (3827_CR60) 2018; 86
JA Seguin (3827_CR49) 2009; 5
TA Ahles (3827_CR73) 2008; 110
S Deprez (3827_CR84) 2011; 32
TA Ahles (3827_CR7) 2002; 3
N Hyka (3827_CR28) 2001; 97
KI Morley (3827_CR63) 2001; 31
PE Gold (3827_CR36) 2003; 80
SK Conroy (3827_CR83) 2013; 137
PE Liedke (3827_CR93) 2009; 94
LE Lundorff (3827_CR109) 2009; 23
SP Fernandez (3827_CR40) 2017; 42
GV Ramalingayya (3827_CR121) 2017; 36
JD Merriman (3827_CR70) 2014; 65
JB Stone (3827_CR9) 2016; 13
RY Liu (3827_CR52) 2014; 34
Y Kitamura (3827_CR47) 2017; 390
Y Usta (3827_CR58) 2004; 19
G Joshi (3827_CR21) 2005; 39
SE El-Agamy (3827_CR38) 2018; 55
M Schmidt (3827_CR17) 2016; 11
I Bethus (3827_CR41) 2010; 30
RL Barry (3827_CR95) 2018; 12
MJ Carson (3827_CR32) 2006; 6
AE Green (3827_CR19) 2006; 1
G Joshi (3827_CR20) 2010; 166
LR Squire (3827_CR44) 1993; 16
References_xml – volume: 11
  start-page: 1011
  year: 2017
  end-page: 1026
  ident: CR122
  article-title: Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats
  publication-title: Drug Des Dev Ther
  doi: 10.2147/DDDT.S103511
– volume: 57
  start-page: 121
  issue: 2–3
  year: 1982
  end-page: 129
  ident: CR14
  article-title: Cytofluorescence localization of adriamycin in the nervous system. I. Distribution of the drug in the central nervous system of normal adult mice after intravenous injection
  publication-title: Acta Neuropathol
  doi: 10.1007/BF00685379
– volume: 12
  start-page: 612
  issue: 6
  year: 2003
  end-page: 619
  ident: CR61
  article-title: The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy
  publication-title: Psychooncology
  doi: 10.1002/pon.742
– volume: 17
  start-page: 1
  issue: 3
  year: 1995
  end-page: 13
  ident: CR79
  article-title: Collaborative development of middle-range nursing theories: toward a theory of unpleasant symptoms
  publication-title: ANS Adv Nurs Sci
  doi: 10.1097/00012272-199503000-00003
– volume: 29
  start-page: 248
  issue: 4
  year: 2013
  end-page: 259
  ident: CR76
  article-title: Cancer-related cognitive changes in children, adolescents and adult survivors of childhood cancers
  publication-title: Semin Oncol Nurs
  doi: 10.1016/j.soncn.2013.08.005
– volume: 11
  start-page: 22
  issue: 1
  year: 2016
  end-page: 26
  ident: CR17
  article-title: Dose-dense chemotherapy in metastatic breast cancer: shortening the time interval for a better therapeutic index
  publication-title: Breast Care (Basel, Switz)
  doi: 10.1159/000442726
– volume: 62
  start-page: 16
  issue: 1
  year: 2014
  end-page: 24
  ident: CR102
  article-title: Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults
  publication-title: J Am Geriatr Soc
  doi: 10.1111/jgs.12607
– volume: 70
  start-page: 9329
  issue: 22
  year: 2010
  end-page: 9338
  ident: CR104
  article-title: Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1854
– volume: 8
  start-page: 80
  issue: 1
  year: 2008
  end-page: 87
  ident: CR82
  article-title: Persistent neurocognitive problems after adjuvant chemotherapy for breast cancer
  publication-title: Clin Breast Cancer
  doi: 10.3816/CBC.2008.n.006
– volume: 34
  start-page: 13289
  issue: 40
  year: 2014
  end-page: 13300
  ident: CR52
  article-title: Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0538-14.2014
– volume: 292
  start-page: 133
  year: 2015
  end-page: 141
  ident: CR53
  article-title: Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.06.028
– volume: 45
  start-page: 1395
  issue: 10
  year: 2008
  end-page: 1402
  ident: CR56
  article-title: Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2008.08.008
– volume: 8
  start-page: 3507
  issue: 12
  year: 2016
  end-page: 3519
  ident: CR59
  article-title: TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.101144
– volume: 19
  start-page: 1802
  issue: 6
  year: 2001
  end-page: 1808
  ident: CR112
  article-title: Immediate neurocognitive effects of methylphenidate on learning-impaired survivors of childhood cancer
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2001.19.6.1802
– volume: 124
  start-page: 319
  issue: 2
  year: 2004
  end-page: 326
  ident: CR31
  article-title: Dissection of tumor-necrosis factor-alpha inhibition of long-term potentiation (LTP) reveals a p38 mitogen-activated protein kinase-dependent mechanism which maps to early-but not late-phase LTP
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2003.11.040
– volume: 86
  start-page: 1009
  issue: 3
  year: 2006
  end-page: 1031
  ident: CR33
  article-title: Astrocyte control of synaptic transmission and neurovascular coupling
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00049.2005
– volume: 137
  start-page: 597
  issue: 5
  year: 1980
  end-page: 601
  ident: CR3
  article-title: Psychosocial aspects of neoplastic disease: II. Affective and cognitive effects of chemotherapy in cancer patients
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.137.5.597
– volume: 32
  start-page: 480
  issue: 3
  year: 2011
  end-page: 493
  ident: CR84
  article-title: Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.21033
– volume: 16
  start-page: 772
  issue: 8
  year: 2007
  end-page: 777
  ident: CR99
  article-title: Cognitive-behavioral management of chemotherapy-related cognitive change
  publication-title: Psychooncology
  doi: 10.1002/pon.1133
– volume: 55
  start-page: 5727
  issue: 7
  year: 2018
  end-page: 5740
  ident: CR38
  article-title: Astaxanthin ameliorates doxorubicin-induced cognitive impairment (chemobrain) in experimental rat model: impact on oxidative, inflammatory, and apoptotic machineries
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-017-0797-7
– volume: 39
  start-page: 724
  issue: 6
  year: 2014
  end-page: 729
  ident: CR107
  article-title: Relationship between exercise behavior, cardiorespiratory fitness, and cognitive function in early breast cancer patients treated with doxorubicin-containing chemotherapy: a pilot study
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/apnm-2013-0380
– volume: 41
  start-page: 2352
  issue: 9
  year: 2016
  end-page: 2366
  ident: CR39
  article-title: Naringin and sertraline ameliorate doxorubicin-induced behavioral deficits through modulation of serotonin level and mitochondrial complexes protection pathway in rat hippocampus
  publication-title: Neurochem Res
  doi: 10.1007/s11064-016-1949-2
– volume: 117
  start-page: 1369
  issue: 7
  year: 2011
  end-page: 1376
  ident: CR62
  article-title: Catechol- -methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors
  publication-title: Cancer
  doi: 10.1002/cncr.25685
– volume: 307
  start-page: 165
  year: 2016
  end-page: 175
  ident: CR97
  article-title: Doxorubicin and cyclophosphamide lead to long-lasting impairment of spatial memory in female, but not male mice
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2016.04.017
– volume: 175
  start-page: 292
  year: 2011
  end-page: 299
  ident: CR57
  article-title: Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.11.007
– volume: 16
  start-page: 3267
  issue: 25
  year: 2009
  end-page: 3285
  ident: CR12
  article-title: Doxorubicin: the good, the bad and the ugly effect
  publication-title: Curr Med Chem
  doi: 10.2174/092986709788803312
– volume: 3
  start-page: 263
  year: 2012
  end-page: 277
  ident: CR35
  article-title: Tumour necrosis factor-alpha mediated mechanisms of cognitive dysfunction
  publication-title: Transl Neurosci
  doi: 10.2478/s13380-012-0027-8
– volume: 13
  start-page: 92
  issue: 2
  year: 2016
  end-page: 105
  ident: CR9
  article-title: Cancer-treatment-induced neurotoxicity—focus on newer treatments
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2015.152
– volume: 225
  start-page: 301
  year: 2016
  end-page: 313
  ident: CR16
  article-title: Doxorubicin-loaded nanoparticles consisted of cationic- and mannose-modified-albumins for dual-targeting in brain tumors
  publication-title: J Control Release Off J Control Release Soc
  doi: 10.1016/j.jconrel.2016.01.046
– volume: 65
  start-page: 192
  issue: 2
  year: 2014
  end-page: 201
  ident: CR70
  article-title: Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2013.11.003
– volume: 100
  start-page: 191
  issue: 1
  year: 2007
  end-page: 201
  ident: CR23
  article-title: Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2006.04179.x
– volume: 27
  start-page: 22
  issue: 1
  year: 2013
  end-page: 32
  ident: CR48
  article-title: Neurogenesis, inflammation and behavior
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2012.09.003
– volume: 10
  start-page: 176
  issue: 1
  year: 2016
  end-page: 184
  ident: CR114
  article-title: A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy
  publication-title: J Cancer Surviv
  doi: 10.1007/s11764-015-0463-x
– volume: 7
  start-page: W32
  issue: 6
  year: 2009
  end-page: W39
  ident: CR74
  article-title: Measuring patient self-reported cognitive function: development of the functional assessment of cancer therapy-cognitive function instrument
  publication-title: J Support Oncol
– volume: 231
  start-page: 2311
  issue: 11
  year: 2014
  end-page: 2320
  ident: CR105
  article-title: Physical exercise prevents suppression of hippocampal neurogenesis and reduces cognitive impairment in chemotherapy-treated rats
  publication-title: Psychopharmacology
  doi: 10.1007/s00213-013-3394-0
– volume: 7
  start-page: 511
  issue: 4
  year: 2013
  end-page: 523
  ident: CR92
  article-title: The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer
  publication-title: Brain Imaging Behav
  doi: 10.1007/s11682-013-9243-2
– volume: 42
  start-page: 512
  issue: 2
  year: 2017
  end-page: 523
  ident: CR40
  article-title: Constitutive and acquired serotonin deficiency alters memory and hippocampal synaptic plasticity
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.134
– volume: 6
  start-page: 364
  issue: 5
  year: 2004
  end-page: 371
  ident: CR64
  article-title: Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments
  publication-title: Curr Psychiatry Rep
  doi: 10.1007/s11920-004-0023-y
– volume: 23
  start-page: 325
  issue: 3
  year: 2008
  end-page: 333
  ident: CR120
  article-title: Cognitive dysfunction induced by chronic administration of common cancer chemotherapeutics in rats
  publication-title: Metab Brain Dis
  doi: 10.1007/s11011-008-9100-y
– volume: 137
  start-page: 493
  issue: 2
  year: 2013
  end-page: 502
  ident: CR83
  article-title: Alterations in brain structure and function in breast cancer survivors: effect of post-chemotherapy interval and relation to oxidative DNA damage
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-012-2385-x
– volume: 14
  start-page: 153
  issue: 2
  year: 2008
  end-page: 164
  ident: CR115
  article-title: Therapeutic potential of fluoxetine in neurological disorders
  publication-title: CNS Neurosci Ther
  doi: 10.1111/j.1527-3458.2008.00040.x
– volume: 6
  start-page: 237
  issue: 5
  year: 2006
  end-page: 245
  ident: CR32
  article-title: The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival
  publication-title: Clin Neurosci Res
  doi: 10.1016/j.cnr.2006.09.004
– volume: 50
  start-page: 1630
  issue: 11
  year: 2011
  end-page: 1638
  ident: CR29
  article-title: 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-alpha release: implications for the reactive oxygen species-mediated mechanisms of chemobrain
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2011.03.009
– volume: 97
  start-page: 2381
  issue: 8
  year: 2001
  end-page: 2389
  ident: CR28
  article-title: Apolipoprotein A-I inhibits the production of interleukin-1beta and tumor necrosis factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes
  publication-title: Blood
  doi: 10.1182/blood.V97.8.2381
– volume: 36
  start-page: 24
  year: 2008
  end-page: 28
  ident: CR2
  article-title: Cytotoxic chemotherapy: clinical aspects
  publication-title: Medicine
  doi: 10.1016/j.mpmed.2007.10.012
– volume: 11
  start-page: 225
  issue: 2
  year: 2013
  end-page: 232
  ident: CR6
  article-title: Chemotherapy-related changes in cognitive functioning
  publication-title: EJC Suppl EJC Off J EORTC Eur Organ Res Treat Cancer [et al]
  doi: 10.1016/j.ejcsup.2013.07.007
– volume: 678
  start-page: 147
  year: 2010
  end-page: 156
  ident: CR11
  article-title: Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4419-6306-2_19
– volume: 16
  start-page: 56
  issue: 2
  year: 1993
  end-page: 57
  ident: CR44
  article-title: The hippocampus and spatial memory
  publication-title: Trends Neurosci
  doi: 10.1016/0166-2236(93)90016-F
– volume: 14
  start-page: 7542
  issue: 4
  year: 2013
  end-page: 7570
  ident: CR24
  article-title: Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms14047542
– volume: 94
  start-page: 53
  issue: 1
  year: 2005
  end-page: 61
  ident: CR87
  article-title: Electrophysiological correlates of information processing in breast-cancer patients treated with adjuvant chemotherapy
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-005-7093-3
– volume: 28
  start-page: 797
  issue: 9
  year: 2014
  end-page: 804
  ident: CR86
  article-title: An overview of chemotherapy-related cognitive dysfunction, or ‘chemobrain’
  publication-title: Oncology (Williston Park)
– year: 2014
  ident: CR77
  article-title: Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/dju186
– volume: 208
  start-page: 112
  issue: 1
  year: 2010
  end-page: 117
  ident: CR117
  article-title: Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2009.11.017
– volume: 36
  start-page: E1
  issue: 1
  year: 2009
  end-page: 10
  ident: CR81
  article-title: A comparison of the theory of unpleasant symptoms and the conceptual model of chemotherapy-related changes in cognitive function
  publication-title: Oncol Nurs Forum
  doi: 10.1188/09.onf.e1-e10
– volume: 19
  start-page: 424
  issue: 4
  year: 2001
  end-page: 436
  ident: CR18
  article-title: Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy
  publication-title: Cancer Investig
  doi: 10.1081/CNV-100103136
– volume: 12
  start-page: 433
  issue: 5
  year: 2009
  end-page: 439
  ident: CR110
  article-title: A pilot study evaluating the safety and efficacy of modafinal for cancer-related fatigue
  publication-title: J Palliat Med
  doi: 10.1089/jpm.2008.0230
– volume: 38
  start-page: 400
  issue: 4
  year: 2016
  end-page: 408
  ident: CR98
  article-title: Coping with cancer-related cognitive dysfunction: a scoping review of the literature
  publication-title: Disabil Rehabil
  doi: 10.3109/09638288.2015.1038364
– volume: 7
  start-page: 4533
  issue: 1
  year: 2017
  ident: CR55
  article-title: Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-04634-4
– volume: 13
  start-page: 299
  issue: 4
  year: 2013
  end-page: 306
  ident: CR103
  article-title: Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors
  publication-title: Clin Breast Cancer
  doi: 10.1016/j.clbc.2013.02.004
– volume: 72
  start-page: 86
  issue: 1
  year: 2015
  end-page: 96
  ident: CR65
  article-title: Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.12.006
– volume: 390
  start-page: 369
  issue: 4
  year: 2017
  end-page: 378
  ident: CR47
  article-title: Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-016-1338-z
– volume: 56
  start-page: 347
  issue: 2
  year: 2015
  end-page: 352
  ident: CR88
  article-title: Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine
  publication-title: Leuk Lymphoma
  doi: 10.3109/10428194.2014.915546
– volume: 26
  start-page: 9703
  issue: 38
  year: 2006
  end-page: 9712
  ident: CR50
  article-title: Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2723-06.2006
– volume: 3
  start-page: 223
  issue: 4
  year: 2009
  end-page: 232
  ident: CR67
  article-title: Confronting chemobrain: an in-depth look at survivors' reports of impact on work, social networks, and health care response
  publication-title: J Cancer Surviv
  doi: 10.1007/s11764-009-0098-x
– volume: 7
  start-page: 338
  issue: 4
  year: 2010
  end-page: 353
  ident: CR34
  article-title: Functions of astrocytes and their potential as therapeutic targets
  publication-title: Neurotherapeutics
  doi: 10.1016/j.nurt.2010.07.006
– volume: 47
  start-page: 35
  issue: 1
  year: 2014
  end-page: 44
  ident: CR101
  article-title: The effects of cognitive behavioral therapy for postcancer fatigue on perceived cognitive disabilities and neuropsychological test performance
  publication-title: J Pain Symptom Manag
  doi: 10.1016/j.jpainsymman.2013.02.014
– volume: 23
  start-page: 731
  issue: 8
  year: 2009
  end-page: 738
  ident: CR109
  article-title: Modafinil for attentional and psychomotor dysfunction in advanced cancer: a double-blind, randomised, cross-over trial
  publication-title: Palliat Med
  doi: 10.1177/0269216309106872
– volume: 18
  start-page: 2695
  issue: 14
  year: 2000
  end-page: 2701
  ident: CR8
  article-title: Cognitive function in breast cancer patients receiving adjuvant chemotherapy
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2000.18.14.2695
– volume: 34
  start-page: 981
  issue: 5
  year: 2007
  end-page: 994
  ident: CR68
  article-title: Chemotherapy-related change in cognitive function: a conceptual model
  publication-title: Oncol Nurs Forum
  doi: 10.1188/07.onf.981-994
– volume: 1
  start-page: 788
  issue: 10
  year: 2014
  end-page: 798
  ident: CR90
  article-title: Systemic chemotherapy decreases brain glucose metabolism
  publication-title: Ann Clin Transl Neurol
  doi: 10.1002/acn3.121
– volume: 7
  start-page: e30010
  issue: 1
  year: 2012
  ident: CR118
  article-title: Fluoxetine counteracts the cognitive and cellular effects of 5-fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0030010
– volume: 1
  start-page: 229
  issue: 3
  year: 2006
  end-page: 239
  ident: CR19
  article-title: Pegylated liposomal doxorubicin in ovarian cancer
  publication-title: Int J Nanomed
– volume: 18
  start-page: 1954
  issue: 7
  year: 2012
  end-page: 1965
  ident: CR45
  article-title: Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-2000
– volume: 86
  start-page: 65
  year: 2018
  end-page: 71
  ident: CR60
  article-title: Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2017.11.014
– volume: 100
  start-page: 2292
  issue: 11
  year: 2004
  end-page: 2299
  ident: CR5
  article-title: The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial
  publication-title: Cancer
  doi: 10.1002/cncr.20272
– volume: 166
  start-page: 796
  issue: 3
  year: 2010
  end-page: 807
  ident: CR20
  article-title: Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.01.021
– volume: 2016
  start-page: 6945415
  year: 2016
  ident: CR89
  article-title: PET evidence of the effect of donepezil on cognitive performance in an animal model of chemobrain
  publication-title: Biomed Res Int
  doi: 10.1155/2016/6945415
– volume: 292
  start-page: 184
  year: 2015
  end-page: 193
  ident: CR46
  article-title: Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.06.007
– volume: 3
  start-page: S84
  issue: Suppl 3
  year: 2002
  end-page: S90
  ident: CR7
  article-title: Breast cancer chemotherapy-related cognitive dysfunction
  publication-title: Clin Breast Cancer
  doi: 10.3816/CBC.2002.s.018
– volume: 18
  start-page: 1301
  issue: 6
  year: 2000
  end-page: 1308
  ident: CR71
  article-title: Risk factors for severe neuropsychiatric toxicity in patients receiving interferon alfa-2b and low-dose cytarabine for chronic myelogenous leukemia: analysis of Cancer and Leukemia Group B 9013
  publication-title: J Clin Oncol Off J Am Soc Clin Oncol
  doi: 10.1200/jco.2000.18.6.1301
– volume: 94
  start-page: 239
  issue: 2
  year: 2009
  end-page: 243
  ident: CR93
  article-title: Systemic administration of doxorubicin impairs aversively motivated memory in rats
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2009.09.001
– volume: 46
  start-page: 785
  issue: 6
  year: 2012
  end-page: 798
  ident: CR37
  article-title: Doxorubicin-induced neurotoxicity is attenuated by a 43-kD protein from the leaves of L. via NF-kappaB and mitochondria dependent pathways
  publication-title: Free Radic Res
  doi: 10.3109/10715762.2012.678841
– volume: 31
  start-page: 511
  issue: 6
  year: 2001
  end-page: 531
  ident: CR63
  article-title: The genetics of cognitive processes: candidate genes in humans and animals
  publication-title: Behav Genet
  doi: 10.1023/A:1013337209957
– volume: 8
  start-page: 88276
  issue: 51
  year: 2017
  end-page: 88293
  ident: CR66
  article-title: Growth of malignant extracranial tumors alters microRNAome in the prefrontal cortex of TumorGraft mice
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19835
– volume: 28
  start-page: 323
  issue: 2
  year: 2008
  end-page: 330
  ident: CR116
  article-title: 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2008.06325.x
– volume: 36
  start-page: 121
  issue: 2
  year: 2017
  end-page: 130
  ident: CR121
  article-title: Insulin protects against brain oxidative stress with an apparent effect on episodic memory in doxorubicin-induced cognitive dysfunction in Wistar rats
  publication-title: J Environ Pathol Toxicol Oncol
  doi: 10.1615/JEnvironPatholToxicolOncol.2017017087
– volume: 56
  start-page: 185
  issue: 2
  year: 2004
  end-page: 229
  ident: CR13
  article-title: Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.56.2.6
– volume: 19
  start-page: 14
  issue: 3
  year: 1997
  end-page: 27
  ident: CR80
  article-title: The middle-range theory of unpleasant symptoms: an update
  publication-title: ANS Adv Nurs Sci
  doi: 10.1097/00012272-199703000-00003
– volume: 10
  start-page: e0124988
  issue: 4
  year: 2015
  ident: CR4
  article-title: Plasma TNF-alpha and soluble TNF receptor levels after doxorubicin with or without co-administration of Mesna—a randomized cross-over clinical study
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0124988
– volume: 40
  start-page: 810
  issue: 6
  year: 2014
  end-page: 817
  ident: CR78
  article-title: Cognitive dysfunctions in elderly cancer patients: a new challenge for oncologists
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2014.03.003
– volume: 80
  start-page: 194
  issue: 3
  year: 2003
  end-page: 210
  ident: CR36
  article-title: Acetylcholine modulation of neural systems involved in learning and memory
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2003.07.003
– volume: 5
  start-page: 5
  year: 2009
  end-page: 14
  ident: CR49
  article-title: Proinflammatory cytokines differentially influence adult hippocampal cell proliferation depending upon the route and chronicity of administration
  publication-title: Neuropsychiatr Dis Treat
– volume: 9
  start-page: e108002
  issue: 9
  year: 2014
  ident: CR75
  article-title: Chemobrain experienced by breast cancer survivors: a meta-ethnography study investigating research and care implications
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0108002
– volume: 25
  start-page: 783-vii
  issue: 3
  year: 2007
  ident: CR10
  article-title: Rapidly progressive dementia
  publication-title: Neurol Clin
  doi: 10.1016/j.ncl.2007.04.001
– volume: 39
  start-page: 1147
  issue: 11
  year: 2005
  end-page: 1154
  ident: CR21
  article-title: Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: insight into chemobrain
  publication-title: Free Radic Res
  doi: 10.1080/10715760500143478
– volume: 112
  start-page: 251
  issue: 2
  year: 2010
  end-page: 254
  ident: CR30
  article-title: Tumor necrosis factor-alpha mediates the blood-brain barrier dysfunction induced by activated microglia in mouse brain microvascular endothelial cells
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.09292SC
– volume: 110
  start-page: 143
  issue: 1
  year: 2008
  end-page: 152
  ident: CR73
  article-title: Cognitive function in breast cancer patients prior to adjuvant treatment
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-007-9686-5
– volume: 74
  start-page: 157
  year: 2014
  end-page: 174
  ident: CR26
  article-title: The 2013 SFRBM discovery award: selected discoveries from the Butterfield Laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2014.06.006
– volume: 115
  start-page: 2605
  issue: 12
  year: 2009
  end-page: 2616
  ident: CR108
  article-title: The effect of modafinil on cognitive function in breast cancer survivors
  publication-title: Cancer
  doi: 10.1002/cncr.24287
– volume: 61
  start-page: 1222
  issue: 8
  year: 2011
  end-page: 1228
  ident: CR113
  article-title: Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.07.013
– volume: 85
  start-page: 497
  issue: 3
  year: 2007
  end-page: 503
  ident: CR22
  article-title: Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: implication for chemobrain
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.21158
– volume: 11
  start-page: 339
  issue: 5
  year: 2010
  end-page: 350
  ident: CR42
  article-title: New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2822
– volume: 14
  start-page: 132
  issue: 2
  year: 2014
  end-page: 140
  ident: CR91
  article-title: The effect of aromatase inhibition on the cognitive function of older patients with breast cancer
  publication-title: Clin Breast Cancer
  doi: 10.1016/j.clbc.2013.10.010
– volume: 21
  start-page: 176
  issue: 2
  year: 2012
  end-page: 186
  ident: CR100
  article-title: Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial
  publication-title: Psychooncology
  doi: 10.1002/pon.1878
– volume: 16
  start-page: 577
  issue: 6
  year: 2008
  end-page: 583
  ident: CR111
  article-title: A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-007-0341-9
– volume: 10
  start-page: 1343
  issue: 8
  year: 2008
  end-page: 1374
  ident: CR25
  article-title: Redox regulation of cell survival
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2007.1957
– volume: 30
  start-page: 1610
  issue: 5
  year: 2010
  end-page: 1618
  ident: CR41
  article-title: Dopamine and memory: modulation of the persistence of memory for novel hippocampal NMDA receptor-dependent paired associates
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2721-09.2010
– volume: 26
  start-page: 18
  issue: 1
  year: 2012
  end-page: 23
  ident: CR51
  article-title: Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2011.07.225
– volume: 12
  start-page: 703
  issue: 7
  year: 2011
  end-page: 708
  ident: CR85
  article-title: International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(10)70294-1
– volume: 90
  start-page: 366
  issue: 3
  year: 2011
  end-page: 376
  ident: CR119
  article-title: Chemotherapy and cognitive impairment: treatment options
  publication-title: Clin Pharmacol Ther
  doi: 10.1038/clpt.2011.112
– volume: 90
  start-page: 210
  issue: 3
  year: 1998
  end-page: 218
  ident: CR72
  article-title: Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/90.3.210
– volume: 33
  start-page: 9504
  issue: 15 suppl
  year: 2015
  ident: CR106
  article-title: EXCAP exercise effects on cognitive impairment and inflammation: a URCC NCORP RCT in 479 cancer patients
  publication-title: J Clin Oncol
  doi: 10.1200/jco.2015.33.15_suppl.9504
– volume: 23
  start-page: 127
  issue: 1
  year: 2006
  end-page: 139
  ident: CR15
  article-title: Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2006.02.013
– volume: 23
  start-page: 7317
  issue: 19
  year: 2003
  end-page: 7325
  ident: CR54
  article-title: p38 MAP kinase mediates both short-term and long-term synaptic depression in aplysia
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-19-07317.2003
– volume: 19
  start-page: 840
  issue: 8
  year: 2004
  end-page: 843
  ident: CR58
  article-title: Effects of pentoxifylline in adriamycin-induced renal disease in rats
  publication-title: Pediatr Nephrol
  doi: 10.1007/s00467-004-1538-5
– volume: 12
  start-page: 87
  issue: 1
  year: 2018
  end-page: 95
  ident: CR95
  article-title: In vivo neuroimaging and behavioral correlates in a rat model of chemotherapy-induced cognitive dysfunction
  publication-title: Brain Imaging Behav
  doi: 10.1007/s11682-017-9674-2
– volume: 30
  start-page: 3675
  issue: 30
  year: 2012
  end-page: 3686
  ident: CR69
  article-title: Cancer- and cancer treatment-associated cognitive change: an update on the state of the science
  publication-title: J Clin Oncol Off J Am Soc Clin Onc
  doi: 10.1200/jco.2012.43.0116
– volume: 30
  start-page: 647
  issue: 4
  year: 2009
  end-page: 657
  ident: CR94
  article-title: Vinblastine and doxorubicin administration to pregnant mice affects brain development and behaviour in the offspring
  publication-title: NeuroToxicology
  doi: 10.1016/j.neuro.2009.04.009
– year: 2015
  ident: CR1
  article-title: Chemotherapy-induced peripheral neurotoxicity in cancer survivors: an underdiagnosed clinical entity?
  publication-title: Am Soc Clin Oncol Educ Book
  doi: 10.14694/EdBook_AM.2015.35.e553
– volume: 9
  start-page: 30324
  issue: 54
  year: 2018
  end-page: 30339
  ident: CR27
  article-title: Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.25718
– volume: 11
  start-page: 47
  issue: 1
  year: 1984
  end-page: 60
  ident: CR96
  article-title: Developments of a water-maze procedure for studying spatial learning in the rat
  publication-title: J Neurosci Methods
  doi: 10.1016/0165-0270(84)90007-4
– volume: 99
  start-page: 195
  issue: 2
  year: 1992
  end-page: 231
  ident: CR43
  article-title: Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans
  publication-title: Psychol Rev
  doi: 10.1037/0033-295X.99.2.195
– volume: 23
  start-page: 127
  issue: 1
  year: 2006
  ident: 3827_CR15
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2006.02.013
– volume: 29
  start-page: 248
  issue: 4
  year: 2013
  ident: 3827_CR76
  publication-title: Semin Oncol Nurs
  doi: 10.1016/j.soncn.2013.08.005
– volume: 17
  start-page: 1
  issue: 3
  year: 1995
  ident: 3827_CR79
  publication-title: ANS Adv Nurs Sci
  doi: 10.1097/00012272-199503000-00003
– volume: 1
  start-page: 229
  issue: 3
  year: 2006
  ident: 3827_CR19
  publication-title: Int J Nanomed
– volume: 7
  start-page: 4533
  issue: 1
  year: 2017
  ident: 3827_CR55
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-04634-4
– volume: 18
  start-page: 1301
  issue: 6
  year: 2000
  ident: 3827_CR71
  publication-title: J Clin Oncol Off J Am Soc Clin Oncol
  doi: 10.1200/jco.2000.18.6.1301
– volume: 94
  start-page: 53
  issue: 1
  year: 2005
  ident: 3827_CR87
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-005-7093-3
– volume: 74
  start-page: 157
  year: 2014
  ident: 3827_CR26
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2014.06.006
– volume: 28
  start-page: 797
  issue: 9
  year: 2014
  ident: 3827_CR86
  publication-title: Oncology (Williston Park)
– volume: 23
  start-page: 731
  issue: 8
  year: 2009
  ident: 3827_CR109
  publication-title: Palliat Med
  doi: 10.1177/0269216309106872
– volume: 19
  start-page: 840
  issue: 8
  year: 2004
  ident: 3827_CR58
  publication-title: Pediatr Nephrol
  doi: 10.1007/s00467-004-1538-5
– volume: 19
  start-page: 14
  issue: 3
  year: 1997
  ident: 3827_CR80
  publication-title: ANS Adv Nurs Sci
  doi: 10.1097/00012272-199703000-00003
– volume: 137
  start-page: 493
  issue: 2
  year: 2013
  ident: 3827_CR83
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-012-2385-x
– volume: 21
  start-page: 176
  issue: 2
  year: 2012
  ident: 3827_CR100
  publication-title: Psychooncology
  doi: 10.1002/pon.1878
– volume: 85
  start-page: 497
  issue: 3
  year: 2007
  ident: 3827_CR22
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.21158
– volume: 72
  start-page: 86
  issue: 1
  year: 2015
  ident: 3827_CR65
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.12.006
– volume: 45
  start-page: 1395
  issue: 10
  year: 2008
  ident: 3827_CR56
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2008.08.008
– volume: 90
  start-page: 210
  issue: 3
  year: 1998
  ident: 3827_CR72
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/90.3.210
– volume: 110
  start-page: 143
  issue: 1
  year: 2008
  ident: 3827_CR73
  publication-title: Breast Cancer Res Treat
  doi: 10.1007/s10549-007-9686-5
– volume: 225
  start-page: 301
  year: 2016
  ident: 3827_CR16
  publication-title: J Control Release Off J Control Release Soc
  doi: 10.1016/j.jconrel.2016.01.046
– volume: 31
  start-page: 511
  issue: 6
  year: 2001
  ident: 3827_CR63
  publication-title: Behav Genet
  doi: 10.1023/A:1013337209957
– volume: 86
  start-page: 1009
  issue: 3
  year: 2006
  ident: 3827_CR33
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00049.2005
– volume: 16
  start-page: 56
  issue: 2
  year: 1993
  ident: 3827_CR44
  publication-title: Trends Neurosci
  doi: 10.1016/0166-2236(93)90016-F
– volume: 124
  start-page: 319
  issue: 2
  year: 2004
  ident: 3827_CR31
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2003.11.040
– volume: 3
  start-page: 263
  year: 2012
  ident: 3827_CR35
  publication-title: Transl Neurosci
  doi: 10.2478/s13380-012-0027-8
– volume: 39
  start-page: 1147
  issue: 11
  year: 2005
  ident: 3827_CR21
  publication-title: Free Radic Res
  doi: 10.1080/10715760500143478
– volume: 100
  start-page: 191
  issue: 1
  year: 2007
  ident: 3827_CR23
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2006.04179.x
– volume: 10
  start-page: 176
  issue: 1
  year: 2016
  ident: 3827_CR114
  publication-title: J Cancer Surviv
  doi: 10.1007/s11764-015-0463-x
– volume: 292
  start-page: 133
  year: 2015
  ident: 3827_CR53
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.06.028
– volume: 6
  start-page: 237
  issue: 5
  year: 2006
  ident: 3827_CR32
  publication-title: Clin Neurosci Res
  doi: 10.1016/j.cnr.2006.09.004
– volume: 38
  start-page: 400
  issue: 4
  year: 2016
  ident: 3827_CR98
  publication-title: Disabil Rehabil
  doi: 10.3109/09638288.2015.1038364
– year: 2014
  ident: 3827_CR77
  publication-title: J Natl Cancer Inst
  doi: 10.1093/jnci/dju186
– volume: 115
  start-page: 2605
  issue: 12
  year: 2009
  ident: 3827_CR108
  publication-title: Cancer
  doi: 10.1002/cncr.24287
– volume: 19
  start-page: 424
  issue: 4
  year: 2001
  ident: 3827_CR18
  publication-title: Cancer Investig
  doi: 10.1081/CNV-100103136
– volume: 10
  start-page: 1343
  issue: 8
  year: 2008
  ident: 3827_CR25
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2007.1957
– volume: 30
  start-page: 1610
  issue: 5
  year: 2010
  ident: 3827_CR41
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2721-09.2010
– volume: 12
  start-page: 433
  issue: 5
  year: 2009
  ident: 3827_CR110
  publication-title: J Palliat Med
  doi: 10.1089/jpm.2008.0230
– volume: 57
  start-page: 121
  issue: 2–3
  year: 1982
  ident: 3827_CR14
  publication-title: Acta Neuropathol
  doi: 10.1007/BF00685379
– volume: 41
  start-page: 2352
  issue: 9
  year: 2016
  ident: 3827_CR39
  publication-title: Neurochem Res
  doi: 10.1007/s11064-016-1949-2
– year: 2015
  ident: 3827_CR1
  publication-title: Am Soc Clin Oncol Educ Book
  doi: 10.14694/EdBook_AM.2015.35.e553
– volume: 34
  start-page: 13289
  issue: 40
  year: 2014
  ident: 3827_CR52
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0538-14.2014
– volume: 137
  start-page: 597
  issue: 5
  year: 1980
  ident: 3827_CR3
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.137.5.597
– volume: 11
  start-page: 225
  issue: 2
  year: 2013
  ident: 3827_CR6
  publication-title: EJC Suppl EJC Off J EORTC Eur Organ Res Treat Cancer [et al]
  doi: 10.1016/j.ejcsup.2013.07.007
– volume: 9
  start-page: 30324
  issue: 54
  year: 2018
  ident: 3827_CR27
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.25718
– volume: 8
  start-page: 88276
  issue: 51
  year: 2017
  ident: 3827_CR66
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.19835
– volume: 9
  start-page: e108002
  issue: 9
  year: 2014
  ident: 3827_CR75
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0108002
– volume: 90
  start-page: 366
  issue: 3
  year: 2011
  ident: 3827_CR119
  publication-title: Clin Pharmacol Ther
  doi: 10.1038/clpt.2011.112
– volume: 36
  start-page: 121
  issue: 2
  year: 2017
  ident: 3827_CR121
  publication-title: J Environ Pathol Toxicol Oncol
  doi: 10.1615/JEnvironPatholToxicolOncol.2017017087
– volume: 231
  start-page: 2311
  issue: 11
  year: 2014
  ident: 3827_CR105
  publication-title: Psychopharmacology
  doi: 10.1007/s00213-013-3394-0
– volume: 14
  start-page: 153
  issue: 2
  year: 2008
  ident: 3827_CR115
  publication-title: CNS Neurosci Ther
  doi: 10.1111/j.1527-3458.2008.00040.x
– volume: 678
  start-page: 147
  year: 2010
  ident: 3827_CR11
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4419-6306-2_19
– volume: 7
  start-page: e30010
  issue: 1
  year: 2012
  ident: 3827_CR118
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0030010
– volume: 99
  start-page: 195
  issue: 2
  year: 1992
  ident: 3827_CR43
  publication-title: Psychol Rev
  doi: 10.1037/0033-295X.99.2.195
– volume: 28
  start-page: 323
  issue: 2
  year: 2008
  ident: 3827_CR116
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2008.06325.x
– volume: 8
  start-page: 80
  issue: 1
  year: 2008
  ident: 3827_CR82
  publication-title: Clin Breast Cancer
  doi: 10.3816/CBC.2008.n.006
– volume: 16
  start-page: 577
  issue: 6
  year: 2008
  ident: 3827_CR111
  publication-title: Support Care Cancer
  doi: 10.1007/s00520-007-0341-9
– volume: 47
  start-page: 35
  issue: 1
  year: 2014
  ident: 3827_CR101
  publication-title: J Pain Symptom Manag
  doi: 10.1016/j.jpainsymman.2013.02.014
– volume: 26
  start-page: 18
  issue: 1
  year: 2012
  ident: 3827_CR51
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2011.07.225
– volume: 16
  start-page: 772
  issue: 8
  year: 2007
  ident: 3827_CR99
  publication-title: Psychooncology
  doi: 10.1002/pon.1133
– volume: 23
  start-page: 7317
  issue: 19
  year: 2003
  ident: 3827_CR54
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.23-19-07317.2003
– volume: 36
  start-page: 24
  year: 2008
  ident: 3827_CR2
  publication-title: Medicine
  doi: 10.1016/j.mpmed.2007.10.012
– volume: 40
  start-page: 810
  issue: 6
  year: 2014
  ident: 3827_CR78
  publication-title: Cancer Treat Rev
  doi: 10.1016/j.ctrv.2014.03.003
– volume: 6
  start-page: 364
  issue: 5
  year: 2004
  ident: 3827_CR64
  publication-title: Curr Psychiatry Rep
  doi: 10.1007/s11920-004-0023-y
– volume: 16
  start-page: 3267
  issue: 25
  year: 2009
  ident: 3827_CR12
  publication-title: Curr Med Chem
  doi: 10.2174/092986709788803312
– volume: 25
  start-page: 783-vii
  issue: 3
  year: 2007
  ident: 3827_CR10
  publication-title: Neurol Clin
  doi: 10.1016/j.ncl.2007.04.001
– volume: 27
  start-page: 22
  issue: 1
  year: 2013
  ident: 3827_CR48
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2012.09.003
– volume: 12
  start-page: 612
  issue: 6
  year: 2003
  ident: 3827_CR61
  publication-title: Psychooncology
  doi: 10.1002/pon.742
– volume: 11
  start-page: 1011
  year: 2017
  ident: 3827_CR122
  publication-title: Drug Des Dev Ther
  doi: 10.2147/DDDT.S103511
– volume: 18
  start-page: 2695
  issue: 14
  year: 2000
  ident: 3827_CR8
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2000.18.14.2695
– volume: 56
  start-page: 185
  issue: 2
  year: 2004
  ident: 3827_CR13
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.56.2.6
– volume: 80
  start-page: 194
  issue: 3
  year: 2003
  ident: 3827_CR36
  publication-title: Neurobiol Learn Mem
  doi: 10.1016/j.nlm.2003.07.003
– volume: 26
  start-page: 9703
  issue: 38
  year: 2006
  ident: 3827_CR50
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2723-06.2006
– volume: 33
  start-page: 9504
  issue: 15 suppl
  year: 2015
  ident: 3827_CR106
  publication-title: J Clin Oncol
  doi: 10.1200/jco.2015.33.15_suppl.9504
– volume: 390
  start-page: 369
  issue: 4
  year: 2017
  ident: 3827_CR47
  publication-title: Naunyn Schmiedebergs Arch Pharmacol
  doi: 10.1007/s00210-016-1338-z
– volume: 32
  start-page: 480
  issue: 3
  year: 2011
  ident: 3827_CR84
  publication-title: Hum Brain Mapp
  doi: 10.1002/hbm.21033
– volume: 12
  start-page: 703
  issue: 7
  year: 2011
  ident: 3827_CR85
  publication-title: Lancet Oncol
  doi: 10.1016/S1470-2045(10)70294-1
– volume: 36
  start-page: E1
  issue: 1
  year: 2009
  ident: 3827_CR81
  publication-title: Oncol Nurs Forum
  doi: 10.1188/09.onf.e1-e10
– volume: 42
  start-page: 512
  issue: 2
  year: 2017
  ident: 3827_CR40
  publication-title: Neuropsychopharmacology
  doi: 10.1038/npp.2016.134
– volume: 208
  start-page: 112
  issue: 1
  year: 2010
  ident: 3827_CR117
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2009.11.017
– volume: 11
  start-page: 339
  issue: 5
  year: 2010
  ident: 3827_CR42
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2822
– volume: 100
  start-page: 2292
  issue: 11
  year: 2004
  ident: 3827_CR5
  publication-title: Cancer
  doi: 10.1002/cncr.20272
– volume: 18
  start-page: 1954
  issue: 7
  year: 2012
  ident: 3827_CR45
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-11-2000
– volume: 2016
  start-page: 6945415
  year: 2016
  ident: 3827_CR89
  publication-title: Biomed Res Int
  doi: 10.1155/2016/6945415
– volume: 50
  start-page: 1630
  issue: 11
  year: 2011
  ident: 3827_CR29
  publication-title: Free Radic Biol Med
  doi: 10.1016/j.freeradbiomed.2011.03.009
– volume: 7
  start-page: W32
  issue: 6
  year: 2009
  ident: 3827_CR74
  publication-title: J Support Oncol
– volume: 3
  start-page: 223
  issue: 4
  year: 2009
  ident: 3827_CR67
  publication-title: J Cancer Surviv
  doi: 10.1007/s11764-009-0098-x
– volume: 30
  start-page: 647
  issue: 4
  year: 2009
  ident: 3827_CR94
  publication-title: NeuroToxicology
  doi: 10.1016/j.neuro.2009.04.009
– volume: 13
  start-page: 299
  issue: 4
  year: 2013
  ident: 3827_CR103
  publication-title: Clin Breast Cancer
  doi: 10.1016/j.clbc.2013.02.004
– volume: 62
  start-page: 16
  issue: 1
  year: 2014
  ident: 3827_CR102
  publication-title: J Am Geriatr Soc
  doi: 10.1111/jgs.12607
– volume: 12
  start-page: 87
  issue: 1
  year: 2018
  ident: 3827_CR95
  publication-title: Brain Imaging Behav
  doi: 10.1007/s11682-017-9674-2
– volume: 175
  start-page: 292
  year: 2011
  ident: 3827_CR57
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.11.007
– volume: 86
  start-page: 65
  year: 2018
  ident: 3827_CR60
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2017.11.014
– volume: 3
  start-page: S84
  issue: Suppl 3
  year: 2002
  ident: 3827_CR7
  publication-title: Clin Breast Cancer
  doi: 10.3816/CBC.2002.s.018
– volume: 65
  start-page: 192
  issue: 2
  year: 2014
  ident: 3827_CR70
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2013.11.003
– volume: 56
  start-page: 347
  issue: 2
  year: 2015
  ident: 3827_CR88
  publication-title: Leuk Lymphoma
  doi: 10.3109/10428194.2014.915546
– volume: 34
  start-page: 981
  issue: 5
  year: 2007
  ident: 3827_CR68
  publication-title: Oncol Nurs Forum
  doi: 10.1188/07.onf.981-994
– volume: 1
  start-page: 788
  issue: 10
  year: 2014
  ident: 3827_CR90
  publication-title: Ann Clin Transl Neurol
  doi: 10.1002/acn3.121
– volume: 292
  start-page: 184
  year: 2015
  ident: 3827_CR46
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2015.06.007
– volume: 117
  start-page: 1369
  issue: 7
  year: 2011
  ident: 3827_CR62
  publication-title: Cancer
  doi: 10.1002/cncr.25685
– volume: 55
  start-page: 5727
  issue: 7
  year: 2018
  ident: 3827_CR38
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-017-0797-7
– volume: 11
  start-page: 47
  issue: 1
  year: 1984
  ident: 3827_CR96
  publication-title: J Neurosci Methods
  doi: 10.1016/0165-0270(84)90007-4
– volume: 14
  start-page: 132
  issue: 2
  year: 2014
  ident: 3827_CR91
  publication-title: Clin Breast Cancer
  doi: 10.1016/j.clbc.2013.10.010
– volume: 7
  start-page: 338
  issue: 4
  year: 2010
  ident: 3827_CR34
  publication-title: Neurotherapeutics
  doi: 10.1016/j.nurt.2010.07.006
– volume: 7
  start-page: 511
  issue: 4
  year: 2013
  ident: 3827_CR92
  publication-title: Brain Imaging Behav
  doi: 10.1007/s11682-013-9243-2
– volume: 19
  start-page: 1802
  issue: 6
  year: 2001
  ident: 3827_CR112
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2001.19.6.1802
– volume: 30
  start-page: 3675
  issue: 30
  year: 2012
  ident: 3827_CR69
  publication-title: J Clin Oncol Off J Am Soc Clin Onc
  doi: 10.1200/jco.2012.43.0116
– volume: 94
  start-page: 239
  issue: 2
  year: 2009
  ident: 3827_CR93
  publication-title: Pharmacol Biochem Behav
  doi: 10.1016/j.pbb.2009.09.001
– volume: 61
  start-page: 1222
  issue: 8
  year: 2011
  ident: 3827_CR113
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2011.07.013
– volume: 14
  start-page: 7542
  issue: 4
  year: 2013
  ident: 3827_CR24
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms14047542
– volume: 46
  start-page: 785
  issue: 6
  year: 2012
  ident: 3827_CR37
  publication-title: Free Radic Res
  doi: 10.3109/10715762.2012.678841
– volume: 11
  start-page: 22
  issue: 1
  year: 2016
  ident: 3827_CR17
  publication-title: Breast Care (Basel, Switz)
  doi: 10.1159/000442726
– volume: 5
  start-page: 5
  year: 2009
  ident: 3827_CR49
  publication-title: Neuropsychiatr Dis Treat
– volume: 13
  start-page: 92
  issue: 2
  year: 2016
  ident: 3827_CR9
  publication-title: Nat Rev Clin Oncol
  doi: 10.1038/nrclinonc.2015.152
– volume: 8
  start-page: 3507
  issue: 12
  year: 2016
  ident: 3827_CR59
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.101144
– volume: 39
  start-page: 724
  issue: 6
  year: 2014
  ident: 3827_CR107
  publication-title: Appl Physiol Nutr Metab
  doi: 10.1139/apnm-2013-0380
– volume: 70
  start-page: 9329
  issue: 22
  year: 2010
  ident: 3827_CR104
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-10-1854
– volume: 307
  start-page: 165
  year: 2016
  ident: 3827_CR97
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2016.04.017
– volume: 166
  start-page: 796
  issue: 3
  year: 2010
  ident: 3827_CR20
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.01.021
– volume: 97
  start-page: 2381
  issue: 8
  year: 2001
  ident: 3827_CR28
  publication-title: Blood
  doi: 10.1182/blood.V97.8.2381
– volume: 112
  start-page: 251
  issue: 2
  year: 2010
  ident: 3827_CR30
  publication-title: J Pharmacol Sci
  doi: 10.1254/jphs.09292SC
– volume: 23
  start-page: 325
  issue: 3
  year: 2008
  ident: 3827_CR120
  publication-title: Metab Brain Dis
  doi: 10.1007/s11011-008-9100-y
– volume: 10
  start-page: e0124988
  issue: 4
  year: 2015
  ident: 3827_CR4
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0124988
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SubjectTerms Animals
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - adverse effects
Brain - physiopathology
Cancer
Cancer Research
Chemotherapy
Cognition - drug effects
Cognition Disorders - chemically induced
Cognition Disorders - physiopathology
Cognitive ability
Doxorubicin
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Drug therapy
Humans
Medicine
Medicine & Public Health
Neoplasms - drug therapy
Neurotoxicity
Oncology
Pharmacology/Toxicology
Quality of Life
Review Article
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Title Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain
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