Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike

• Published in: Nature (London) Vol. 624; no. 7992; pp. 639 - 644
• Main Authors: Wang, Qian, Guo, Yicheng, Liu, Liyuan, Schwanz, Logan T., Li, Zhiteng, Nair, Manoj S., Ho, Jerren, Zhang, Richard M., Iketani, Sho, Yu, Jian, Huang, Yiming, Qu, Yiming, Valdez, Riccardo, Lauring, Adam S., Huang, Yaoxing, Gordon, Aubree, Wang, Harris H., Liu, Lihong, Ho, David D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.12.2023; Nature Publishing Group
• Subjects: 101/1; 13/1; 13/109; 38/70; 631/250/2161; 631/250/255/2514; 631/326/596/2553; 631/326/596/2554; 631/326/596/2558; 82/1; 82/103; 82/80; 82/83; Affinity; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Antigenicity; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; COVID-19 Vaccines - immunology; Epitopes; Epitopes, B-Lymphocyte - immunology; Humanities and Social Sciences; Humans; Immune Sera - immunology; Immunization; Immunogenicity, Vaccine; Monoclonal antibodies; multidisciplinary; Mutation; Receptors; Receptors, Virus - metabolism; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; SARS-CoV-2 - metabolism; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; Vaccines; Viral diseases; Viruses

A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.2.86, has emerged and spread to numerous countries worldwide, raising alarm because its spike protein contains 34 additional mutations compared with its BA.2 predecessor 1 . We examined its antigenicity using human...