Ascorbate-and iron-driven redox activity of Dp44mT and Emodin facilitates peroxidation of micelles and bicelles

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 4; p. 130078
• Main Authors: Selyutina, O.Yu, Kononova, P.A., Koshman, V.E., Shelepova, E.A., Azad, M. Gholam, Afroz, R., Dharmasivam, M., Bernhardt, Paul V., Polyakov, N.E., Richardson, D.R.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2022
• Subjects: antioxidant activity; Ascorbate; Ascorbic Acid - chemistry; cell membranes; Dp44mT; drug therapy; electron paramagnetic resonance spectroscopy; emodin; Emodin - pharmacology; Ferrous Compounds; Hydrogen Peroxide; Iron; Iron - metabolism; Iron chelators; Ligands; lipid peroxidation; melanoma; Micelles; Oxidation-Reduction; oxidative stress; Reactive Oxygen Species; Thiosemicarbazones - pharmacology; Iron chelators; Iron; Ascorbate; Dp44mT

Iron (Fe)-induced oxidative stress leads to reactive oxygen species that damage biomembranes, with this mechanism being involved in the activity of some anti-cancer chemotherapeutics. Herein, we compared the effect of the ligand, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT), or the p...