Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase - Koike, Tatsuki; Constantinescu, Cristian C.; Ikeda, Shuhei; Nishi, Toshiya; Sunahara, Eiji; Miyamoto, Maki; Cole, Patricia; Barret, Olivier; Alagille, David; Papin, Caroline; Morley, Thomas; Fowles, Krista; et al. (European journal of nuclear medicine and molecular imaging, 2022)
Keywords: Animals; Autoradiography; Brain; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Cerebellum; Cholesterol; Cholesterol 24-Hydroxylase - metabolism; Enzymes; Epilepsy; Fluorine isotopes; Homeostasis; Humans; Hydroxylase; Imaging; In vitro methods and tests; In vivo methods and tests; Macaca mulatta - metabolism; Medicine; Medicine & Public Health; Mice; Neostriatum; Neuroimaging; Nuclear Medicine; Occupancy; Oncology; Original; Original Article; Orthopedics; Piperidines; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Pyridines; Radiology; Seizures; Tomography; CH24H; Soticlestat; [; Cholesterol 24-hydroxylase; F; PET; 18F