Isotretinoin Use and the Risk of Inflammatory Bowel Disease: A Case–Control Study

• Published in: The American journal of gastroenterology Vol. 105; no. 9; pp. 1986 - 1993
• Main Authors: Crockett, Seth D, Porter, Carol Q, Martin, Christopher F, Sandler, Robert S, Kappelman, Michael D
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.09.2010; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Acne Vulgaris - drug therapy; Adolescent; Adult; Biological and medical sciences; Case-Control Studies; Child; Dermatologic Agents - adverse effects; Dermatologic Agents - therapeutic use; Dose-Response Relationship, Drug; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - chemically induced; Isotretinoin - adverse effects; Isotretinoin - therapeutic use; Logistic Models; Male; Medical sciences; Middle Aged; Odds Ratio; Other diseases. Semiology; Risk; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Inflammatory bowel disease; Crohn disease; Retinoid; Risk factor; Gastroenterology; Digestive diseases; Intestinal disease; Antiacneic agent; Isotretinoin; Case control study; Inflammatory disease; Ulcerative colitis

Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven. We performed a case-control study using a large insurance claims database. Incident cases of IBD w...