Reduced γ-Aminobutyric Acid in Occipital and Anterior Cingulate Cortices in Primary Insomnia: a Link to Major Depressive Disorder?

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 37; no. 6; pp. 1548 - 1557
• Main Authors: Plante, David T, Jensen, J Eric, Schoerning, Laura, Winkelman, John W
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.05.2012
• Subjects: Actigraphy; Adult; Adult and adolescent clinical studies; Biological and medical sciences; Brain; Brain Mapping; Case-Control Studies; Cortex (cingulate); Cortex (occipital); Creatine; Creatine - metabolism; Data processing; Depression; Depressive Disorder, Major - complications; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Female; gamma -Aminobutyric acid; gamma-Aminobutyric Acid - metabolism; Gyrus Cinguli - diagnostic imaging; Gyrus Cinguli - metabolism; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Medical sciences; Middle Aged; Mood; Mood disorders; Nervous system; Nervous system (semeiology, syndromes); Neurology; Occipital Lobe - diagnostic imaging; Occipital Lobe - metabolism; Original; Protons; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radionuclide Imaging; Retrospective Studies; Sleep disorders; Sleep Initiation and Maintenance Disorders - complications; Sleep Initiation and Maintenance Disorders - diagnostic imaging; Sleep Initiation and Maintenance Disorders - pathology; Spectroscopy; Thalamus; Young Adult; Mood disorder; Nervous system diseases; sleep disorders; Central nervous system; Sleep disorder; Depression; magnetic resonance spectroscopy; Encephalon; Cingulate cortex; Insomnia; Occipital cortex; Neurotransmitter; GABA; Neurological disorder; anterior cingulate cortex
• ISSN: 0893-133X; 1740-634X; 1740-634X
• DOI: 10.1038/npp.2012.4

Insomnia is closely related to major depressive disorder (MDD) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine our understanding of the neurobiology of both sleep and mood disorders. Clinical and basic science data suggest a role for reduced γ-aminobu...