Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron

• Published in: Nature (London) Vol. 602; no. 7898; pp. 682 - 688
• Main Authors: Carreño, Juan Manuel, Alshammary, Hala, Tcheou, Johnstone, Singh, Gagandeep, Raskin, Ariel J., Kawabata, Hisaaki, Sominsky, Levy A., Clark, Jordan J., Adelsberg, Daniel C., Bielak, Dominika A., Gonzalez-Reiche, Ana Silvia, Dambrauskas, Nicholas, Vigdorovich, Vladimir, Srivastava, Komal, Sather, D. Noah, Sordillo, Emilia Mia, Bajic, Goran, van Bakel, Harm, Simon, Viviana, Krammer, Florian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.02.2022; Nature Publishing Group
• Subjects: 2019-nCoV Vaccine mRNA-1273 - immunology; 631/250/590/2293; 631/326/596/4130; 82; 82/1; 82/80; Adult; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Binding; BNT162 Vaccine - administration & dosage; BNT162 Vaccine - immunology; Convalescence; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - transmission; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - immunology; Disease transmission; Female; Humanities and Social Sciences; Humans; Immune Evasion - immunology; Immune Sera - immunology; Immunization, Secondary; Infections; Metropolitan areas; Models, Molecular; mRNA; mRNA vaccines; multidisciplinary; Mutation; Neutralization Tests; Neutralizing; Pandemics; Proteins; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Vaccination; Vaccine efficacy; Vaccines; Viral diseases; Viruses; South Africa; Botswana

The Omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially identified in November 2021 in South Africa and Botswana, as well as in a sample from a traveller from South Africa in Hong Kong 1 , 2 . Since then, Omicron has been detected globally. This...