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Keywords: 2019-nCoV Vaccine mRNA-1273 - immunology; 631/250/590/2293; 631/326/596/4130; 82; 82/1; 82/80; Adult; Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; Binding; BNT162 Vaccine - administration & dosage; BNT162 Vaccine - immunology; Convalescence; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - transmission; COVID-19 - virology; COVID-19 vaccines; COVID-19 Vaccines - immunology; Disease transmission; Female; Humanities and Social Sciences; Humans; Immune Evasion - immunology; Immune Sera - immunology; Immunization, Secondary; Infections; Metropolitan areas; Models, Molecular; mRNA; mRNA vaccines; multidisciplinary; Mutation; Neutralization Tests; Neutralizing; Pandemics; Proteins; SARS-CoV-2 - classification; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; Spike protein; Vaccination; Vaccine efficacy; Vaccines; Viral diseases; Viruses; South Africa; Botswana