Safety, pharmacokinetic and pharmacodynamic properties of single ascending dose and continuous infusion of remimazolam besylate in healthy Chinese volunteers

• Published in: European journal of clinical pharmacology Vol. 76; no. 3; pp. 383 - 391
• Main Authors: Sheng, Xiao-yan, Liang, Yan, Yang, Xue-yuan, Li, Li-e, Ye, Xia, Zhao, Xia, Cui, Yi-min
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2020; Springer Nature B.V
• Subjects: Anesthesia; Biomedical and Life Sciences; Biomedicine; Clinical Trial; Clinical trials; Dosage; Midazolam; Pharmacodynamics; Pharmacokinetics; Pharmacology/Toxicology; Remimazolam besylate; Pharmacodynamics; Pharmacokinetics; Chinese subjects

Purpose The aim of the present study was to evaluate the safety, pharmacokinetic (PK) and pharmacodynamic (PD) properties of remimazolam besylate following single ascending dose (SAD) and continuous infusion in healthy Chinese volunteers. Methods This was a randomized phase I study conducted in two...