Regulation of FGF23 production and phosphate metabolism by bone–kidney interactions

• Published in: Nature reviews. Nephrology Vol. 19; no. 3; pp. 185 - 193
• Main Authors: Agoro, Rafiou, White, Kenneth E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2023; Nature Publishing Group
• Subjects: 631/443/272/1684; 631/443/63; 631/443/810; Anemia; Biological activity; Bone and Bones - metabolism; Fibroblast Growth Factor-23 - metabolism; Fibroblast Growth Factors - metabolism; Fibroblasts; Glycerol; Growth factors; Homeostasis; Humans; Kidney - metabolism; Kidney diseases; Kinases; Klotho Proteins; Medicine; Medicine & Public Health; Metabolism; Metabolites; Mutation; Nephrology; Peptides; Phosphates - metabolism; Proteins; Review Article; Vitamin D

The bone-derived hormone fibroblast growth factor 23 (FGF23) functions in concert with parathyroid hormone (PTH) and the active vitamin D metabolite, 1,25(OH) 2 vitamin D (1,25D), to control phosphate and calcium homeostasis. A rise in circulating levels of phosphate and 1,25D leads to FGF23 product...