Molecular and cellular regulation of human glucokinase

• Published in: Archives of biochemistry and biophysics Vol. 663; pp. 199 - 213
• Main Authors: Sternisha, Shawn M., Miller, Brian G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.03.2019
• Subjects: Animals; Carrier Proteins - physiology; catalytic activity; Conformational dynamics; Diabetes; Enzyme Activation; enzyme activity; genes; Glucokinase; Glucokinase - antagonists & inhibitors; Glucokinase - chemistry; Glucokinase - metabolism; glucose; Glucose - analysis; glycogen; homeostasis; Humans; hyperinsulinemia; insulin secretion; liver; mutation; pancreas; patients; pharmaceutical industry; Phosphofructokinase-2 - metabolism; post-translational modification; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Protein-protein interaction; protein-protein interactions; Regulation; SUMO-1 Protein - metabolism; Regulation; Diabetes; Protein-protein interaction; Glucokinase; Conformational dynamics

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK). GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of insulin secretion, and in the liver, where it participates in glycogen synthesis. A multitude of disease-causing mutati...