Effect of Aldose Reductase Inhibition on Cardiovascular Reflex Tests in Patients with Definite Diabetic Autonomic Neuropathy Over a Period of 2 Years

• Published in: Journal of diabetes and its complications Vol. 12; no. 4; pp. 201 - 207
• Main Authors: Didangelos, Triantaffilos P., Karamitsos, Dimitrios T., Athyros, Vasilios G., Kourtoglou, Georgios I.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.1998; Elsevier Science
• Subjects: Adult; Aldehyde Reductase - antagonists & inhibitors; Autonomic Nervous System - physiopathology; Biological and medical sciences; Cardiovascular System - physiopathology; Diabetic Neuropathies - drug therapy; Diabetic Neuropathies - epidemiology; Diabetic Neuropathies - physiopathology; Enzyme Inhibitors - therapeutic use; Female; Hormones. Endocrine system; Humans; Male; Medical sciences; Middle Aged; Naphthalenes - therapeutic use; Pharmacology. Drug treatments; Prospective Studies; Reflex; Greece; Europe; Endocrinopathy; Human; Immunopathology; Nervous system diseases; Enzyme; Treatment efficiency; Enzyme inhibitor; Autoimmune disease; Non insulin dependent diabetes; Long term; Heart rate; Chemotherapy; Valsalva maneuver; Treatment; Diseases of the autonomic nervous system; Aldehyde reductase; Insulin dependent diabetes; Adult; Complication; Oxidoreductases; Postural fitting; Tolrestat; Comparative study

The potential of the aldose reductase inhibitor tolrestat to ameliorate definite diabetic autonomic neuropathy (DAN), as defined by standard cardiovascular autonomic function tests, was evaluated in 35 patients over a period of 2 years, with repeated measurements at 3-month intervals. The effect of...