Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation - Ruzza, Paolo; Vitale, Rosa Maria; Hussain, Rohanah; Biondi, Barbara; Amodeo, Pietro; Sechi, GianPietro; Siligardi, Giuliano (Biochimica et biophysica acta, 2016)
Keywords: Alexander Disease - drug therapy; Alexander Disease - metabolism; Alexander Disease - pathology; alpha-Synuclein - biosynthesis; alpha-Synuclein - chemistry; alpha-Synuclein - metabolism; Alzheimer disease; Animals; astrocytes; Astrocytes - drug effects; Astrocytes - metabolism; Astrocytes - pathology; binding sites; Binding Sites - drug effects; blood-brain barrier; Ceftriaxone; Ceftriaxone - administration & dosage; Ceftriaxone - chemistry; circular dichroism spectroscopy; Glial fibrillary acidic protein; Glial Fibrillary Acidic Protein - chemistry; Glial Fibrillary Acidic Protein - genetics; Glial Fibrillary Acidic Protein - metabolism; Humans; Intermediate Filament Proteins - chemistry; Intermediate Filament Proteins - metabolism; ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; molecular models; Nerve Degeneration - drug therapy; Nerve Degeneration - pathology; Neurodegenerative diseases; patients; PC12 Cells; phenytoin; Phenytoin - administration & dosage; Phenytoin - chemistry; polymerization; protective effect; Protein Aggregation, Pathological - drug therapy; Protein Aggregation, Pathological - metabolism; Rats; scrapie; sodium; Synchrotron radiation circular dichroism spectroscopy; toxicity; Synchrotron radiation circular dichroism spectroscopy; Ceftriaxone; Neurodegenerative diseases; Glial fibrillary acidic protein