Histone deacetyltransferase inhibitors Trichostatin A and Mocetinostat differentially regulate MMP9, IL-18 and RECK expression, and attenuate Angiotensin II-induced cardiac fibroblast migration and proliferation

• Published in: Hypertension research Vol. 39; no. 10; pp. 709 - 716
• Main Authors: Somanna, Naveen K, Valente, Anthony J, Krenz, Maike, McDonald, Kerry S, Higashi, Yusuke, Noda, Makoto, Chandrasekar, Bysani
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2016
• Subjects: Angiotensin II - pharmacology; Animals; Benzamides - pharmacology; Cell Death - drug effects; Cell Movement - drug effects; Cell Proliferation - drug effects; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; GPI-Linked Proteins - metabolism; Heart - drug effects; Histone Deacetylase Inhibitors - pharmacology; Hydroxamic Acids - pharmacology; Interleukin-18 - metabolism; Matrix Metalloproteinase 9 - metabolism; Mice; Myocardium - cytology; Myocardium - metabolism; Pyrimidines - pharmacology

Histone acetylation/deacetylation plays a key role in the epigenetic regulation of multiple pro-fibrotic genes. Here we investigated the effects of histone deacetyltransferase (HDAC) inhibition on angiotensin (Ang)-II-induced pro-fibrotic changes in adult mouse cardiac fibroblasts (CF). CF express c...