Genotoxic effects in oral mucosal cells caused by the use of orthodontic fixed appliances in patients after short and long periods of treatment

Objective This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does...

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Published inClinical oral investigations Vol. 23; no. 7; pp. 2913 - 2919
Main Authors Flores-Bracho, María Gabriela, Takahashi, Catarina Satie, Castillo, Willian Orlando, Saraiva, Maria Conceição Pereira, Küchler, Erika Calvano, Matsumoto, Mírian Aiko Nakane, Ferreira, José Tarcísio Lima, Nelson-Filho, Paulo, Romano, Fabio Lourenço
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2019
Springer Nature B.V
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Abstract Objective This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does not cause genotoxic effects in patients. Material and methods An observational cross-sectional study including 74 patients enrolled in corrective orthodontic treatment and 21 control patients, between 11 and 35 years of age, of both genders, participated in the research. Patients undergoing treatment were divided into four treatment groups differentiated by treatment periods: G1, n  = 21 (1 month to 12 months); G2, n  = 21 (13 to 24 months); G3, n  = 23 (25 to 48 months); and G4, n  = 9 (over 48 months). Cells were collected by scraping the internal side of the cheek and subsequently placed in tubes containing 0.9% sodium chloride solution. The sample underwent evaluation for genotoxic effects by means of the micronucleus test (MNT). Bivariate analyses were performed using parametric tests ( t test or ANOVA) and nonparametric tests (Chi-square test, Kruskal-Wallis test, Dunn post-test). The adopted level of significance was 5%. Results Statistically significant differences for any of the genotoxic abnormalities (binucleated, trinucleated, karyolysis, piknosis, nuclear buds) were not found except for karyolysis, which was higher in the control group than in G4 ( p  < 0.05). Conclusions This study did not demonstrate evidence of genotoxic effects even after long periods of corrective orthodontic treatment. Clinical relevance This study explores genotoxic effects in fixed orthodontic patients.
AbstractList ObjectiveThis study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does not cause genotoxic effects in patients.Material and methodsAn observational cross-sectional study including 74 patients enrolled in corrective orthodontic treatment and 21 control patients, between 11 and 35 years of age, of both genders, participated in the research. Patients undergoing treatment were divided into four treatment groups differentiated by treatment periods: G1, n = 21 (1 month to 12 months); G2, n = 21 (13 to 24 months); G3, n = 23 (25 to 48 months); and G4, n = 9 (over 48 months). Cells were collected by scraping the internal side of the cheek and subsequently placed in tubes containing 0.9% sodium chloride solution. The sample underwent evaluation for genotoxic effects by means of the micronucleus test (MNT). Bivariate analyses were performed using parametric tests (t test or ANOVA) and nonparametric tests (Chi-square test, Kruskal-Wallis test, Dunn post-test). The adopted level of significance was 5%.ResultsStatistically significant differences for any of the genotoxic abnormalities (binucleated, trinucleated, karyolysis, piknosis, nuclear buds) were not found except for karyolysis, which was higher in the control group than in G4 (p < 0.05).ConclusionsThis study did not demonstrate evidence of genotoxic effects even after long periods of corrective orthodontic treatment.Clinical relevanceThis study explores genotoxic effects in fixed orthodontic patients.
This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does not cause genotoxic effects in patients. An observational cross-sectional study including 74 patients enrolled in corrective orthodontic treatment and 21 control patients, between 11 and 35 years of age, of both genders, participated in the research. Patients undergoing treatment were divided into four treatment groups differentiated by treatment periods: G1, n = 21 (1 month to 12 months); G2, n = 21 (13 to 24 months); G3, n = 23 (25 to 48 months); and G4, n = 9 (over 48 months). Cells were collected by scraping the internal side of the cheek and subsequently placed in tubes containing 0.9% sodium chloride solution. The sample underwent evaluation for genotoxic effects by means of the micronucleus test (MNT). Bivariate analyses were performed using parametric tests (t test or ANOVA) and nonparametric tests (Chi-square test, Kruskal-Wallis test, Dunn post-test). The adopted level of significance was 5%. Statistically significant differences for any of the genotoxic abnormalities (binucleated, trinucleated, karyolysis, piknosis, nuclear buds) were not found except for karyolysis, which was higher in the control group than in G4 (p < 0.05). This study did not demonstrate evidence of genotoxic effects even after long periods of corrective orthodontic treatment. This study explores genotoxic effects in fixed orthodontic patients.
Objective This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a control group without treatment. The null hypothesis to be tested is that corrective orthodontic treatment at different periods does not cause genotoxic effects in patients. Material and methods An observational cross-sectional study including 74 patients enrolled in corrective orthodontic treatment and 21 control patients, between 11 and 35 years of age, of both genders, participated in the research. Patients undergoing treatment were divided into four treatment groups differentiated by treatment periods: G1, n  = 21 (1 month to 12 months); G2, n  = 21 (13 to 24 months); G3, n  = 23 (25 to 48 months); and G4, n  = 9 (over 48 months). Cells were collected by scraping the internal side of the cheek and subsequently placed in tubes containing 0.9% sodium chloride solution. The sample underwent evaluation for genotoxic effects by means of the micronucleus test (MNT). Bivariate analyses were performed using parametric tests ( t test or ANOVA) and nonparametric tests (Chi-square test, Kruskal-Wallis test, Dunn post-test). The adopted level of significance was 5%. Results Statistically significant differences for any of the genotoxic abnormalities (binucleated, trinucleated, karyolysis, piknosis, nuclear buds) were not found except for karyolysis, which was higher in the control group than in G4 ( p  < 0.05). Conclusions This study did not demonstrate evidence of genotoxic effects even after long periods of corrective orthodontic treatment. Clinical relevance This study explores genotoxic effects in fixed orthodontic patients.
Author Küchler, Erika Calvano
Romano, Fabio Lourenço
Flores-Bracho, María Gabriela
Saraiva, Maria Conceição Pereira
Matsumoto, Mírian Aiko Nakane
Ferreira, José Tarcísio Lima
Nelson-Filho, Paulo
Takahashi, Catarina Satie
Castillo, Willian Orlando
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  givenname: Willian Orlando
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Cites_doi 10.1093/mutage/gel056
10.1093/mutage/geq051
10.1111/jopr.12100
10.4321/S1137-66272005000300007
10.4238/vol7-4gmr508
10.1016/0165-1161(92)90033-I
10.1016/0165-7992(91)90008-R
10.1016/j.ajodo.2010.07.027
10.1093/mutage/geu023
10.1002/ijc.2910500506
10.1158/1055-9965.EPI-06-0248
10.1093/mutage/gem029
10.1016/S1383-5742(00)00049-1
10.1038/nprot.2007.77
10.1016/j.mrgentox.2003.10.002
10.1093/carcin/bgl177
10.1016/j.mrrev.2011.06.005
10.1016/j.mrrev.2008.03.007
10.1038/nprot.2009.53
10.1016/S0022-3913(00)80016-5
10.1016/S0140-6736(07)61602-X
10.1016/S1383-5718(01)00279-0
10.1016/0165-1161(94)90007-8
10.1007/s00056-008-0808-4
10.1016/0027-5107(93)90049-L
10.4041/kjod.2014.44.3.128
10.1016/j.etap.2015.05.007
10.1016/S1383-5718(00)00063-2
10.1016/j.ajodo.2007.03.021
10.1016/j.ajodo.2010.05.025
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Keywords Genetic
Orthodontic appliances
Test of micronucleus
Cytogenetic
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Springer Nature B.V
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References Petoumeno, Kislyuk, Hoederath, Keilig, Bourauel, Jäger (CR4) 2008; 69
Toy, Ozturk, Karatas, Yalcin (CR6) 2014; 44
Natarajan, Padmanabhan, Chitharanjan, Narasimhan (CR29) 2011; 140
Ristic, Vucevic, Radovic, Djordjevic, Nikacevic, Colic (CR3) 2014; 23
Zalacain, Sierrasesúmaga, Patiño (CR8) 2005; 28
Fenech (CR36) 2007; 2
Nersesyan, Kundi, Atefie, Schulte-Hermann, Knasmüller (CR11) 2006; 15
Xue, Wang, Ma, Zhou, Wu, Zhang, Xu, Chen, Wang (CR16) 1992; 50
Titenko-Holland, Moore, Smith (CR33) 1994; 312
Thomas, Holland, Bolognesi, Kirsch-Volders, Bonassi, Zeiger, Knasmueller, Fenech (CR10) 2009; 4
Martín-Cameán, Jos, Mellano-García, Iglesias-Linares, Solano, Cameán (CR31) 2015; 40
Holland, Bolognesi, Kirsch-Volders, Bonassi, Zeiger, Knasmueller, Fenech (CR13) 2008; 659
Fenech (CR17) 1993; 285
Heravi, Abbaszadegan, Merati, Hasanzadeh, Dadkhah, Ahrari (CR30) 2013; 10
Fenech, Bolognesi, Kirsch-Volders, Bonassi, Zeiger, Knasmüller, Holland (CR9) 2007; 22
Bonassi, Znaor, Ceppi, Lando, Chang, Holland (CR21) 2007; 28
Konopacka (CR23) 2003; 50
Bloching, Reich, Schubert, Grummt, Sandner (CR22) 2008; 44
Westphalen, Menezes, Prá, Garcia, Schmitt, Henriques, Medina-Silva (CR27) 2008; 7
Bukvic, Gentile, Susca, Fanelli, Serio, Buonadonna, Capurso, Guanti (CR19) 2001; 498
von Elm, Altman, Egger, Pocock, Gøtzsche, Vandenbroucke (CR32) 2007; 370
Lee, Allison, O'Brien, Khazanie, Johnke, Brown (CR20) 2004; 557
Wataha (CR1) 2000; 83
Katarkar, Mukherjee, Khan, Ray, Chaudhuri (CR26) 2014; 29
Migliore, Guidotti, Favre, Nardi, Sessa, Brunori (CR15) 1991; 263
Fenech, Holland, Zeiger, Chang, Burgaz, Thomas, Bolognesi, Knasmueller, Kirsch-Volders, Bonassi (CR25) 2011; 26
Thomas, Hecker, Faunt, Fenech (CR35) 2007; 22
Saran, Tiwari, Reddy, Ahuja (CR12) 2008; 44
Ramirez, Saldanha (CR34) 2002; 1
Tolbert, Shy, Allen (CR7) 1992; 271
Bonassi, Coskun, Ceppi, Lando, Bolognesi, Burgaz (CR24) 2011; 728
Hafez, Selim, Kamel Eid, Tawfik, Al-Ashkar, Mostafa (CR28) 2011; 140
Albertini, Anderson, Douglas, Hagmar, Hemminki, Merlo (CR5) 2000; 463
House, Sernetz, Dymock, Sandy, Ireland (CR2) 2008; 133
Martino-Roth, Viégas, Roth (CR14) 2003; 2
Landi, Lazzolino, Barale (CR18) 2000; 469
R Saran (2795_CR12) 2008; 44
M Bloching (2795_CR22) 2008; 44
M Fenech (2795_CR17) 1993; 285
TK Lee (2795_CR20) 2004; 557
PE Tolbert (2795_CR7) 1992; 271
M Fenech (2795_CR25) 2011; 26
E Petoumeno (2795_CR4) 2008; 69
N Titenko-Holland (2795_CR33) 1994; 312
L Ristic (2795_CR3) 2014; 23
S Landi (2795_CR18) 2000; 469
M Zalacain (2795_CR8) 2005; 28
P Thomas (2795_CR10) 2009; 4
A Nersesyan (2795_CR11) 2006; 15
F Heravi (2795_CR30) 2013; 10
A Katarkar (2795_CR26) 2014; 29
M Fenech (2795_CR9) 2007; 22
A Martín-Cameán (2795_CR31) 2015; 40
P Thomas (2795_CR35) 2007; 22
MG Martino-Roth (2795_CR14) 2003; 2
E von Elm (2795_CR32) 2007; 370
M Fenech (2795_CR36) 2007; 2
RJ Albertini (2795_CR5) 2000; 463
S Bonassi (2795_CR24) 2011; 728
KX Xue (2795_CR16) 1992; 50
HS Hafez (2795_CR28) 2011; 140
A Ramirez (2795_CR34) 2002; 1
N Bukvic (2795_CR19) 2001; 498
S Bonassi (2795_CR21) 2007; 28
L Migliore (2795_CR15) 1991; 263
M Konopacka (2795_CR23) 2003; 50
GH Westphalen (2795_CR27) 2008; 7
K House (2795_CR2) 2008; 133
JC Wataha (2795_CR1) 2000; 83
M Natarajan (2795_CR29) 2011; 140
E Toy (2795_CR6) 2014; 44
N Holland (2795_CR13) 2008; 659
References_xml – volume: 22
  start-page: 3
  year: 2007
  end-page: 4
  ident: CR9
  article-title: Harmonisation of the micronucleus assay in human buccal cells--a human micronucleus (HUMN) project (www.humn.org) initiative commencing in 2007
  publication-title: Mutagenesis
  doi: 10.1093/mutage/gel056
  contributor:
    fullname: Holland
– volume: 26
  start-page: 239
  year: 2011
  end-page: 245
  ident: CR25
  article-title: The HUMN and HUMNxL international collaboration projects on human micronucleus assays in lymphocytes and buccal cells-past, present and future
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geq051
  contributor:
    fullname: Bonassi
– volume: 23
  start-page: 221
  year: 2014
  end-page: 226
  ident: CR3
  article-title: Corrosive and cytotoxic properties of compact specimens and microparticles of Ni-Cr dental alloy
  publication-title: J Prosthodont
  doi: 10.1111/jopr.12100
  contributor:
    fullname: Colic
– volume: 28
  start-page: 227
  year: 2005
  end-page: 236
  ident: CR8
  article-title: The cytogenetic assay as a measure of genetic instability induced by genotoxic agents
  publication-title: An Sist Sanit Navar
  doi: 10.4321/S1137-66272005000300007
  contributor:
    fullname: Patiño
– volume: 7
  start-page: 1259
  year: 2008
  end-page: 1266
  ident: CR27
  article-title: In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays
  publication-title: Genet Mol Res
  doi: 10.4238/vol7-4gmr508
  contributor:
    fullname: Medina-Silva
– volume: 271
  start-page: 69
  year: 1992
  end-page: 77
  ident: CR7
  article-title: Micronuclei and other nuclear anomalies in buccal smears: methods development
  publication-title: Mutat Res
  doi: 10.1016/0165-1161(92)90033-I
  contributor:
    fullname: Allen
– volume: 263
  start-page: 243
  year: 1991
  end-page: 248
  ident: CR15
  article-title: Micronuclei in lymphocytes of young patients under antileukemic therapy
  publication-title: Mutat Res
  doi: 10.1016/0165-7992(91)90008-R
  contributor:
    fullname: Brunori
– volume: 140
  start-page: 383
  year: 2011
  end-page: 388
  ident: CR29
  article-title: Evaluation of the genotoxic effects of fixed appliances on buccal mucosal cells and the relationship to nickel and chromium concentrations: an in-vivo study
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2010.07.027
  contributor:
    fullname: Narasimhan
– volume: 44
  start-page: 220
  year: 2008
  end-page: 226
  ident: CR22
  article-title: Micronucleus rate of buccal mucosal epithelial cells in relation to buccal hygiene and dental factors
  publication-title: Bucal Oncol
  contributor:
    fullname: Sandner
– volume: 29
  start-page: 325
  year: 2014
  end-page: 334
  ident: CR26
  article-title: Comparative evaluation of genotoxicity by micronucleus assay in the buccal mucosa over comet assay in peripheral blood in buccal precancer and cancer patients
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geu023
  contributor:
    fullname: Chaudhuri
– volume: 50
  start-page: 702
  year: 1992
  end-page: 705
  ident: CR16
  article-title: Micronucleus formation in peripheral-blood lymphocytes from smokers and the influence of alcohol- and tea-drinking habits
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910500506
  contributor:
    fullname: Wang
– volume: 15
  start-page: 1835
  year: 2006
  end-page: 1840
  ident: CR11
  article-title: Effect of staining procedures on the results of micronucleus assays with exfoliated buccal mucosa cells
  publication-title: Cancer Epidemiol Biomark Prev
  doi: 10.1158/1055-9965.EPI-06-0248
  contributor:
    fullname: Knasmüller
– volume: 50
  start-page: 380
  year: 2003
  end-page: 382
  ident: CR23
  article-title: Effect of smoking and aging on micronucleus frequencies in human exfoliated buccal cells
  publication-title: Neoplasma
  contributor:
    fullname: Konopacka
– volume: 22
  start-page: 371
  year: 2007
  end-page: 379
  ident: CR35
  article-title: Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease
  publication-title: Mutagenesis
  doi: 10.1093/mutage/gem029
  contributor:
    fullname: Fenech
– volume: 463
  start-page: 111
  year: 2000
  end-page: 172
  ident: CR5
  article-title: IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety
  publication-title: Mutat Res
  doi: 10.1016/S1383-5742(00)00049-1
  contributor:
    fullname: Merlo
– volume: 2
  start-page: 1084
  year: 2007
  end-page: 1104
  ident: CR36
  article-title: Cytokinesis-block micronucleus cytome assay
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2007.77
  contributor:
    fullname: Fenech
– volume: 44
  start-page: 354
  year: 2008
  end-page: 360
  ident: CR12
  article-title: Risk assessment of buccal cancer in patients with pre-cancerous states of the buccal cavity using micronucleus test and challenge assay
  publication-title: Buccal Oncol
  contributor:
    fullname: Ahuja
– volume: 2
  start-page: 410
  year: 2003
  end-page: 417
  ident: CR14
  article-title: Occupational genotoxicity risk evaluation through the comet assay and the micronucleus test
  publication-title: Genet Mol Res
  contributor:
    fullname: Roth
– volume: 557
  start-page: 75
  year: 2004
  end-page: 84
  ident: CR20
  article-title: Ginseng reduces the micronuclei yield in lymphocytes after irradiation
  publication-title: Mutat Res
  doi: 10.1016/j.mrgentox.2003.10.002
  contributor:
    fullname: Brown
– volume: 28
  start-page: 625
  year: 2007
  end-page: 631
  ident: CR21
  article-title: An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgl177
  contributor:
    fullname: Holland
– volume: 728
  start-page: 88
  year: 2011
  end-page: 97
  ident: CR24
  article-title: The human MicroNucleus project on exfoliated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol
  publication-title: Mutat Res
  doi: 10.1016/j.mrrev.2011.06.005
  contributor:
    fullname: Burgaz
– volume: 659
  start-page: 93
  year: 2008
  end-page: 108
  ident: CR13
  article-title: The micronucleus assay in human buccal cells as a tool for biomonitoring DNA damage: the HUMN project perspective on current status and knowledge gaps
  publication-title: Mutat Res
  doi: 10.1016/j.mrrev.2008.03.007
  contributor:
    fullname: Fenech
– volume: 4
  start-page: 825
  year: 2009
  end-page: 837
  ident: CR10
  article-title: Buccal micronucleus cytome assay
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2009.53
  contributor:
    fullname: Fenech
– volume: 83
  start-page: 223
  year: 2000
  end-page: 234
  ident: CR1
  article-title: Biocompatibility of dental casting alloys: a review
  publication-title: J Prosthet Dent
  doi: 10.1016/S0022-3913(00)80016-5
  contributor:
    fullname: Wataha
– volume: 10
  start-page: 494
  year: 2013
  end-page: 500
  ident: CR30
  article-title: DNA damage in buccal mucosa cells of patients with fixed orthodontic appliances
  publication-title: J Dent
  contributor:
    fullname: Ahrari
– volume: 370
  start-page: 1453
  issue: 9596
  year: 2007
  end-page: 1457
  ident: CR32
  article-title: The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)61602-X
  contributor:
    fullname: Vandenbroucke
– volume: 498
  start-page: 159
  year: 2001
  end-page: 167
  ident: CR19
  article-title: Sex chromosome loss, micronuclei, sister chromatid exchange and aging: a study including 16 centenarians
  publication-title: Mutat Res
  doi: 10.1016/S1383-5718(01)00279-0
  contributor:
    fullname: Guanti
– volume: 312
  start-page: 39
  year: 1994
  end-page: 50
  ident: CR33
  article-title: Measurement and characterization of micronuclei in exfoliated human cells by fluorescence in situ hybridization with a centromeric probe
  publication-title: Mutat Res
  doi: 10.1016/0165-1161(94)90007-8
  contributor:
    fullname: Smith
– volume: 69
  start-page: 411
  year: 2008
  end-page: 423
  ident: CR4
  article-title: Corrosion susceptibility and nickel release of nickel titanium wires during clinical application
  publication-title: J Orofac Orthop
  doi: 10.1007/s00056-008-0808-4
  contributor:
    fullname: Jäger
– volume: 285
  start-page: 35
  year: 1993
  end-page: 44
  ident: CR17
  article-title: The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations
  publication-title: Mutat Res
  doi: 10.1016/0027-5107(93)90049-L
  contributor:
    fullname: Fenech
– volume: 44
  start-page: 128
  year: 2014
  end-page: 135
  ident: CR6
  article-title: Evaluation of the genotoxicity and cytotoxicity in the buccal epithelial cells of patients undergoing orthodontic treatment with three light-cured bonding composites by using micronucleus testing
  publication-title: Korean J Orthod
  doi: 10.4041/kjod.2014.44.3.128
  contributor:
    fullname: Yalcin
– volume: 40
  start-page: 86
  year: 2015
  end-page: 113
  ident: CR31
  article-title: In vitro and in vivo evidence of cytotoxic and genotoxic effects of metal ions released by orthodontic appliances: a review
  publication-title: Environ Toxicol Pharmacol
  doi: 10.1016/j.etap.2015.05.007
  contributor:
    fullname: Cameán
– volume: 469
  start-page: 159
  year: 2000
  end-page: 166
  ident: CR18
  article-title: Are baseline frequencies of SCEs, CAs, and MN in human lymphocytes related to hematological values?
  publication-title: Mutat Res
  doi: 10.1016/S1383-5718(00)00063-2
  contributor:
    fullname: Barale
– volume: 1
  start-page: 246
  year: 2002
  end-page: 260
  ident: CR34
  article-title: Micronucleus investigation of alcoholic patients with buccal carcinomas
  publication-title: Genet Mol Res
  contributor:
    fullname: Saldanha
– volume: 133
  start-page: 584
  year: 2008
  end-page: 592
  ident: CR2
  article-title: Corrosion of orthodontic appliances--should we care?
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2007.03.021
  contributor:
    fullname: Ireland
– volume: 140
  start-page: 298
  year: 2011
  end-page: 308
  ident: CR28
  article-title: Cytotoxicity, genotoxicity, and metal release in patients with fixed orthodontic appliances: a longitudinal in-vivo study
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2010.05.025
  contributor:
    fullname: Mostafa
– volume: 15
  start-page: 1835
  year: 2006
  ident: 2795_CR11
  publication-title: Cancer Epidemiol Biomark Prev
  doi: 10.1158/1055-9965.EPI-06-0248
  contributor:
    fullname: A Nersesyan
– volume: 1
  start-page: 246
  year: 2002
  ident: 2795_CR34
  publication-title: Genet Mol Res
  contributor:
    fullname: A Ramirez
– volume: 263
  start-page: 243
  year: 1991
  ident: 2795_CR15
  publication-title: Mutat Res
  doi: 10.1016/0165-7992(91)90008-R
  contributor:
    fullname: L Migliore
– volume: 498
  start-page: 159
  year: 2001
  ident: 2795_CR19
  publication-title: Mutat Res
  doi: 10.1016/S1383-5718(01)00279-0
  contributor:
    fullname: N Bukvic
– volume: 469
  start-page: 159
  year: 2000
  ident: 2795_CR18
  publication-title: Mutat Res
  doi: 10.1016/S1383-5718(00)00063-2
  contributor:
    fullname: S Landi
– volume: 26
  start-page: 239
  year: 2011
  ident: 2795_CR25
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geq051
  contributor:
    fullname: M Fenech
– volume: 50
  start-page: 702
  year: 1992
  ident: 2795_CR16
  publication-title: Int J Cancer
  doi: 10.1002/ijc.2910500506
  contributor:
    fullname: KX Xue
– volume: 44
  start-page: 128
  year: 2014
  ident: 2795_CR6
  publication-title: Korean J Orthod
  doi: 10.4041/kjod.2014.44.3.128
  contributor:
    fullname: E Toy
– volume: 557
  start-page: 75
  year: 2004
  ident: 2795_CR20
  publication-title: Mutat Res
  doi: 10.1016/j.mrgentox.2003.10.002
  contributor:
    fullname: TK Lee
– volume: 133
  start-page: 584
  year: 2008
  ident: 2795_CR2
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2007.03.021
  contributor:
    fullname: K House
– volume: 28
  start-page: 625
  year: 2007
  ident: 2795_CR21
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgl177
  contributor:
    fullname: S Bonassi
– volume: 140
  start-page: 298
  year: 2011
  ident: 2795_CR28
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2010.05.025
  contributor:
    fullname: HS Hafez
– volume: 7
  start-page: 1259
  year: 2008
  ident: 2795_CR27
  publication-title: Genet Mol Res
  doi: 10.4238/vol7-4gmr508
  contributor:
    fullname: GH Westphalen
– volume: 44
  start-page: 354
  year: 2008
  ident: 2795_CR12
  publication-title: Buccal Oncol
  contributor:
    fullname: R Saran
– volume: 285
  start-page: 35
  year: 1993
  ident: 2795_CR17
  publication-title: Mutat Res
  doi: 10.1016/0027-5107(93)90049-L
  contributor:
    fullname: M Fenech
– volume: 728
  start-page: 88
  year: 2011
  ident: 2795_CR24
  publication-title: Mutat Res
  doi: 10.1016/j.mrrev.2011.06.005
  contributor:
    fullname: S Bonassi
– volume: 2
  start-page: 1084
  year: 2007
  ident: 2795_CR36
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2007.77
  contributor:
    fullname: M Fenech
– volume: 140
  start-page: 383
  year: 2011
  ident: 2795_CR29
  publication-title: Am J Orthod Dentofac Orthop
  doi: 10.1016/j.ajodo.2010.07.027
  contributor:
    fullname: M Natarajan
– volume: 271
  start-page: 69
  year: 1992
  ident: 2795_CR7
  publication-title: Mutat Res
  doi: 10.1016/0165-1161(92)90033-I
  contributor:
    fullname: PE Tolbert
– volume: 2
  start-page: 410
  year: 2003
  ident: 2795_CR14
  publication-title: Genet Mol Res
  contributor:
    fullname: MG Martino-Roth
– volume: 40
  start-page: 86
  year: 2015
  ident: 2795_CR31
  publication-title: Environ Toxicol Pharmacol
  doi: 10.1016/j.etap.2015.05.007
  contributor:
    fullname: A Martín-Cameán
– volume: 312
  start-page: 39
  year: 1994
  ident: 2795_CR33
  publication-title: Mutat Res
  doi: 10.1016/0165-1161(94)90007-8
  contributor:
    fullname: N Titenko-Holland
– volume: 4
  start-page: 825
  year: 2009
  ident: 2795_CR10
  publication-title: Nat Protoc
  doi: 10.1038/nprot.2009.53
  contributor:
    fullname: P Thomas
– volume: 44
  start-page: 220
  year: 2008
  ident: 2795_CR22
  publication-title: Bucal Oncol
  contributor:
    fullname: M Bloching
– volume: 28
  start-page: 227
  year: 2005
  ident: 2795_CR8
  publication-title: An Sist Sanit Navar
  doi: 10.4321/S1137-66272005000300007
  contributor:
    fullname: M Zalacain
– volume: 23
  start-page: 221
  year: 2014
  ident: 2795_CR3
  publication-title: J Prosthodont
  doi: 10.1111/jopr.12100
  contributor:
    fullname: L Ristic
– volume: 22
  start-page: 3
  year: 2007
  ident: 2795_CR9
  publication-title: Mutagenesis
  doi: 10.1093/mutage/gel056
  contributor:
    fullname: M Fenech
– volume: 463
  start-page: 111
  year: 2000
  ident: 2795_CR5
  publication-title: Mutat Res
  doi: 10.1016/S1383-5742(00)00049-1
  contributor:
    fullname: RJ Albertini
– volume: 50
  start-page: 380
  year: 2003
  ident: 2795_CR23
  publication-title: Neoplasma
  contributor:
    fullname: M Konopacka
– volume: 659
  start-page: 93
  year: 2008
  ident: 2795_CR13
  publication-title: Mutat Res
  doi: 10.1016/j.mrrev.2008.03.007
  contributor:
    fullname: N Holland
– volume: 69
  start-page: 411
  year: 2008
  ident: 2795_CR4
  publication-title: J Orofac Orthop
  doi: 10.1007/s00056-008-0808-4
  contributor:
    fullname: E Petoumeno
– volume: 370
  start-page: 1453
  issue: 9596
  year: 2007
  ident: 2795_CR32
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)61602-X
  contributor:
    fullname: E von Elm
– volume: 29
  start-page: 325
  year: 2014
  ident: 2795_CR26
  publication-title: Mutagenesis
  doi: 10.1093/mutage/geu023
  contributor:
    fullname: A Katarkar
– volume: 22
  start-page: 371
  year: 2007
  ident: 2795_CR35
  publication-title: Mutagenesis
  doi: 10.1093/mutage/gem029
  contributor:
    fullname: P Thomas
– volume: 10
  start-page: 494
  year: 2013
  ident: 2795_CR30
  publication-title: J Dent
  contributor:
    fullname: F Heravi
– volume: 83
  start-page: 223
  year: 2000
  ident: 2795_CR1
  publication-title: J Prosthet Dent
  doi: 10.1016/S0022-3913(00)80016-5
  contributor:
    fullname: JC Wataha
SSID ssj0014673
Score 2.3135011
Snippet Objective This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare...
This study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare these to a...
ObjectiveThis study aimed to evaluate the genotoxic effects in the oral epithelial cells of patients undergoing fixed orthodontic treatment and to compare...
SourceID proquest
crossref
pubmed
springer
SourceType Aggregation Database
Index Database
Publisher
StartPage 2913
SubjectTerms Adolescent
Adult
Cheek
Child
Cross-Sectional Studies
Dentistry
DNA Damage
Epithelial cells
Female
Genotoxicity
Humans
Kruskal-Wallis test
Male
Medicine
Mucosa
Mutagenicity Tests
Original Article
Orthodontic Appliances, Fixed - adverse effects
Orthodontics
Orthodontics, Corrective
Patients
Sodium chloride
Statistical analysis
Young Adult
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Title Genotoxic effects in oral mucosal cells caused by the use of orthodontic fixed appliances in patients after short and long periods of treatment
URI https://link.springer.com/article/10.1007/s00784-018-02795-8
https://www.ncbi.nlm.nih.gov/pubmed/30612244
https://www.proquest.com/docview/2163554489
Volume 23
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