Pyrrole adducts in globin and plasma of workers exposed to hexane

• Published in: International archives of occupational and environmental health Vol. 92; no. 6; pp. 873 - 881
• Main Authors: Ichihara, Gaku, Amarnath, Venkataraman, Valentine, Holly L., Takeshita, Tatsuya, Morimoto, Kanehisa, Sobue, Tomotaka, Kawai, Toshio, Valentine, William M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019; Springer Nature B.V
• Subjects: Absorbance; Adducts; Biomarkers; Biomarkers - blood; Earth and Environmental Science; Environment; Environmental Health; Erythrocytes; Excretion; Exposure; Globins - chemistry; Globins - metabolism; Granulation; Hexanes - metabolism; Humans; Machining; Metal powders; Nervous system; Occupational exposure; Occupational Exposure - adverse effects; Occupational Medicine/Industrial Medicine; Original Article; Pepsin; Peripheral neuropathy; Plasma; Plasma - chemistry; Plasma proteins; Proteins; Pyrroles; Pyrroles - blood; Pyrroles - metabolism; Reagents; Rehabilitation; Slurries; Hexane; Neurotoxicity; Biomarker; Adduct; Pyrrole

Objectives Urinary excretion of 2,5-hexanedione is currently used to estimate the exposure levels of hexane occurring to an individual during the previous work shift. However, because hexane exposures and urinary 2,5-hexanedione levels can vary considerably from day to day, and subchronic to chronic...