The Influence of Naproxen on Biological Factors in Leukocyte-Rich Platelet-Rich Plasma: A Prospective Comparative Study

• Published in: Arthroscopy Vol. 35; no. 1; pp. 201 - 210
• Main Authors: Mannava, Sandeep, Whitney, Kaitlyn E., Kennedy, Mitchell I., King, Jill, Dornan, Grant J., Klett, Katarina, Chahla, Jorge, Evans, Thos A., Huard, Johnny, LaPrade, Robert F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Biological Factors - metabolism; Cytokines - metabolism; Female; Humans; Male; Middle Aged; Naproxen - pharmacology; Platelet-Derived Growth Factor - metabolism; Platelet-Rich Plasma - metabolism; Prospective Studies; Vascular Endothelial Growth Factor A - metabolism

To quantify and compare normative catabolic and anabolic factor concentrations in leukocyte-rich platelet-rich plasma (LR-PRP) at various time points, including baseline, 1 week after initiating naproxen use, and after a 1-week washout period. Asymptomatic healthy donors aged between 18 and 70 years...