Diabetes-Alzheimer's connection in older age: SGLT2 inhibitors as promising modulators of disease pathways

• Published in: Ageing research reviews Vol. 90; p. 102018
• Main Authors: Mancinetti, Francesca, Xenos, Dionysios, De Fano, Michelantonio, Mazzieri, Alessio, Porcellati, Francesca, Boccardi, Virginia, Mecocci, Patrizia
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.09.2023
• Subjects: Aging; Dementia; Diabetes; Drugs; Metabolism; Drugs; Aging; Diabetes; Metabolism; Dementia; dementia; metabolism; aging; drugs; diabetes

Late-onset Alzheimer's disease (LOAD) is the most frequent cause of dementia in older persons. Subjects affected by type 2 diabetes mellitus (T2DM) are at higher risk of vascular disease, cognitive decline, and dementia. LOAD has many characteristics shared with impaired insulin signaling pathw...