Impaired Responsiveness to the Platelet P2Y12 Receptor Antagonist Clopidogrel in Patients With Type 2 Diabetes and Coronary Artery Disease - Angiolillo, Dominick J.; Jakubowski, Joseph A.; Ferreiro, José Luis; Tello-Montoliu, Antonio; Rollini, Fabiana; Franchi, Francesco; Ueno, Masafumi; Darlington, Andrew; Desai, Bhaloo; Moser, Brian A.; Sugidachi, Atsuhiro; Guzman, Luis A.; et al. (Journal of the American College of Cardiology, 2014)
Keywords: Adult; Aged; Aspirin - adverse effects; Aspirin - therapeutic use; Biological and medical sciences; Cardiology. Vascular system; Cohort Studies; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - drug therapy; coronary disease; Coronary heart disease; diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Dose-Response Relationship, Drug; Drug Administration Schedule; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Follow-Up Studies; Heart; Humans; Male; Medical sciences; Middle Aged; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - therapeutic use; Platelet Function Tests; platelets; Prospective Studies; Purinergic P2Y Receptor Antagonists - adverse effects; Purinergic P2Y Receptor Antagonists - therapeutic use; Reference Values; Risk Assessment; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Treatment Outcome; PRI; DM; diabetes mellitus; ADP; PRP; coronary disease; ANCOVA; MFI; PRU; CYP; VASP; Cmax; AUC[0-tlast]; PGE1; CAD; LSM; platelets; VASP-P; ACS; Clop-AM; PD; LD; LTA; VN; PK; Endocrinopathy; Type 2 diabetes; Human; Metabolic diseases; Patient; Cardiovascular disease; Coronary heart disease; Antiplatelet agent; Platelet; Antithrombotic agent; Clopidogrel; Antagonist; Circulatory system; Thienopyridine derivative; Cardiology; Biological receptor