The pathogenicity of Th17 cells in autoimmune diseases

• Published in: Seminars in immunopathology Vol. 41; no. 3; pp. 283 - 297
• Main Authors: Yasuda, Keiko, Takeuchi, Yusuke, Hirota, Keiji
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2019; Springer Nature B.V
• Subjects: Animal models; Animals; Arthritis; Autoimmune diseases; Autoimmune Diseases - diagnosis; Autoimmune Diseases - etiology; Autoimmune Diseases - metabolism; Autoimmunity; Biomedical and Life Sciences; Biomedicine; Cell Differentiation - immunology; Cytokines; Cytokines - metabolism; Disease Susceptibility; Environmental effects; Environmental Exposure; Gastrointestinal Microbiome; Gene Expression Regulation; Granulocyte-macrophage colony-stimulating factor; Helper cells; Humans; Immunology; Inflammation Mediators - metabolism; Interleukin 17; Interleukin-17 - biosynthesis; Internal Medicine; Intestinal microflora; Lymphocyte Activation - immunology; Lymphocytes T; Microbiota; Pathogenicity; Phenotype; Review; Signal Transduction; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Th17 Cells - cytology; Th17 Cells - immunology; Th17 Cells - metabolism; EAE; Autoimmune arthritis; GM-CSF; Rheumatoid arthritis; IL-17; Th17 cells
• ISSN: 1863-2297; 1863-2300; 1863-2300
• DOI: 10.1007/s00281-019-00733-8

IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and GM-CSF secreted by autoimmune Th17 cells has been shown to be effective for the treatment of the diseases. Understanding a molecular...