Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left-right asymmetry
Understanding organ morphogenesis requires a precise geometrical description of the tissues involved in the process. The high morphological variability in mammalian embryos hinders the quantitative analysis of organogenesis. In particular, the study of early heart development in mammals remains a ch...
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Published in | Nature cardiovascular research Vol. 1; no. 5; p. 504 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.05.2022
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Abstract | Understanding organ morphogenesis requires a precise geometrical description of the tissues involved in the process. The high morphological variability in mammalian embryos hinders the quantitative analysis of organogenesis. In particular, the study of early heart development in mammals remains a challenging problem due to imaging limitations and complexity. Here, we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts. We develop strategies for morphometric staging and quantification of local morphological variations between specimens. We identify hot spots of regionalized variability and identify Nodal-controlled left-right asymmetry of the inflow tracts as the earliest signs of organ left-right asymmetry in the mammalian embryo. Finally, we generate a three-dimensional+t digital model that allows co-representation of data from different sources and provides a framework for the computer modeling of heart tube formation. |
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AbstractList | Understanding organ morphogenesis requires a precise geometrical description of the tissues involved in the process. The high morphological variability in mammalian embryos hinders the quantitative analysis of organogenesis. In particular, the study of early heart development in mammals remains a challenging problem due to imaging limitations and complexity. Here, we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts. We develop strategies for morphometric staging and quantification of local morphological variations between specimens. We identify hot spots of regionalized variability and identify Nodal-controlled left-right asymmetry of the inflow tracts as the earliest signs of organ left-right asymmetry in the mammalian embryo. Finally, we generate a three-dimensional+t digital model that allows co-representation of data from different sources and provides a framework for the computer modeling of heart tube formation. |
Author | Schmidt, Patrick Kobbelt, Leif Esteban, Isaac Raiola, Morena Torres, Miguel Temiño, Susana Desgrange, Audrey Meilhac, Sigolène M |
Author_xml | – sequence: 1 givenname: Isaac surname: Esteban fullname: Esteban, Isaac organization: Universidad Politécnica de Madrid, Madrid, Spain – sequence: 2 givenname: Patrick orcidid: 0000-0002-8917-3674 surname: Schmidt fullname: Schmidt, Patrick organization: Visual Computing Institute, RWTH Aachen University, Aachen, Germany – sequence: 3 givenname: Audrey surname: Desgrange fullname: Desgrange, Audrey organization: Unit of Heart Morphogenesis, Université de Paris, Imagine - Institut Pasteur, INSERM UMR1163, Paris, France – sequence: 4 givenname: Morena surname: Raiola fullname: Raiola, Morena organization: Universidad Politécnica de Madrid, Madrid, Spain – sequence: 5 givenname: Susana surname: Temiño fullname: Temiño, Susana organization: Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain – sequence: 6 givenname: Sigolène M surname: Meilhac fullname: Meilhac, Sigolène M organization: Unit of Heart Morphogenesis, Université de Paris, Imagine - Institut Pasteur, INSERM UMR1163, Paris, France – sequence: 7 givenname: Leif surname: Kobbelt fullname: Kobbelt, Leif organization: Visual Computing Institute, RWTH Aachen University, Aachen, Germany – sequence: 8 givenname: Miguel orcidid: 0000-0003-0906-4767 surname: Torres fullname: Torres, Miguel email: mtorres@cnic.es organization: Cardiovascular Regeneration Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. mtorres@cnic.es |
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Title | Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left-right asymmetry |
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