Increased mast cell abundance in adipose tissue of metabolic syndrome: relevance to the proinflammatory state and increased adipose tissue fibrosis

• Published in: American journal of physiology: endocrinology and metabolism Vol. 316; no. 3; pp. E504 - E509
• Main Authors: Gurung, Purnima, Moussa, Karine, Adams-Huet, Beverley, Devaraj, Sridevi, Jialal, Ishwarlal
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.03.2019
• Subjects: Adipose Tissue; Adult; Aged; Angiogenesis; Arteriosclerosis; Atherosclerosis; Biomarkers; Biopsy; Blood Glucose - metabolism; Blue stain; Cardiovascular diseases; Case-Control Studies; Chemokines - metabolism; Correlation; Diabetes; Diabetes mellitus; Female; Fibrosis; Histamine; Humans; Immune system; Immunohistochemistry; Inflammation; Insulin; Insulin Resistance; Interleukin 6; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Leptin; Leptin - metabolism; Male; MAP kinase; Mast cells; Mast Cells - immunology; Mast Cells - pathology; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - immunology; Metabolic Syndrome - metabolism; Metabolic Syndrome - pathology; Middle Aged; Monocytes; Monocytes - metabolism; Neovascularization, Pathologic; NF-kappa B - metabolism; Organic chemistry; p38 Mitogen-Activated Protein Kinases - metabolism; Pathogenesis; Subcutaneous Fat - immunology; Subcutaneous Fat - pathology; Triglycerides; Triglycerides - metabolism; Tryptase; Waist Circumference; Young Adult; metabolic syndrome; subcutaneous adipose tissue; fibrosis; mast cells; inflammation; insulin resistance

Metabolic Syndrome (MetS) affects 35% of American adults > 40 yr and portends an increased risk for both atherosclerotic cardiovascular disease (ASCVD) and diabetes. The role of mast cells in the proinflammatory state of MetS is not well elucidated. We propose that mast cells in subcutaneous adip...