Gingival crevicular fluid levels of osteoprotegerin (OPG) in premenopausal and postmenopausal women with or without chronic periodontitis

• Published in: Journal of dentistry Vol. 40; no. 5; pp. 364 - 371
• Main Authors: Babür, Ceren, Özcan, Gönen, Çebi, Dilek Uç, Pervane, Beste, Özdemir, Burcu, Yücel, Ayşegül, Biri, Aydan Asyalı, Babür, Cahit
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2012; Elsevier Limited
• Subjects: Absorptiometry, Photon; Aged; Bone biology; Bone density; Bone Density - physiology; Case-Control Studies; Chronic Periodontitis - immunology; Chronic Periodontitis - therapy; Cytokine(s); Dental Plaque Index; Dental Scaling - methods; Dentistry; Estrogens - blood; Female; Gingival crevicular fluid; Gingival Crevicular Fluid - immunology; Gingival Hemorrhage - classification; Gingival Hemorrhage - therapy; Gingivitis - immunology; Gynaecology; Humans; Lumbar Vertebrae - pathology; Menopause; Middle Aged; Non-surgical periodontal therapy; Oral hygiene; Osteoporosis; Osteoprotegerin - analysis; Periodontal Attachment Loss - classification; Periodontal Attachment Loss - therapy; Periodontal Index; Periodontal Pocket - classification; Periodontal Pocket - therapy; Periodontal-systemic disease interactions; Periodontitis; Postmenopause - blood; Postmenopause - immunology; Premenopause - blood; Premenopause - immunology; Root Planing - methods; Studies; Gynaecology; Cytokine(s); Periodontitis; Bone biology; Non-surgical periodontal therapy; Periodontal-systemic disease interactions; Gingival crevicular fluid
• ISSN: 0300-5712; 1879-176X
• DOI: 10.1016/j.jdent.2012.01.013

Abstract Objectives Systemic conditions may affect host susceptibility, disease progression and severity as well as treatment response. Previously, low oestrogen (E2 ) levels were associated with increased bone resorption, due to increased osteoclastogenesis and decreased osteoclast apoptosis. Osteoprotegerin (OPG) is an essential cytokine for osteoclastogenesis. The aim of this study was to evaluate gingival crevicular fluid (GCF) OPG levels in menopausal and premenopausal patients with or without periodontitis, and effects of phase I periodontal therapy on GCF OPG levels. Methods Forty-four systemically healthy premenopausal and menopausal patients were recruited and divided into subgroups of periodontitis and control. Bone mineral density (BMD) and serum E2 levels were measured. Before and after phase I periodontal therapy clinical indices, including clinical attachment levels (CAL) were recorded, and GCF samples were collected. GCF OPG levels were detected by enzyme-linked immunosorbent assay. Repeated measurement ANOVA and Spearman correlation tests were used. Results All clinical indices improved significantly after treatment( p < 0.001), except Pre-M/C groups CAL reduction( p > 0.05). Periodontitis groups’ OPG levels were lower than gingivitis groups( p > 0.05). Following periodontal phase I therapy, GCF OPG levels increased markedly in all groups, however this alteration was found statistically insignificant ( p > 0.05). Conclusions The current data revealed that GCF OPG levels were lower in periodontitis patients and phase I therapy resulted with increased GCF OPG levels, however those alterations were statistically insignificant. In addition, present data suggested that menopause do not seem to have a significant effect on periodontal status or response to phase I treatment, within the limits of this study.