The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis

Aims Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’ diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-a...

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Published inActa diabetologica Vol. 58; no. 6; pp. 671 - 685
Main Authors You, Yue, Liu, Zhizhen, Chen, Yannan, Xu, Ying, Qin, Jiawei, Guo, Shuai, Huang, Jia, Tao, Jing
Format Journal Article
LanguageEnglish
Published Milan Springer Milan 01.06.2021
Springer Nature B.V
Subjects
Alzheimer's disease
Cognitive ability
Diabetes
Diabetes mellitus (non-insulin dependent)
Health Education and psycho-social aspects
Internal Medicine
Medicine
Medicine & Public Health
Meta-analysis
Metabolic Diseases
Neurodegenerative diseases
Review Article
Risk factors
Sensitivity analysis
Systematic review
Asia
Prevalence
Type 2 diabetes mellitus
Mild cognitive impairment
Dementia
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Abstract Aims Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’ diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies. Methods We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16. Results A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe ( n =2, r =36.6%, 95% CI=26.3, 46.9, I 2 =82.3%) had a lower prevalence than Asia ( n =10, r =46.4%, 95% CI=36.2, 56.6, I 2 =98%). The overall prevalence in female patients ( n =14, r =46.9%, 95% CI=34, 59.8, I 2 =98.3%) was higher than that in male patients ( n =14, r =38.8%, 95% CI=27, 50.7, I 2 =98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years ( n =9, r =44.3%, 95% CI=33.1, 55.6, I 2 =98.3%) than patients younger than 60 years ( n =3, r =46.4%, 95% CI=33.3, 59.5, I 2 =91.2%). Conclusion Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.
AbstractList AimsMild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’ diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies.MethodsWe carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16.ResultsA total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I2=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I2=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I2=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I2=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I2=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I2=91.2%).ConclusionOur results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.
Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies.AIMSMild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies.We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16.METHODSWe carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16.A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I2=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I2=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I2=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I2=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I2=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I2=91.2%).RESULTSA total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I2=82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I2=98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I2=98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I2=98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I2=98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I2=91.2%).Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.CONCLUSIONOur results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.
Aims Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’ diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies. Methods We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16. Results A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe ( n =2, r =36.6%, 95% CI=26.3, 46.9, I 2 =82.3%) had a lower prevalence than Asia ( n =10, r =46.4%, 95% CI=36.2, 56.6, I 2 =98%). The overall prevalence in female patients ( n =14, r =46.9%, 95% CI=34, 59.8, I 2 =98.3%) was higher than that in male patients ( n =14, r =38.8%, 95% CI=27, 50.7, I 2 =98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years ( n =9, r =44.3%, 95% CI=33.1, 55.6, I 2 =98.3%) than patients younger than 60 years ( n =3, r =46.4%, 95% CI=33.3, 59.5, I 2 =91.2%). Conclusion Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.
Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic conditions. This study aimed to estimate the prevalence of MCI in T2DM (T2DM-MCI) patients by conducting a systematic review and meta-analysis of observational studies. We carried out a literature search until June 1, 2020, for all observational studies in the following databases: Medline (PubMed), Web of Science, and Embase. Two independent reviewers initially screened the eligible articles. Then, a meta-analysis (random effects model) was conducted to estimate the prevalence of MCI in people with T2DM with STATA 16. A total of 1808 articles were first considered after reading title and abstract, 12 of which remained after reviewing the full text. The combined prevalence of MCI in T2DM patients was estimated to be 45.0% (95% CI=36.0, 54.0). There was no significant heterogeneity through meta-regression and sensitivity analysis. Overall, Europe (n=2, r=36.6%, 95% CI=26.3, 46.9, I =82.3%) had a lower prevalence than Asia (n=10, r=46.4%, 95% CI=36.2, 56.6, I =98%). The overall prevalence in female patients (n=14, r=46.9%, 95% CI=34, 59.8, I =98.3%) was higher than that in male patients (n=14, r=38.8%, 95% CI=27, 50.7, I =98%). Subgroup analysis based on age demonstrated a lower prevalence in patients older than 60 years (n=9, r=44.3%, 95% CI=33.1, 55.6, I =98.3%) than patients younger than 60 years (n=3, r=46.4%, 95% CI=33.3, 59.5, I =91.2%). Our results demonstrate that the pooled estimated prevalence of mild cognitive impairment in type 2 diabetes mellitus patients is high worldwide, especially in China Asia. Primary care clinicians should pay more attention to the cognitive function of T2DM patients, as mild cognitive impairment is one of the risk factors for Alzheimer's disease.
Author Guo, Shuai
Xu, Ying
You, Yue
Qin, Jiawei
Chen, Yannan
Liu, Zhizhen
Tao, Jing
Huang, Jia
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  organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fujian Key Laboratory of Rehabilitation Technology, Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education
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  surname: Tao
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  organization: College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fujian Key Laboratory of Rehabilitation Technology, Key Laboratory of Orthopedics and Traumatology of Traditional Chinese Medicine and Rehabilitation, Fujian University of Traditional Chinese Medicine, Ministry of Education
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33417039$$D View this record in MEDLINE/PubMed
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Copyright Springer-Verlag Italia S.r.l., part of Springer Nature 2021
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Issue 6
Keywords Prevalence
Type 2 diabetes mellitus
Mild cognitive impairment
Dementia
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PublicationTitle Acta diabetologica
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Snippet Aims Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’...
Mild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients' diabetic...
AimsMild Cognitive impairment (MCI) is common in type 2 diabetes mellitus (T2DM) patients. The impaired cognitive function had harmful effect on patients’...
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crossref
springer
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SubjectTerms Alzheimer's disease
Cognitive ability
Diabetes
Diabetes mellitus (non-insulin dependent)
Health Education and psycho-social aspects
Internal Medicine
Medicine
Medicine & Public Health
Meta-analysis
Metabolic Diseases
Neurodegenerative diseases
Review Article
Risk factors
Sensitivity analysis
Systematic review
Title The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis
URI https://link.springer.com/article/10.1007/s00592-020-01648-9
https://www.ncbi.nlm.nih.gov/pubmed/33417039
https://www.proquest.com/docview/2524919723
https://www.proquest.com/docview/2476564005
Volume 58
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