Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis

• Published in: Inflammation research Vol. 71; no. 7-8; pp. 741 - 758
• Main Authors: Facchin, Bruno Matheus, dos Reis, Gustavo Oliveira, Vieira, Guilherme Nicácio, Mohr, Eduarda Talita Bramorski, da Rosa, Júlia Salvan, Kretzer, Iara Fabricia, Demarchi, Izabel Galhardo, Dalmarco, Eduardo Monguilhott
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2022; Springer Nature B.V
• Subjects: Allergology; Animals; Anti-inflammatory agents; Anti-Inflammatory Agents - pharmacology; Biomarkers; Biomedical and Life Sciences; Biomedicine; Cell density; Dermatology; Drug development; IL-1β; Immunology; Inflammation; Inflammation Mediators; Interleukin 6; Interleukin-1beta - pharmacology; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Macrophages; Meta-analysis; Mice; Neurology; NF-kappa B; Nitric Oxide; Pharmacology/Toxicology; RAW 264.7 Cells; Review; Reviews; Rheumatology; Systematic review; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumor necrosis factor-alpha; In vitro techniques; Nitricde; Lipopolysaccharide; Interleukin- 6; Macrophages; Interleukin-1 beta; RAW 264.7 cells

Introduction Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possib...