Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis

Introduction Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possib...

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Published inInflammation research Vol. 71; no. 7-8; pp. 741 - 758
Main Authors Facchin, Bruno Matheus, dos Reis, Gustavo Oliveira, Vieira, Guilherme Nicácio, Mohr, Eduarda Talita Bramorski, da Rosa, Júlia Salvan, Kretzer, Iara Fabricia, Demarchi, Izabel Galhardo, Dalmarco, Eduardo Monguilhott
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.08.2022
Springer Nature B.V
Subjects
Allergology
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell density
Dermatology
Drug development
IL-1β
Immunology
Inflammation
Inflammation Mediators
Interleukin 6
Interleukin-1beta - pharmacology
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Macrophages
Meta-analysis
Mice
Neurology
NF-kappa B
Nitric Oxide
Pharmacology/Toxicology
RAW 264.7 Cells
Review
Reviews
Rheumatology
Systematic review
Tumor Necrosis Factor-alpha - pharmacology
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Tumor necrosis factor-alpha
In vitro techniques
Nitricde
Lipopolysaccharide
Interleukin- 6
Macrophages
Interleukin-1 beta
RAW 264.7 cells
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Abstract Introduction Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA). Methodology We conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework ( https://doi.org/10.17605/OSF.IO/8C3HT ). Results LPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems. Conclusion Measurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.
AbstractList Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA).INTRODUCTIONSeveral experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA).We conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework ( https://doi.org/10.17605/OSF.IO/8C3HT ).METHODOLOGYWe conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework ( https://doi.org/10.17605/OSF.IO/8C3HT ).LPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems.RESULTSLPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems.Measurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.CONCLUSIONMeasurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.
Introduction Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA). Methodology We conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework ( https://doi.org/10.17605/OSF.IO/8C3HT ). Results LPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems. Conclusion Measurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.
IntroductionSeveral experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA).MethodologyWe conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework (https://doi.org/10.17605/OSF.IO/8C3HT).ResultsLPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems.ConclusionMeasurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.
Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been widely used. However, there is still no consensus on which inflammatory mediators should initially be measured to screen for possible anti-inflammatory effects. To determine the rationality of measuring inflammatory mediators together with NO, such as the levels of tumor necrosis factor (TNF)-α, and interleukins (IL) 1β and 6, we carried out this systematic review (SR) and meta-analysis (MA). We conducted this SR and MA in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis and the Cochrane Handbook for Systematic Reviews of Intervention. This review was registered in the Open Science Framework ( https://doi.org/10.17605/OSF.IO/8C3HT ). LPS-induced cells produced high NO levels compared to non-LPS induced, and this production was not related to cell density. TNF-α, IL-1β, and IL-6, also showed high levels after cells had been stimulated with LPS. Though with some restrictions, all studies were reliable, as the risk of bias was detected in the test compounds and systems. Measurement of NO levels may be sufficient to screen for possible anti-inflammatory action in the context of LPS-induced RAW 264.7 cells.
Author dos Reis, Gustavo Oliveira
Facchin, Bruno Matheus
Demarchi, Izabel Galhardo
Vieira, Guilherme Nicácio
Dalmarco, Eduardo Monguilhott
Mohr, Eduarda Talita Bramorski
da Rosa, Júlia Salvan
Kretzer, Iara Fabricia
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  fullname: Demarchi, Izabel Galhardo
  organization: Programa de Pós-Graduação Em Farmácia (PPGFar), Universidade Federal de Santa Catarina, Departamento de Análises Clínicas–CCS, Universidade Federal de Santa Catarina, Programa de Pós-Graduação Em Ciências da Saúde, Universidade Estadual de Maringá
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  organization: Programa de Pós-Graduação Em Farmácia (PPGFar), Universidade Federal de Santa Catarina, Departamento de Análises Clínicas–CCS, Universidade Federal de Santa Catarina
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35612604$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1136/bmj.n71
10.1016/j.jep.2009.06.027
10.1038/s41573-020-0082-8
10.1038/sigtrans.2017.23
10.1016/j.atherosclerosis.2019.02.017
10.1080/10715760400017327
10.1186/s12906-017-1635-1
10.14814/phy2.13914
10.1038/nrmicro2539
10.1155/2019/6474168
10.3390/ijms20184367
10.4014/jmb.1901.01027
10.1016/j.intimp.2017.05.021
10.1016/j.cell.2010.02.029
10.3892/mmr.2017.6166
10.1186/1471-2288-5-13
10.1371/journal.pone.0121327
10.3389/fimmu.2016.00160/abstract
10.3389/fimmu.2020.01210/full
10.1016/j.amjms.2020.06.007
10.1016/j.jdermsci.2015.06.012
10.1016/j.foodchem.2016.01.114
10.1002/jat.3648
10.1006/bcmd.1998.0201
10.1039/C9FO01500K
10.22159/ajpcr.2018.v11i11.26873
10.1016/j.foodchem.2017.12.015
10.1101/cshperspect.a001651
10.1371/journal.pone.0198943
10.1016/j.fct.2013.05.061
10.1016/j.chroma.2019.460362
10.1038/nrd.2016.39
10.1016/j.foodres.2017.07.032
10.1038/s41591-019-0675-0
10.18311/jnr/2016/5367
10.3892/mmr.2019.10746
10.1002/9781119536604
10.1186/s13643-016-0384-4
10.1159/000495922
10.1146/annurev-pathol-012414-040418
10.1139/cjpp-2014-0362
10.1016/j.biopha.2017.06.036
10.31925/farmacia.2019.6.17
10.4142/jvs.2020.21.e91
10.1021/acs.jnatprod.8b00036
10.1016/j.cell.2010.03.006
10.21010/ajtcam.v13i4.10
10.1007/s00018-020-03656-y
10.1016/j.jep.2014.11.032
10.1016/0003-2697(82)90118-X
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022
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Issue 7-8
Keywords Tumor necrosis factor-alpha
In vitro techniques
Nitricde
Lipopolysaccharide
Interleukin- 6
Macrophages
Interleukin-1 beta
RAW 264.7 cells
Language English
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PublicationSubtitle Official Journal of: The International Association of Inflammation Societies + The European Histamine Research Society
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References Moore K, Howard L, Brownmiller C, Gu I, Lee S-O, Mauromoustakos A. Inhibitory effects of cranberry polyphenol and volatile extracts on nitric oxide production in LPS activated RAW 264.7 macrophages. Food Funct [Internet]. 2019 [cited 2020 Apr 1];10(11):7091–102. Available from: http://xlink.rsc.org/?DOI=C9FO01500K
Kim YS, Ahn CB, Je JY. Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-kappa B and MAPK pathways. Food Chem. 2016;202:9–14.
Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol [Internet]. 2005;5(1):13. Available from: http://bmcmedresmethodol.biomedcentral.com/articles/https://doi.org/10.1186/1471-2288-5-13
Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther [Internet]. 2017;2(1):17023. Available from: http://www.nature.com/articles/sigtrans201723
Taciak B, Białasek M, Braniewska A, Sas Z, Sawicka P, Kiraga Ł, et al. Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages. Roberts DD, editor. PLoS One [Internet]. 2018;13(6):e0198943. Available from: https://dx.plos.org/https://doi.org/10.1371/journal.pone.0198943
Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS. Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages. Food Chem Toxicol [Internet]. 2013;59:199–206. Available from: https://linkinghub.elsevier.com/retrieve/pii/S027869151300375X
Meram C, Wu J. Anti-inflammatory effects of egg yolk livetins (α, β, and γ-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages. Food Res Int [Internet]. 2017;100:449–59. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0963996917303563
Lim D, Kim MK, Jang Y-P, Kim J. Sceptridium ternatum attenuates allergic contact dermatitis-like skin lesions by inhibiting T helper 2-type immune responses and inflammatory responses in a mouse model. J Dermatol Sci [Internet]. 2015;79(3):288–97. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0923181115300165
KabirIAnsariIa Review on in vivo and in vitro experimental models to investigate the anti-inflammatory activity of herbal extractsAsian J Pharm Clin Res20181111291:CAS:528:DC%2BC1MXhtFWrt7zL10.22159/ajpcr.2018.v11i11.26873
Hobbs S, Reynoso M, Geddis A V, Mitrophanov AY, Matheny RW. LPS-stimulated NF-kappa B p65 dynamic response marks the initiation of TNF expression and transition to IL-10 expression in RAW 264.7 macrophages. Physiol Rep. 2018;6(21).
Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM. Resolution of inflammation: What controls its onset? Front Immunol [Internet]. 2016;7(APR). Available from: http://journal.frontiersin.org/Article/https://doi.org/10.3389/fimmu.2016.00160/abstract
Duarte LJ, Chaves VC, Nascimento MVP dos S, Calvete E, Li M, Ciraolo E, et al. Molecular mechanism of action of Pelargonidin-3- O -glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. Food Chem [Internet]. 2018;247:56–65. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0308814617319544
Pang Y, Gan L, Wang X, Su Q, Liang C, He P. Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE mice and lipopolysaccharide-stimulated RAW264.7 macrophages. Atherosclerosis [Internet]. 2019;284:50–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0021915019301030
Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ, et al. Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals. Int J Mol Sci [Internet]. 2019;20(18):4367. Available from: https://www.mdpi.com/1422-0067/20/18/4367
Mohr ETB, dos Santos Nascimento MVP, da Rosa JS, Vieira GN, Kretzer IF, Sandjo LP, et al. Evidence that the anti-inflammatory effect of rubiadin-1-methyl ether has an immunomodulatory context. Mediators Inflamm [Internet]. 2019;2019:1–12. Available from: https://www.hindawi.com/journals/mi/2019/6474168
CicchittiLMartelliMCerritelliFChronic inflammatory disease and osteopathy: A systematic reviewPLoS One201510311810.1371/journal.pone.0121327
Biluca FC, da Silva B, Caon T, Mohr ETB, Vieira GN, Gonzaga L V, et al. Investigation of phenolic compounds, antioxidant and anti-inflammatory activities in stingless bee honey (Meliponinae). Food Res Int [Internet]. 2020;129. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076113286&doi=10.1016%2Fj.foodres.2019.108756&partnerID=40&md5=532c50458a5140f6e7c1726ebc103f8f
He C, Lin H, Wang C, Zhang M, Lin Y, Huang F, et al. Exopolysaccharide from Paecilomyces lilacinus modulates macrophage activities through the TLR4/NF‑κB/MAPK pathway. Mol Med Rep [Internet]. 2019;20:4943–52. Available from: http://www.spandidos-publications.com/https://doi.org/10.3892/mmr.2019.10746
Sun H, Cai W, Wang X, Liu Y, Hou B, Zhu X, et al. Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells. BMC Complement Altern Med [Internet]. 2017;17(1):120. Available from: http://bmccomplementalternmed.biomedcentral.com/articles/https://doi.org/10.1186/s12906-017-1635-1
Lim D, Lee E, Jeong E, Jang Y-P, Kim J. Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro. J Ethnopharmacol [Internet]. 2015;160:41–51. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874114008162
Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med [Internet]. 2019;25(12):1822–32. Available from: http://www.nature.com/articles/s41591-019-0675-0
CiesielskaAMatyjekMKwiatkowskaKTLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signalingCell Mol Life Sci.20217841233611:CAS:528:DC%2BB3cXitVyhs7%2FJ10.1007/s00018-020-03656-y33057840
Lind M, Hayes A, Caprnda M, Petrovic D, Rodrigo L, Kruzliak P, et al. Inducible nitric oxide synthase: Good or bad? Biomed Pharmacother [Internet]. 2017;93:370–5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0753332217313562
SahaBKBurnsSLThe story of nitric oxide, sepsis and methylene blue: a comprehensive pathophysiologic reviewAm J Med Sci.202036043293710.1016/j.amjms.2020.06.00732631574
Laksmitawati DR, Prasanti AP, Larasinta N, Syauta GA, Hilda R, Ramadaniati HU, et al. Anti-Inflammatory Potential of Gandarusa (Gendarussa vulgaris Nees) and Soursop (Annona muricata L) Extracts in LPS Stimulated-Macrophage Cell (RAW264.7). J Nat Remedies [Internet]. 2016;16(2):73. Available from: http://www.informaticsjournals.com/index.php/jnr/article/view/5367
Altan A, Yuce H, Karataş O, Taşkan M, Gevrek F, Çolak S, et al. Free and liposome form of gallic acid improves calvarial bone wound healing in Wistar rats. Asian Pac J Trop Biomed [Internet]. 2020;10(4):156–63. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082821467&doi=10.4103%2F2221-1691.280297&partnerID=40&md5=276ab92945ffa8b6630ea0ccc384717d
LawrenceTThe nuclear factor NF-kappaB pathway in inflammationCold Spring Harb Perspect Biol20091611010.1101/cshperspect.a001651
Giustarini D, Dalle-Donne I, Colombo R, Milzani A, Rossi R. Adaptation of the Griess Reaction for Detection of Nitrite in Human Plasma. Free Radic Res [Internet]. 2004;38(11):1235–40. Available from: http://www.tandfonline.com/doi/full/https://doi.org/10.1080/10715760400017327
Lee S-B, Lee WS, Shin J-S, Jang DS, Lee KT. Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages. Int Immunopharmacol [Internet]. 2017;49:21–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1567576917301947
PoltorakASmirnovaIHeXLiuM-YVanHCBirdwellDGenetic and physical mapping of the Lps Locus: identification of the toll-4 receptor as a candidate gene in the critical regionBlood Cells, Mol Dis199824017034035510.1006/bcmd.1998.0201
Kim M-J, Jeong S-M, Kang B-K, Kim K-B-W-R, Ahn D-H. Anti-Inflammatory Effects of Grasshopper Ketone from Sargassum fulvellum Ethanol Extract on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells. J Microbiol Biotechnol [Internet]. 2019;29(5):820–6. Available from: http://www.jmb.or.kr/journal/view.html?doi=https://doi.org/10.4014/jmb.1901.01027
Ghate NB, Chaudhuri D, Panja S, Singh SS, Gupta G, Lee CY, et al. In Vitro Mechanistic Study of the Anti-inflammatory Activity of a Quinoline Isolated from Spondias pinnata Bark. J Nat Prod [Internet]. 2018;81(9):1956–61. Available from: https://pubs.acs.org/doi/https://doi.org/10.1021/acs.jnatprod.8b00036
Karatoprak GS, Pasayeva L, Safak EK, Göger F, Tugay O, Kosar M. Chemical composition and anti-inflammatory activity of Kitaibelia balansae BOISS. Farmacia [Internet]. 2019;67(6):1054–9. Available from: http://farmaciajournal.com/issue-articles/chemical-composition-and-anti-inflammatory-activity-of-kitaibelia-balansae-boiss
PageMJMcKenzieJEBossuytPMBoutronIHoffmannTCMulrowCDThe PRISMA statement: an updated guideline for reporting systematic reviewsBMJ.202010.1136/bmj.n7132933948
Urbaniak GC, Plous S. Research Randomizer (Version 4.0). 2013.
Zhang Y, Yan R, Hu Y. Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like receptor 4/nuclear factor-kappa B in macrophages. Can J Physiol Pharmacol [Internet]. 2015;93(4):253–60. Available from: http://www.nrcresearchpress.com/doi/https://doi.org/10.1139/cjpp-2014-0362
Medzhitov R. Inflammation 2010: New Adventures of an Old Flame. Cell [Internet]. 2010;140(6):771–6. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20303867
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Syst
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References_xml – reference: Lee S-B, Lee WS, Shin J-S, Jang DS, Lee KT. Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages. Int Immunopharmacol [Internet]. 2017;49:21–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1567576917301947
– reference: Karatoprak GS, Pasayeva L, Safak EK, Göger F, Tugay O, Kosar M. Chemical composition and anti-inflammatory activity of Kitaibelia balansae BOISS. Farmacia [Internet]. 2019;67(6):1054–9. Available from: http://farmaciajournal.com/issue-articles/chemical-composition-and-anti-inflammatory-activity-of-kitaibelia-balansae-boiss/
– reference: Romerio A, Peri F. Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Overview. Front Immunol [Internet]. 2020;11. Available from: https://www.frontiersin.org/article/https://doi.org/10.3389/fimmu.2020.01210/full
– reference: Medzhitov R. Inflammation 2010: New Adventures of an Old Flame. Cell [Internet]. 2010;140(6):771–6. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20303867
– reference: Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang K-J, et al. Engineered In Vitro Disease Models. Annu Rev Pathol Mech Dis [Internet]. 2015;10(1):195–262. Available from: http://www.annualreviews.org/doi/https://doi.org/10.1146/annurev-pathol-012414-040418
– reference: PoltorakASmirnovaIHeXLiuM-YVanHCBirdwellDGenetic and physical mapping of the Lps Locus: identification of the toll-4 receptor as a candidate gene in the critical regionBlood Cells, Mol Dis199824017034035510.1006/bcmd.1998.0201
– reference: LawrenceTThe nuclear factor NF-kappaB pathway in inflammationCold Spring Harb Perspect Biol20091611010.1101/cshperspect.a001651
– reference: Duarte LJ, Chaves VC, Nascimento MVP dos S, Calvete E, Li M, Ciraolo E, et al. Molecular mechanism of action of Pelargonidin-3- O -glucoside, the main anthocyanin responsible for the anti-inflammatory effect of strawberry fruits. Food Chem [Internet]. 2018;247:56–65. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0308814617319544
– reference: Zhang Y, Yan R, Hu Y. Oxymatrine inhibits lipopolysaccharide-induced inflammation by down-regulating Toll-like receptor 4/nuclear factor-kappa B in macrophages. Can J Physiol Pharmacol [Internet]. 2015;93(4):253–60. Available from: http://www.nrcresearchpress.com/doi/https://doi.org/10.1139/cjpp-2014-0362
– reference: Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol [Internet]. 2005;5(1):13. Available from: http://bmcmedresmethodol.biomedcentral.com/articles/https://doi.org/10.1186/1471-2288-5-13
– reference: Lee HA, Koh EK, Sung JE, Kim JE, Song SH, Kim DS, et al. Ethyl acetate extract from Asparagus cochinchinensis exerts anti-inflammatory effects in LPS-stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti-oxidant activity. Mol Med Rep [Internet]. 2017;15(4):1613–23. Available from: https://www.spandidos-publications.com/https://doi.org/10.3892/mmr.2017.6166
– reference: Dai B, Wei D, Zheng N, Chi Z, Xin N, Ma T, et al. Coccomyxa Gloeobotrydiformis Polysaccharide Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages. Cell Physiol Biochem [Internet]. 2018 [cited 2020 Apr 1];51(6):2523–35. Available from: https://www.karger.com/Article/FullText/495922
– reference: American type culture collection (ATCC). ATCC Raw 264.7 (ATCC® TIB71™) product sheet. American Type Collection Culture. EUA, 2018.
– reference: Kim YS, Ahn CB, Je JY. Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-kappa B and MAPK pathways. Food Chem. 2016;202:9–14.
– reference: Elisia I, Pae HB, Lam V, Cederberg R, Hofs E, Krystal G. Comparison of RAW264.7, human whole blood and PBMC assays to screen for immunomodulators. J Immunol Methods [Internet]. 2018;452:26–31. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031664464&doi=10.1016%2Fj.jim.2017.10.004&partnerID=40&md5=00ac5160d32a7297d3898e2807a5bb86
– reference: Giustarini D, Dalle-Donne I, Colombo R, Milzani A, Rossi R. Adaptation of the Griess Reaction for Detection of Nitrite in Human Plasma. Free Radic Res [Internet]. 2004;38(11):1235–40. Available from: http://www.tandfonline.com/doi/full/https://doi.org/10.1080/10715760400017327
– reference: Pang Y, Gan L, Wang X, Su Q, Liang C, He P. Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE mice and lipopolysaccharide-stimulated RAW264.7 macrophages. Atherosclerosis [Internet]. 2019;284:50–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0021915019301030
– reference: Lim D, Lee E, Jeong E, Jang Y-P, Kim J. Stemona tuberosa prevented inflammation by suppressing the recruitment and the activation of macrophages in vivo and in vitro. J Ethnopharmacol [Internet]. 2015;160:41–51. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874114008162
– reference: Kim Y-S, Ahn C-B, Je J-Y. Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-κB and MAPK pathways. Food Chem [Internet]. 2016;202:9–14. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0308814616301121
– reference: Moore K, Howard L, Brownmiller C, Gu I, Lee S-O, Mauromoustakos A. Inhibitory effects of cranberry polyphenol and volatile extracts on nitric oxide production in LPS activated RAW 264.7 macrophages. Food Funct [Internet]. 2019 [cited 2020 Apr 1];10(11):7091–102. Available from: http://xlink.rsc.org/?DOI=C9FO01500K
– reference: Patil KR, Mahajan UB, Unger BS, Goyal SN, Belemkar S, Surana SJ, et al. Animal models of inflammation for screening of anti-inflammatory drugs: implications for the discovery and development of phytopharmaceuticals. Int J Mol Sci [Internet]. 2019;20(18):4367. Available from: https://www.mdpi.com/1422-0067/20/18/4367
– reference: Taciak B, Białasek M, Braniewska A, Sas Z, Sawicka P, Kiraga Ł, et al. Evaluation of phenotypic and functional stability of RAW 264.7 cell line through serial passages. Roberts DD, editor. PLoS One [Internet]. 2018;13(6):e0198943. Available from: https://dx.plos.org/https://doi.org/10.1371/journal.pone.0198943
– reference: Rahman MM, McFadden G. Modulation of NF-κB signalling by microbial pathogens. Nat Rev Microbiol [Internet]. 2011;9(4):291–306. Available from: http://www.nature.com/articles/nrmicro2539
– reference: Sun H, Cai W, Wang X, Liu Y, Hou B, Zhu X, et al. Vaccaria hypaphorine alleviates lipopolysaccharide-induced inflammation via inactivation of NFκB and ERK pathways in Raw 264.7 cells. BMC Complement Altern Med [Internet]. 2017;17(1):120. Available from: http://bmccomplementalternmed.biomedcentral.com/articles/https://doi.org/10.1186/s12906-017-1635-1
– reference: Sugimoto MA, Sousa LP, Pinho V, Perretti M, Teixeira MM. Resolution of inflammation: What controls its onset? Front Immunol [Internet]. 2016;7(APR). Available from: http://journal.frontiersin.org/Article/https://doi.org/10.3389/fimmu.2016.00160/abstract
– reference: CiesielskaAMatyjekMKwiatkowskaKTLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signalingCell Mol Life Sci.20217841233611:CAS:528:DC%2BB3cXitVyhs7%2FJ10.1007/s00018-020-03656-y33057840
– reference: KabirIAnsariIa Review on in vivo and in vitro experimental models to investigate the anti-inflammatory activity of herbal extractsAsian J Pharm Clin Res20181111291:CAS:528:DC%2BC1MXhtFWrt7zL10.22159/ajpcr.2018.v11i11.26873
– reference: Ghate NB, Chaudhuri D, Panja S, Singh SS, Gupta G, Lee CY, et al. In Vitro Mechanistic Study of the Anti-inflammatory Activity of a Quinoline Isolated from Spondias pinnata Bark. J Nat Prod [Internet]. 2018;81(9):1956–61. Available from: https://pubs.acs.org/doi/https://doi.org/10.1021/acs.jnatprod.8b00036
– reference: NathanCDingANonresolving InflammationCell201014068718821:CAS:528:DC%2BC3cXlsVSgu7s%3D10.1016/j.cell.2010.02.029
– reference: Green LC, Wagner D a, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126:131–8.
– reference: Zarrin AA, Bao K, Lupardus P, Vucic D. Kinase inhibition in autoimmunity and inflammation. Nat Rev Drug Discov [Internet]. 2021;20(1):39–63. Available from: http://www.nature.com/articles/s41573-020-0082-8
– reference: Mohr ETB, dos Santos Nascimento MVP, da Rosa JS, Vieira GN, Kretzer IF, Sandjo LP, et al. Evidence that the anti-inflammatory effect of rubiadin-1-methyl ether has an immunomodulatory context. Mediators Inflamm [Internet]. 2019;2019:1–12. Available from: https://www.hindawi.com/journals/mi/2019/6474168/
– reference: Yoon S-B, Lee Y-J, Park SK, Kim H-C, Bae H, Kim HM, et al. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J Ethnopharmacol [Internet]. 2009;125(2):286–90. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0378874109004024
– reference: CicchittiLMartelliMCerritelliFChronic inflammatory disease and osteopathy: A systematic reviewPLoS One201510311810.1371/journal.pone.0121327
– reference: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Systematic Reviews of Intervention. 2nd edition. Chichester (UK); 2019. 694
– reference: Laksmitawati DR, Prasanti AP, Larasinta N, Syauta GA, Hilda R, Ramadaniati HU, et al. Anti-Inflammatory Potential of Gandarusa (Gendarussa vulgaris Nees) and Soursop (Annona muricata L) Extracts in LPS Stimulated-Macrophage Cell (RAW264.7). J Nat Remedies [Internet]. 2016;16(2):73. Available from: http://www.informaticsjournals.com/index.php/jnr/article/view/5367
– reference: Hunter RA, Storm WL, Coneski PN, Schoenfisch MH. Inaccuracies of Nitric Oxide Measurement Methods in Biological Media. Anal Chem [Internet]. 2013;85(3):1957–63. Available from: http://www.tandfonline.com/doi/full/https://doi.org/10.1080/10715760400017327
– reference: Kim M-J, Jeong S-M, Kang B-K, Kim K-B-W-R, Ahn D-H. Anti-Inflammatory Effects of Grasshopper Ketone from Sargassum fulvellum Ethanol Extract on Lipopolysaccharide-Induced Inflammatory Responses in RAW 264.7 Cells. J Microbiol Biotechnol [Internet]. 2019;29(5):820–6. Available from: http://www.jmb.or.kr/journal/view.html?doi=https://doi.org/10.4014/jmb.1901.01027
– reference: Beronius A, Molander L, Zilliacus J, Rudén C, Hanberg A. Testing and refining the Science in Risk Assessment and Policy (SciRAP) web-based platform for evaluating the reliability and relevance of in vivo toxicity studies. J Appl Toxicol [Internet]. 2018;38(12):1460–70. Available from: http://doi.wiley.com/https://doi.org/10.1002/jat.3648
– reference: Biluca FC, da Silva B, Caon T, Mohr ETB, Vieira GN, Gonzaga L V, et al. Investigation of phenolic compounds, antioxidant and anti-inflammatory activities in stingless bee honey (Meliponinae). Food Res Int [Internet]. 2020;129. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076113286&doi=10.1016%2Fj.foodres.2019.108756&partnerID=40&md5=532c50458a5140f6e7c1726ebc103f8f
– reference: Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS. Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages. Food Chem Toxicol [Internet]. 2013;59:199–206. Available from: https://linkinghub.elsevier.com/retrieve/pii/S027869151300375X
– reference: Fullerton JN, Gilroy DW. Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov [Internet]. 2016;15(8):551–67. Available from: http://www.nature.com/articles/nrd.2016.39
– reference: Lim D, Kim MK, Jang Y-P, Kim J. Sceptridium ternatum attenuates allergic contact dermatitis-like skin lesions by inhibiting T helper 2-type immune responses and inflammatory responses in a mouse model. J Dermatol Sci [Internet]. 2015;79(3):288–97. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0923181115300165
– reference: Liu T, Zhang L, Joo D, Sun S-C. NF-κB signaling in inflammation. Signal Transduct Target Ther [Internet]. 2017;2(1):17023. Available from: http://www.nature.com/articles/sigtrans201723
– reference: PageMJMcKenzieJEBossuytPMBoutronIHoffmannTCMulrowCDThe PRISMA statement: an updated guideline for reporting systematic reviewsBMJ.202010.1136/bmj.n7132933948
– reference: Meram C, Wu J. Anti-inflammatory effects of egg yolk livetins (α, β, and γ-livetin) fraction and its enzymatic hydrolysates in lipopolysaccharide-induced RAW 264.7 macrophages. Food Res Int [Internet]. 2017;100:449–59. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0963996917303563
– reference: Guo Z, Xu H-Y, Xu L, Wang S-S, Zhang X-M. In vivo and in vitro immunomodulatory and anti-inflammatory effects of total flavonoids of Astragalus. Africa J Tradit Complement Altern Med [Internet]. 2016;13(4):60–73. Available from: http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/3461/pdf
– reference: Da Silva LAL, Sandjo LP, Fratoni E, Kinoshita Moon YJ, Dalmarco EM, Biavatti MW. A single-step isolation by centrifugal partition chromatography of the potential anti-inflammatory glaucolide B from Lepidaploa chamissonis. J Chromatogr A [Internet]. 2019;1605:460362. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0021967319307460
– reference: Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev [Internet]. 2016;5(1):210. Available from: http://systematicreviewsjournal.biomedcentral.com/articles/https://doi.org/10.1186/s13643-016-0384-4
– reference: Hobbs S, Reynoso M, Geddis A V, Mitrophanov AY, Matheny RW. LPS-stimulated NF-kappa B p65 dynamic response marks the initiation of TNF expression and transition to IL-10 expression in RAW 264.7 macrophages. Physiol Rep. 2018;6(21).
– reference: SahaBKBurnsSLThe story of nitric oxide, sepsis and methylene blue: a comprehensive pathophysiologic reviewAm J Med Sci.202036043293710.1016/j.amjms.2020.06.00732631574
– reference: Ranaweera SS, Dissanayake CY, Natraj P, Lee YJ, Han C-H. Anti-inflammatory effect of sulforaphane on LPS-stimulated RAW 264.7 cells and ob/ob mice. J Vet Sci [Internet]. 2020;21(6). Available from: http://xlink.rsc.org/?DOI=C9FO01500K
– reference: Urbaniak GC, Plous S. Research Randomizer (Version 4.0). 2013.
– reference: Lind M, Hayes A, Caprnda M, Petrovic D, Rodrigo L, Kruzliak P, et al. Inducible nitric oxide synthase: Good or bad? Biomed Pharmacother [Internet]. 2017;93:370–5. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0753332217313562
– reference: Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med [Internet]. 2019;25(12):1822–32. Available from: http://www.nature.com/articles/s41591-019-0675-0
– reference: Altan A, Yuce H, Karataş O, Taşkan M, Gevrek F, Çolak S, et al. Free and liposome form of gallic acid improves calvarial bone wound healing in Wistar rats. Asian Pac J Trop Biomed [Internet]. 2020;10(4):156–63. Available from: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082821467&doi=10.4103%2F2221-1691.280297&partnerID=40&md5=276ab92945ffa8b6630ea0ccc384717d
– reference: He C, Lin H, Wang C, Zhang M, Lin Y, Huang F, et al. Exopolysaccharide from Paecilomyces lilacinus modulates macrophage activities through the TLR4/NF‑κB/MAPK pathway. Mol Med Rep [Internet]. 2019;20:4943–52. Available from: http://www.spandidos-publications.com/https://doi.org/10.3892/mmr.2019.10746
– year: 2020
  ident: 1584_CR16
  publication-title: BMJ.
  doi: 10.1136/bmj.n71
– ident: 1584_CR24
  doi: 10.1016/j.jep.2009.06.027
– ident: 1584_CR4
  doi: 10.1038/s41573-020-0082-8
– ident: 1584_CR55
  doi: 10.1038/sigtrans.2017.23
– ident: 1584_CR30
  doi: 10.1016/j.atherosclerosis.2019.02.017
– ident: 1584_CR46
  doi: 10.1080/10715760400017327
– ident: 1584_CR33
  doi: 10.1186/s12906-017-1635-1
– ident: 1584_CR53
  doi: 10.14814/phy2.13914
– ident: 1584_CR54
  doi: 10.1038/nrmicro2539
– ident: 1584_CR21
  doi: 10.1155/2019/6474168
– ident: 1584_CR9
  doi: 10.3390/ijms20184367
– ident: 1584_CR18
– ident: 1584_CR35
  doi: 10.4014/jmb.1901.01027
– ident: 1584_CR38
  doi: 10.1016/j.intimp.2017.05.021
– volume: 140
  start-page: 871
  issue: 6
  year: 2010
  ident: 1584_CR3
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.029
– ident: 1584_CR37
  doi: 10.3892/mmr.2017.6166
– ident: 1584_CR26
  doi: 10.1186/1471-2288-5-13
– volume: 10
  start-page: 1
  issue: 3
  year: 2015
  ident: 1584_CR6
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0121327
– ident: 1584_CR5
  doi: 10.3389/fimmu.2016.00160/abstract
– ident: 1584_CR49
  doi: 10.3389/fimmu.2020.01210/full
– volume: 360
  start-page: 329
  issue: 4
  year: 2020
  ident: 1584_CR15
  publication-title: Am J Med Sci.
  doi: 10.1016/j.amjms.2020.06.007
– ident: 1584_CR39
  doi: 10.1016/j.jdermsci.2015.06.012
– ident: 1584_CR45
  doi: 10.1016/j.foodchem.2016.01.114
– ident: 1584_CR27
  doi: 10.1002/jat.3648
– volume: 240
  start-page: 340
  issue: 170
  year: 1998
  ident: 1584_CR51
  publication-title: Blood Cells, Mol Dis
  doi: 10.1006/bcmd.1998.0201
– ident: 1584_CR56
  doi: 10.1039/C9FO01500K
– volume: 11
  start-page: 29
  issue: 11
  year: 2018
  ident: 1584_CR8
  publication-title: Asian J Pharm Clin Res
  doi: 10.22159/ajpcr.2018.v11i11.26873
– ident: 1584_CR20
  doi: 10.1016/j.foodchem.2017.12.015
– ident: 1584_CR25
– volume: 1
  start-page: 1
  issue: 6
  year: 2009
  ident: 1584_CR13
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a001651
– ident: 1584_CR11
  doi: 10.1371/journal.pone.0198943
– ident: 1584_CR23
  doi: 10.1016/j.fct.2013.05.061
– ident: 1584_CR12
– ident: 1584_CR43
  doi: 10.1016/j.chroma.2019.460362
– ident: 1584_CR1
  doi: 10.1038/nrd.2016.39
– ident: 1584_CR36
  doi: 10.1016/j.foodchem.2016.01.114
– ident: 1584_CR29
  doi: 10.1016/j.foodres.2017.07.032
– ident: 1584_CR7
  doi: 10.1038/s41591-019-0675-0
– ident: 1584_CR42
  doi: 10.18311/jnr/2016/5367
– ident: 1584_CR32
  doi: 10.3892/mmr.2019.10746
– ident: 1584_CR17
  doi: 10.1002/9781119536604
– ident: 1584_CR28
  doi: 10.1186/s13643-016-0384-4
– ident: 1584_CR52
  doi: 10.1159/000495922
– ident: 1584_CR10
  doi: 10.1146/annurev-pathol-012414-040418
– ident: 1584_CR22
– ident: 1584_CR34
  doi: 10.1139/cjpp-2014-0362
– ident: 1584_CR14
  doi: 10.1016/j.biopha.2017.06.036
– ident: 1584_CR47
  doi: 10.1080/10715760400017327
– ident: 1584_CR44
  doi: 10.31925/farmacia.2019.6.17
– ident: 1584_CR57
  doi: 10.4142/jvs.2020.21.e91
– ident: 1584_CR41
  doi: 10.1021/acs.jnatprod.8b00036
– ident: 1584_CR2
  doi: 10.1016/j.cell.2010.03.006
– ident: 1584_CR31
  doi: 10.21010/ajtcam.v13i4.10
– volume: 78
  start-page: 1233
  issue: 4
  year: 2021
  ident: 1584_CR50
  publication-title: Cell Mol Life Sci.
  doi: 10.1007/s00018-020-03656-y
– ident: 1584_CR19
– ident: 1584_CR40
  doi: 10.1016/j.jep.2014.11.032
– ident: 1584_CR48
  doi: 10.1016/0003-2697(82)90118-X
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Snippet Introduction Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells...
Several experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells has been...
IntroductionSeveral experimental models have been designed to promote the development of new anti-inflammatory drugs. The in vitro model using RAW 264.7 cells...
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SubjectTerms Allergology
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Biomarkers
Biomedical and Life Sciences
Biomedicine
Cell density
Dermatology
Drug development
IL-1β
Immunology
Inflammation
Inflammation Mediators
Interleukin 6
Interleukin-1beta - pharmacology
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Macrophages
Meta-analysis
Mice
Neurology
NF-kappa B
Nitric Oxide
Pharmacology/Toxicology
RAW 264.7 Cells
Review
Reviews
Rheumatology
Systematic review
Tumor Necrosis Factor-alpha - pharmacology
Tumor necrosis factor-TNF
Tumor necrosis factor-α
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Title Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis
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