Identification of miR-187 and miR-182 as Biomarkers of Early Diagnosis and Prognosis in Patients with Prostate Cancer Treated with Radical Prostatectomy

• Published in: The Journal of urology Vol. 192; no. 1; pp. 252 - 259
• Main Authors: Casanova-Salas, Irene, Rubio-Briones, José, Calatrava, Ana, Mancarella, Caterina, Masiá, Esther, Casanova, Juan, Fernández-Serra, Antonio, Rubio, Luis, Ramírez-Backhaus, Miguel, Armiñán, Ana, Domínguez-Escrig, José, Martínez, Francisco, García-Casado, Zaida, Scotlandi, Katia, Vicent, María J, López-Guerrero, José Antonio
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2014; Elsevier
• Subjects: Aged; Biological and medical sciences; biological markers; Biomarkers, Tumor - urine; diagnosis; Early Diagnosis; Gene Expression Regulation, Neoplastic; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; microRNAs; MicroRNAs - genetics; MicroRNAs - urine; Nephrology. Urinary tract diseases; Prognosis; Prostatectomy; prostatic neoplasms; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - surgery; Prostatic Neoplasms - urine; Retrospective Studies; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; microRNAs; BPFS; sRNA; small RNA; prostate cancer antigen 3; FDR; FFPE; formalin fixed, paraffin embedded; PFS; quantitative reverse transcriptase-PCR; false discovery rate; polymerase chain reaction; PSA; digital rectal examination; PCA3; progression-free survival; qRT-PCR; diagnosis; prostate specific antigen; prognosis; DRE; prostatic neoplasms; biological markers; biochemical PFS; PCR; Prostate tumor; Nephrology; RNA interference; Prognosis; Prostate disease; Biological marker; Early stage; Identification; Urology; Surgery; Diagnosis; Male genital diseases; Human; Urinary system disease; Micro RNA; Biological indicator; Malignant tumor; Gene silencing; Treatment; Prostatectomy; Prostate cancer; Cancer

Purpose miRNAs are noncoding RNAs that negatively regulate target mRNA gene expression. Aberrant miRNA expression is associated with prostate cancer pathogenesis. We identified miRNAs as potential biomarkers for prostate cancer diagnosis and prognosis. Materials and Methods Total RNA was obtained fr...