Membrane targeting peptides toward antileishmanial activity: Design, structural determination and mechanism of interaction

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 11; pp. 2861 - 2871
• Main Authors: Martins, Danubia Batista, Vieira, Maira Ramos, Fadel, Valmir, Santana, Viviane Aparecida Camargo, Guerra, Mirian Elisa Rodrigues, Lima, Marta Lopes, Tempone, Andre G., dos Santos Cabrera, Marcia Perez
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: amastigotes; Amino Acid Sequence - genetics; Aminophospholipids; Animals; Antimicrobial Cationic Peptides - chemistry; Antimicrobial Cationic Peptides - genetics; Antimicrobial Cationic Peptides - therapeutic use; Antimicrobial peptides; antiparasitic properties; bioassays; Biophysics; Cell Membrane - chemistry; Cell Membrane - drug effects; Circular Dichroism; circular dichroism spectroscopy; cytotoxicity; Decoralin; inhibitory concentration 50; leishmaniasis; Leishmaniasis - drug therapy; Leishmaniasis - parasitology; light scattering; lipid bilayers; macrophages; mammals; mechanism of action; molecular dynamics; Molecular Dynamics Simulation; Molecular dynamics simulations; new drugs; NMR; nuclear magnetic resonance spectroscopy; parasites; Peptide-lipid bilayer interactions; promastigotes; Protein Structure, Secondary; Structure-Activity Relationship; NMR; Peptide-lipid bilayer interactions; Molecular dynamics simulations; Aminophospholipids; Decoralin; Antimicrobial peptides

Leishmaniasis threatens poor areas population worldwide, requiring new drugs less prone to resistance development. Antimicrobial peptides with antileishmanial activity are considered among fulfilling alternatives, but not much is known about the mode of action of membrane-targeting peptides, conside...